JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia

Skrining Aktivitas Antimalaria Beberapa Tanaman Indonesia Hasil Eksplorasi Dari Hutan Raya Cangar, Batu-Malang, Jawa Timur

Achmad Fuad Hafid (1. Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya 2. Center for Natural Product Medicine Research and Development, Lembaga Penyakit Tropis, Universitas Airlangga)
Nike Puliansari (Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya)
Nur Suci Lestari (Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya)
Lidya Tumewu (Center for Natural Product Medicine Research and Development, Lembaga Penyakit Tropis, Universitas Airlangga)
Abdul Rahman (1. Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya 2. Center for Natural Product Medicine Research and Development, Lembaga Penyakit Tropis, Universitas Airlangga)
Aty Widyawaruyanti (1. Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya 2. Center for Natural Product Medicine Research and Development, Lembaga Penyakit Tropis, Universitas Airlangga)



Article Info

Publish Date
04 Aug 2017

Abstract

Background: Malaria is the most important parasitic disease. Malaria control which depends on specific chemotherapy now complicated by resistance of Plasmodium falciparum to most commonly available antimalarial drug. Such situation has heralded the need for alternative antimalarial therapy. Objective: This research aim was to find new antimalarial candidates from some Indonesia plants collected from Cangar National Forest, Batu-Malang, East Java. Methods: Eleven samples of leaves and stem extracts were screened against Plasmodium falciparum 3D7 culture which maintained in RPMI-1640 Medium. Samples tested in concentration of 0.01, 0.1, 1, 10 and 100 µg/ml. Probit analysis was used to determine IC50. Results: In vitro antimalarial activity revealed that only three crude extracts samples from Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract had good antimalarial activity with IC50 value of 0.33, 0.20 and 0.55 µg/ml, respectively. Conclusions: Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract might be a good candidate for antimalarial natural product resources.

Copyrights © 2016






Journal Info

Abbrev

JFIKI

Publisher

Subject

Chemistry Education Health Professions Medicine & Pharmacology Other

Description

Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada ...