Journal of Tropical Pharmacy and Chemistry
Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry

Aktivitas Antioksidan Senyawa Kumarin Ter-O-Geranilasi dari Akar Limonia acidissima L.

Tjitjik Srie Tjahjandarie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia)
Ratih Dewi Saputri (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia)
Mulyadi Tanjung (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia)

Article Info

Publish Date
31 Dec 2017

Abstract

Five O-geranylated coumarins namely as auraptene (1), 7-((2’E,6’E)-5’-hydroxy-3’,7’-dimethylocta-2’,6’-dienyloxy)coumarin (2), 7-(2’E,5’E)-7’-hydroxy-3’,7’-dimethylocta-2’,5’-dienyloxy) coumarin (3), 6-methoxy-7-oxygeranylcoumarin (4), and 8-oxygeranylpsoralen (5) were isolated from the roots of Limonia accidissima L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–5 were evaluated for their radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 462; 13; 260; 210 and 234 µg/ml, respectively. Keywords: Limonia accidissima L., O-geranylated coumarins, antioxidant activity, DPPH

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Journal Info
Journal of Tropical Pharmacy and Chemistry
Website

Abbrev

jtpc

Publisher

Universitas Mulawarman

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health

Description

Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: ...