Majalah Obat Tradisional
Vol 19, No 1 (2014)

EVALUASI EFEK ANTI-DIABETES MELITUS EKSTRAK TERPURIFIKASI Andrographis paniculata (Burm. f.) Nees DAN ANDROGRAFOLID DENGAN PARAMETER INDEKS HOMA-IR

Ignatius Ryan Adriawan (Faculty of Medicine, Universitas Gadjah Mada)
Mohamad Andrie (Faculty of Medicine, Tanjungpura University)
Rina Susilowati (Faculty of Medicine, Universitas Gadjah Mada)
Suwidjiyo Pramono (Faculty of Pharmacy, Universitas Gadjah Mada)
Agung Endro Nugroho (Faculty of Pharmacy, Universitas Gadjah Mada)

Article Info

Publish Date
24 Nov 2015

Abstract

Diabetes mellitus type 2 was induced by high fat diet and fructose. The insulin resistance and hyperinsulinemia compensatory can be measured by index homeostatic model assessment – insulin resistance (HOMA-IR). Andrographis paniculata (Burm. f.) Nees is a traditional plant can be used to treat diabetes mellitus and the main active compound of this plant is Andrographolide. The objective of this study is to evaluate the effect of purified extract of Andrographis paniculata (Burm. f.) Nees and andrographolide on HOMA-IR index of High fat diet and fructose induced Wistar Rats. This study is quasi-experimental and data analysis was using Kruskal-Wallis test. The result showed that purified extract of Andrographis paniculata and andrographolide decreased HOMA-IR index. Purified extract of Andrographis paniculata 1303,8 mg/kg decreased HOMA-IR index by 82,05 %.

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Journal Info
Majalah Obat Tradisional
Website

Abbrev

TradMedJ

Publisher

Universitas Gadjah Mada

Subject

Health Professions Medicine & Pharmacology Public Health

Description

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, ...