<![CDATA[Data theft from year to year has increased in the era of big data and society 5.0. One area that requires data security is patient medical data. Medical image data security must be done to protect medical data security from data theft by third parties so that they cannot access the data. The development of Diabetic Retinopathy (DR) is also increasing every year. Determining the severity of DR is done by detecting the Foveal Avascular Zone (FAZ). Encryption is the process of changing a plain image into a cipher image. In this study, we compared the results of image quality and encryption time between the Vigenere Cipher method and a combination of pixel scrambling. The average encryption time of the tested FAZ images is 3.20 seconds. This result proves that the pixel combination method has a faster encryption time than the Vigenere Cipher. Vigenere Cipher encryption time is 4.96 seconds. The existence of the FAZ area with the pixel combination randomization method of the encryption process is also invisible, so third parties will not know about its existence.]]>
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