Acta Chimica Asiana
Vol. 6 No. 1 (2023)

C-prenylation of 1,3 dihydroxyxanthone: synthesis, characterization and antibacterial activity

Emmy Yuanita (UNIVERSITAS MATARAM)
Baiq Khaeratul Jannah (Department of Chemistry, Faculty of Science, University of Mataram)
Maria Ulfa (Department of Chemistry, Faculty of Science, University of Mataram)
Sudirman (Department of Chemistry, Faculty of Science, University of Mataram)
Baiq Nila Sari Ningsih (Department of Chemistry, Faculty of Science, University of Mataram)
Ni Komang Tri Dharmayani (Department of Chemistry, Faculty of Science, University of Mataram)

Article Info

Publish Date
25 Feb 2023

Abstract

Prenylated 1,3-dihydroxyxanthone has been successfully synthesized using Prenyl bromide and KOH. Characterization of the synthesized compound using Infra Red (IR) and Nuclear Magnetic Resonance (1H-NMR) showed that monosubstituted c-prenylation was occurred at carbon number 2 to form 1,3-dihydroxy-2-prenylxanthone. The synthesis result was a yellow-brown paste with a yield of 43.09%. This prenylated 1,3-dihydroxyxanthone had moderate antibacterial activity against Escherichia coli with an inhibition zone > 5 mm at a concentration of 15%.

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Journal Info
Acta Chimica Asiana
Website

Abbrev

ACA

Publisher

Universitas Mataram

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

Description

Acta Chimica Asiana (online ISSN 2550-0503, print ISSN 2550-049x) is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles and short communication in all areas of Chemistry, including Chemical Education and Chemical Engineering. The ...