Vol. 1 No. 2 (2023): Bioactivities

The Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials

Yehezkiel Steven Kurniawan (Department of Chemistry, Universitas Gadjah Mada, Yogyakarta-55281 (Indonesia))
Tantiana Indriani (Department of Chemistry, Universitas Ma Chung, Malang-65151 (Indonesia))
Hanif Amrulloh (Department of Islamic Primary School Teacher Education, Universitas Ma’arif Lampung, Metro-34111 (Indonesia))
Langit Cahya Adi (Laboratoire National des Champs Magnétiques Intenses (LNCMI) – CNRS, 25 Avenue des Martyrs, Grenoble-38042 (France))
Arif Cahyo Imawan (Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei-10607 (Taiwan))
Krisfian Tata Aneka Priyangga (Pre-service Teacher Professional Education Program, Field of Chemistry, Universitas Negeri Yogyakarta, Yogyakarta-55281 (Indonesia))
Ervan Yudha (Department of Chemistry, Universitas Gadjah Mada, Yogyakarta-55281 (Indonesia))

Article Info

Publish Date
12 Sep 2023


Nature serves as an excellent inspiration for researchers in the fields of chemistry and medicine. Terrestrial or marine organisms produce billions of natural products with unique chemical and physical properties. Some of them have been used in traditional therapy for specific diseases since ancient times. Although their exact chemical structures have yet to be elucidated clearly in that time, investigations in medicinal chemistry have been well documented. Furthermore, utilizing natural products in drug design and development offers advantages such as high biocompatibility, low toxicity, fewer side effects, wide bioactivities, and large structure diversity. Nowadays, rational drug research using computer-aided drug design is well established to cut the long way of drug discovery and overcome the resistance cases and the increment in the number of active patients. This review will highlight some natural products to comprehensively understand their journey from unknown natural products, isolation, purification, characterization, in silico evaluation, bioactivity screening assay, drug modifications, in vitro investigation, in vivo examination, and clinical trial.

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Journal Info





Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology


Bioactivities is a double-blind peer-reviewed journal for research activity on bioactivities of materials or compounds. This journal aims to provide a means for sustained discussion of relevant issues that fall within the focus and scopes of the journal which can be examined empirically in the ...