INDONESIAN JOURNAL OF PHARMACY
Vol 24 No 4, 2013

STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM.

Bokshi, Bishwajit ( Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 Bangladesh.)
Zilani, Md.Nazmul Hasan ( Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 Bangladesh.)
Malakar, Aparajita ( Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 Bangladesh.)
Roy, Debendra Nath ( Pharmacy, Jessore Science and Technology University, Independence Road), 7408-Bangladesh)
Shilpi, Jamil Ahmad ( Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 Bangladesh.)
Sadhu, Samir Kumar ( Pharmacy Discipline, Khulna University, Khulna, Khulna-9208 Bangladesh.)



Article Info

Publish Date
01 Oct 2013

Abstract

The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activity. Again between the two fractions of crude ethanol extract ethyl acetate fraction of S.caseolaris stem have most significant antidiarrhoeal activity.Key words: analgesic, antidiarrhoeal, S.caseolaris, diclofenac sodium, loperamide.

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Journal Info

Abbrev

3

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...