Pharmaceutical Journal of Indonesia
Vol. 8 No. 2 (2023): PJI Vol 8.2

ANTIVIRAL ACTIVITY OF FABACEAE AND ASTERACEAE FLAVONOID COMPOUNDS AGAINST SARS-CoV-2 ON SPIKE PROTEIN, MAIN PROTEASE (Mpro) AND RNA DEPENDENT RNA POLYMERASE (RdRp) RECEPTORS WITH IN SILICO METHOD: ANTIVIRAL ACTIVITY OF FABACEAE AND ASTERACEAE FLAVONOID COMPOUNDS AGAINST SARS-CoV-2 ON SPIKE PROTEIN, MAIN PROTEASE (Mpro) AND RNA DEPENDENT RNA POLYMERASE (RdRp) RECEPTORS WITH IN SILICO METHOD

Tresia Lekal (Surabaya University)
Dini Kesuma (Surabaya University)
Azminah Azminah (Unknown)

Article Info

Publish Date
29 Jun 2023

Abstract

This study was conducted to test the antiviral activity of flavonoid compounds of Fabaceae tribe (Clitoria ternatea, Caesalpinia sappan, Leucaena leucocephala, Indigofera tinctoria) and Asteraceae tribe (Eclipta prostrata, Artemisia vulgaris, Blumea balsamifera, Chromolaena odorata) against SARS-CoV-2 on spike protein, Mpro and RdRp receptors by molecular docking method in silico. The results of molecular docking with AutoDock Vina showed that the flavonoid compounds apigenin and juglanin (Leucaena leucocephala), semiglabrin and glabratephrin (Indigofera tinctoria), apigetrin (Eclipta prostrata), acacetin (Chromolaena odorata) had binding energies close to, equivalent and better than the original ligand and Comparator of each receptor.

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Journal Info
Pharmaceutical Journal of Indonesia
Website

Abbrev

pji

Publisher

Universitas Brawijaya

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Pharmaceutical Journal of Indonesia (PJI) is an online journal which is published twice a year by Department of Pharmacy, Faculty of Medicine, Brawijaya University. The articles published in PJI cover the themes of Clinical and Community Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Technology, ...