Heart Science Journal
Vol 5, No 1 (2024): Inflammation and Cardiovascular Disease

Correlation Between Platelet Index, Neutrophil-Lymphocyte Ratio, and Mean Platelet-Volume Lymphocyte Ration with Lesion in Chronic Coronary Syndrome Based on SYNTAX Score

Zainal Fathurohim (Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Cholid Tri Tjahjono (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Maimun Zulhaidah Arthamin (Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)
Novi Kurnianingsih (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia)



Article Info

Publish Date
31 Jan 2024

Abstract

AbstractBackground: Platelet aggregation and inflammation have been associated with atherosclerosis, and inflammatory parameters such as mean platelet volume (MPV), platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR), and mean platelet-lymphocyte volume ratio (MPLVR) are often used. However, the relationship between these inflammatory parameters and the SYNTAX Score in CAD remains uncertain.Objective : The purpose of this study was to investigate the relationship between angiographic SYNTAX score, NLR, and platelet parameters (MPV, PLR, MPLVR).Material and Methods : We conducted a study involving patients undergoing elective coronary angiography from January 2023 to June 2023 at Dr. Saiful Anwar General Hospital, who were 18 years of age or older and had CAD. All participants willingly agreed to be part of the study. We collected complete routine blood counts and performed blood biochemistry assessments 24 hours before the coronary angiography procedure. Pearson's correlation was used to examine the relationship between the variables.Result: A total of 366 individuals meeting the study's inclusion criteria were included. MPV, PLR, MPLVR, NLR, and PDW showed weak to negligible correlations with the SYNTAX Score, displaying correlation coefficients of 0.260, 0.190, 0.320, 0.470, and 0.290, respectively, all with p-values <0.001.Conclusion: This study in individuals with coronary artery disease revealed a limited to negligible correlation between the SYNTAX Score and inflammatory parameters including MPV, PLR, MPLVR, NLR, and PDW. 

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Journal Info

Abbrev

heartscience

Publisher

Subject

Health Professions Immunology & microbiology Medicine & Pharmacology

Description

HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The ...