<![CDATA[This study aimed to analyze the implementation of bioinformatics learning in senior high school from research articles. A systematic review was conducted in this study and showed the findings of relevant studies about the implementation of bioinformatics learning in senior high school. Three journals used for a systematic review: PLOS Computational Biology, Briefing Bioinformatics, and CBE-Life Science Education. A total of nine papers were included in the systematic review from 166 articles screened by criteria; bioinformatics learning or bioinformatics education at the senior high school level, published from 2010 to 2019. The result of this study is the trend of learning outcomes of bioinformatics learning at senior high school is to increase cognitive or knowledge in the Biology field, especially molecular biology (67%). The trend for the type of assessment in bioinformatics learning at senior high school is the observation to assess the learning outcome (44%). The trend of contents in bioinformatics learning used Biology, computer science, and information technologies (100%). The trend of bioinformatics tools in bioinformatics learning at senior high school is BLAST (44%). The trend of teaching strategy to implement bioinformatics learning at senior high school is inquiry and problem-based learning (each teaching strategy is 22%). The last is the trend of the period in implementing bioinformatics learning at senior high school is three periods in each topic (33%). For further study, the trend of implementation of bioinformatics learning can be integrated to design the new framework for implementing bioinformatics learning at senior high school. These findings recommended that science teachers or science educators promote bioinformatics learning at senior high schools.]]>
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