MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Vol 10, No 1 (2023): February

Effectiveness of Bitter melon (Momordica charantia L) Extract on Growth of Trichopyton rubrum: In Vitro Study

Vika Pangesty (Universitas Muhammadiyah Semarang, Semarang, Central Java, Indonesia)
Ika Dyah Kurniati (Universitas Muhammadiyah Semarang, Semarang, Central Java, Indonesia)
Kanti Ratnaningrum (Universitas Muhammadiyah Semarang, Semarang, Central Java, Indonesia)



Article Info

Publish Date
01 Feb 2023

Abstract

Trichophyton rubrum is type of fungus that most often causes superficial fungal infections. Development of herbal ingredients as antifungal therapy is carried out to find alternative therapies for fungal infections. Bitter melon contains various compounds that have potential to be used as antifungals, including flavonoids and saponins. The aim of this study was to determine the effect of bitter melon extract (Momordica charantia L) on the growth of Trichopyton rubrum. This study used bitter melon extract at concentrations of 5%, 25%, 50%, 75% and 100%. Ketoconazole concentrations of 2% was used as a positive control. Pure cultures of Trichopyton rubrum were diluted using physiological NaCl. Fungal growth was observed microscopically and macroscopically. Results showed that Trichopyton rubrum grew at a concentration of 5% while at concentrations of 25%, 50%, 75% and 100% there was no Trichopyton rubrum growth. Bitter melon extract at a concentration of 25% had similar effect as ketoconazole 2%. Conclusion Bitter melon extract at concentrations of 25%, 50%, 75% and 100% had a similar effect to 2% ketoconazole in inhibiting the growth of Tricophyton rubrum.

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Journal Info

Abbrev

APKKM

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this ...