Jurnal Kartika Kimia
Vol 6 No 2 (2023): Jurnal Kartika Kimia

Synthesis and Biological Evaluation of N'-Arylidene-4-Hydroxybenzohydrazides against α-Glucosidase Enzyme

Danova, Ade (Unknown)
Hermawati, Elvira (Unknown)
Chavasiri, Warinthorn (Unknown)

Article Info

Publish Date
22 Nov 2023

Abstract

Hydrazides have been reported to have a broad spectrum of bioactivities, such as anticancer, antifungal, antibacterial, and antidiabetic. Thus, our work aimed to synthesize N'-arylidene-4-hydroxybenzohydrazides and investigate their α-glucosidase inhibition. Three compounds (AD-H1-3) were synthesized with a yield of product from 33 to 65% and then characterized using 1H-and 13C-NMR spectroscopy. The in vitro α-glucosidase inhibition demonstrated that AD-H2 possessing two hydroxy groups on arylidene moiety showed the best inhibitory activity against α-glucosidase enzyme with an IC50 value of 14.4 µM compared with acarbose as a positive control with IC50 value of 93.6 µM. Thus, AD-H2 could be a candidate as a lead compound for antidiabetics.

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Journal Info
Jurnal Kartika Kimia
Website

Abbrev

jkk

Publisher

Universitas Jenderal Achmad Yani

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education

Description

Jurnal Kartika Kimia is National Journal that publish all research article/ review/ short communication related to progres of chemistry researchs. Scope of this journal are: 1) Analytical Chemistry ; 2) Inorganic Chemistry ; 3) Physical Chemistry ; 4) Organic Chemistry ; 5) Biochemistry also ...