INDONESIAN JOURNAL OF PHARMACY
Vol 26 No 2, 2015

SYNTHESIS OF TETRAHYDROHEXAGAMAVUNON-5 AND TETRAHYDROHEXAGAMAVUNON-7

Ritmaleni Ritmaleni (1Pharmaceutical Chemistry Section, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia 2Curcumin Research Center (CRC), Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia)
Ian Praditya (1Pharmaceutical Chemistry Section, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia)
Haryono Wibowo (1Pharmaceutical Chemistry Section, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia)
Sardjiman Sardjiman (1Pharmaceutical Chemistry Section, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia 2Curcumin Research Center (CRC), Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia)



Article Info

Publish Date
05 Apr 2015

Abstract

Synthesis of Tetrahydrohexagamavunon-5 (THHGV-5) and Tetrahydrohexagamavunone-7 (THHGV-7) were prepared by catalytic hydrogenation reaction on Hexagamvunon-5 (HGV-5) and Hexagamavunone-7 (HGV-7) by using gas H2 as source of hydrogen gas, Pd/C 10 % as metal catalyst and methanol as solvent at room temperature. The products were characterized by IR Spectroscopy, Gas Chromatography-Mass Spectroscopy (GCMS), 1D-NMR (1H-NMR and 13C-NMR) and 2D-NMR (1H-13C HMQC) Spectroscopy to determine the product structure molecules. According to the data of IR, GC-MS, 1H-NMR, 13C-NMR and 1H-13C HMQC spectra, the products are THHGV-5 and THHGV-7 as white crystalline powders. Key words:Tetrahydrohexagamavunon-5, Tetrahydrohexagamavunone-7, Hexagamvunon-5, Hexagamavunone-7

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Journal Info

Abbrev

3

Publisher

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...