<![CDATA[Currently, the effort to invent ideal natural male contraceptives still faces many obstacles, especially due to the fact that ideal contraceptives should meet certain requirements such as: be able to cause total azoospermia; easily used; cause no untoward or toxic effects; not disturbing libido or sexual behavior; and be reversible. As male contraceptives are very limited in types, efforts to develop ideal male contraceptive drugs is crucial; particularly the effort to find alternative effective substances derived from natural resources. The purpose of this study is to investigate whether of young papaya seeds extract has a to inhibit the testosterone. The study used 30 male mice strain Balb-C which were allocated by simple random sampling into two groups: Control Group (P0) consisted of 17 male mice and Treatment Group 1 (P1) consisted of 17 male mice. After 36 days of treatment, control group and treatment group were taken for their blood. The blood was taken for testosterone hormone test using Radioimmunoassay (RIA) technique and the scrotum was taken for obtaining the Leydig cells. The result of t-test analysis showed that the level of testosterone in control group was 104,27 ± 25,79 ng/dl and Leydig cells 129,41±30,92, in treatment group 91,76 ± 30,45 ng/dl and Leydig cells 122,94±20,85. The difference between control group and treatment group was the decrease of testosterone and Leydig cells. Young papaya seeds extract reduces testosterone and Leydig cells insignificantly.Keywords: Papaya seeds extract, Testosterone hormone, Leydig cel, Male Mice balb/C]]>
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