International Journal of Applied Biology
Vol. 6 No. 2 (2022): International Journal of Applied Biology

In Silico Testing on the Activity of Quercetin in the Skin of Onion Allium Cepa L as A Natural Antihypertensive Compound

Andi Ariyandy (a:1:{s:5:"en_US"
s:63:"Departemen Fisiologi Fakultas Kedokteran Universitas Hasanuddin"
})
Nindrahayu (Hasanuddin University Hospital)
Ami Febriza (University of Muhammadiyah Makassar)
Andi Irwan Muluk (Hasanuddin University)
Sulfahri (Hasanuddin University)

Article Info

Publish Date
29 Dec 2022

Abstract

This study aims to determine the bioactivity of the compound quercetin in the peel of Allium cepa L as a natural antihypertensive compound. The chemical structure of the quercetin compound found in Allium cepa L peel was taken from the literature. The target protein used was Angiotensin-Converting Enzyme (ACE), while the control compound was lisinopril. Water molecules were removed using PyMol v2.5.2 Software. Docking between the target protein and the compound was carried out using PyRx-Python Prescription 0.8 Software. The results showed that the quercetin compound had more significant potential as an antihypertensive compared to lisinopril as a control compound. The affinity ratio of the Angiotensin-converting enzyme with quercetin is -8.1, while the affinity value of the Angiotensin-converting enzyme with lisinopril is -7.1.

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Journal Info
International Journal of Applied Biology
Website

Abbrev

ijoab

Publisher

Universitas Hasanuddin

Subject

Agriculture, Biological Sciences & Forestry Automotive Engineering Energy Environmental Science

Description

International Journal of Applied Biology is an international, peer reviewed journal, publishing high-quality research. International Journal of Applied Biology only publishes manuscripts in English. Please see the journal's Focus & Scope for information about its Scope and peer-review policy. ...