The Indonesian Biomedical Journal
Vol 6, No 2 (2014)

Dynamic Pattern of Interleukin-1beta and -10 in Cerebrospinal Fluid following Aneurysmal Subarachnoid Hemorrhage

Yesaya Yunus (Department of Neurosurgery, Faculty of Medicine, Universitas Pelita Harapan Lippo Village, Jl. Siloam No.6, Tangerang)
Julius July (Department of Neurosurgery, Faculty of Medicine, Universitas Pelita Harapan Lippo Village, Jl. Siloam No.6, Tangerang)
Andi Asadul Islam (Department of Neurosurgery, Faculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.11, Makassar)
Eka Julianta Wahjoepramono (Department of Neurosurgery, Faculty of Medicine, Universitas Pelita Harapan Lippo Village, Jl. Siloam No.6, Tangerang)
Irawan Yusuf (Department of Physiology, Faculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, Makassar)



Article Info

Publish Date
01 Aug 2014

Abstract

BACKGROUND: Inflammation following aneurysmal subarachnoid hemorrhage (SAH) is associated with patient outcome. This study aimed to analyze the dynamics pattern of the pro-inflammatory interleukin (IL)-1β and anti-inflammatory cytokine IL-10 in the cerebrospinal fluid (CSF) following aneurysmal SAH.METHODS: This is a prospective observational study. The CSF was collected prior to surgery, and on the 2nd, 4th and 6th days after surgery. The CSF was then analyzed for IL-1β and -10 using enzyme-linked immunosorbent assay. Delayed Ischemic Neurological Deficits (DIND) was determined based on new neurological deficits within the first week after surgery. Data was analysed with T test or Wilcoxon Rank-Sum test to evaluate the pattern of biomarkers between DIND and non-DIND groups.RESULTS: There were 33 patients enrolled in this study, 16 patients (48.48%) who experienced DIND and 17 patients (51.52%) were non-DIND. There were significant increase dynamic levels of IL-10 and -1β in DIND patients (p<0.05).CONCLUSION: Significant increase levels of IL-10 and -1β in CSF after aneurysmal SAH are associated with DIND.KEYWORDS: IL-1β, IL-10, DIND

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