Journal of Tropical Pharmacy and Chemistry
Vol. 4 No. 1 (2017): Journal of Tropical Pharmacy and Chemistry

Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico

Yurika Sastyarina (Fakultas Farmasi, Universitas Mulawarman Samarinda, Indonesia)
Zuhrotun Nafisah (Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Padjadjaran, Indonesia)
Muhammad Yusuf (Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Padjadjaran, Indonesia)
Martalena Ramli (Pusat Teknologi Radioterapi Radiofarmaka, BATAN, Puspitek Serpong, Indonesia)
Abdul Mutalib (Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Padjadjaran, Indonesia)
Ukun Soedjanaatmadja (Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Padjadjaran, Indonesia)

Article Info

Publish Date
30 Jun 2017

Abstract

Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Å and at the terminal region between residues 100 and 122 is 58.045 Å

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Journal Info
Journal of Tropical Pharmacy and Chemistry
Website

Abbrev

jtpc

Publisher

Universitas Mulawarman

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health

Description

Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: ...