Jurnal Sains dan Kesehatan
Vol. 6 No. 2 (2024): J. Sains Kes.

Kajian Interaksi Obat Antihipertensi pada Pasien Gagal Jantung Kongestif di Ruang ICCU RSUD dr. Soedarso Pontianak: Antihypertensive Drug Interaction Study in Congestive Heart Failure Patients in the ICCU Room of RSUD dr. Soedarso Pontianak

Elisabeth indah Mulatsih (Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak, Kalimantan Barat, Indonesia)
Shoma Rizkifani (Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak, Kalimantan Barat, Indonesia)
Siti Nani Nurbaeti (Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak, Kalimantan Barat, Indonesia)



Article Info

Publish Date
30 Apr 2024

Abstract

Treatment therapy that uses various types of drugs is known as polypharmacy. Patients with congestive heart failure are at risk of experiencing interactions between drugs that can have beneficial or detrimental effects on patients. This study aims to describe the number of interaction events in patients with congestive heart failure who are treated in the ICCU room at RSUD dr. Soedarso for the period from January to December 2021. Retrospective data collection and purposive sampling technique. 130 data met the inclusion criteria. Data were analyzed using Microsoft Excel, chi square test, Stockley's Drug Interaction E-book edition 8, the Drug Interaction Checker application, accessed through Medscape.com and drugs.com. The results showed that the potential for drug interactions of 130 patients on the use of antihypertensive drugs had 634 interactions, 458 pharmacodynamic interactions (72.23%), 35 pharmacokinetic interactions (5.52%), and 141 unknown interactions. (22.23%), The chi square test showed a p-value <0.001. This study concludes the percentage of drug interactions that occur in GJK patients in the ICCU room at RSUD dr. Soedarso in pharmacodynamics.   Keywords:          Antihypertensive, Pharmacodynamics, Congestive Heart Failure, Interaction   Abstrak Terapi pengobatan yang menggunakan berbagai jenis obat dikenal dengan nama polifarmasi. Penderita gagal jantung kongestif memiliki risiko mengalami interaksi antar obat yang dapat memberikan efek menguntungkan atau merugikan bagi pasien. Penelitian ini bertujuan untuk menggambarkan jumlah kejadian interaksi pada pasien gagal jantung kongestif yang dirawat di ruang ICCU RSUD dr. Soedarso periode Januari hingga Desember 2021. Pengambilan data secara retrospektif dan teknik purposive sampling. Data yang memenuhi kriteria inklusi sebanyak 130. Data melalui  analisis dengan menggunakan Microsoft Excel, uji chi squareE-book Stockley’s Drug Interaction edisi 8, aplikasi Drug Interaction Checker yang dapat diakses melalui Medscape.com dan drugs.com. Hasil penelitian menunjukkan potensi interaksi obat dari 130 pasien pada penggunaan obat  antihipertensi memiliki total kejadian sebanyak 634 interaksi, dan interaksi farmakodinamik sebanyak 458 kejadian (72,23%), farmakokinetik sebanyak 35 kejadian (5,52%), dan tidak diketahui sebanyak 141 kejadian (22,23%), uji chi square memberikan hasil p-value <0,001. Kesimpulan dari penelitian ini adalah persentase interaksi obat yang banyak terjadi pada pasien GJK di ruang ICCU RSUD dr. Soedarso secara farmakodinamik.   Kata Kunci:         Antihipertensi, Farmakodinamik, Gagal Jantung Kongestif, Interaksi

Copyrights © 2024






Journal Info

Abbrev

jsk

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

Description

Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is ...