ABSTRACT Stroke is leading cause of disability in Indonesia. Approximately 80% of stroke patients experience disabilities in their upper extremities. In recent years, immersive Virtual Reality (VR) technology has been used as a promising modality for neurorestoration. VR-based neurorestoration can induce neuroplasticity, Mirror-Neuron System (MNS) and Brain Reward System, leading to contrasted improvements in the upper extremity after stroke. This review prompts systematic understanding of the mechanisms of VR-based stroke neurorestoration and summarizes the emerging evidence for ongoing innovation of VR systems and application in stroke neurorestoration. Keywords: Virtual Reality, Neurorestoration, Stroke, Upper Extremity
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