Journal of Tropical Pharmacy and Chemistry
Vol. 4 No. 4 (2018): Journal of Tropical Pharmacy and Chemistry

Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline

Nurul Khotimah (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Agung Rahmadani (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Dewi Rahmawati (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Mirhansyah Ardana (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)

Article Info

Publish Date
31 Dec 2018

Abstract

Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity.

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Journal Info
Journal of Tropical Pharmacy and Chemistry
Website

Abbrev

jtpc

Publisher

Universitas Mulawarman

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health

Description

Journal of Tropical Pharmacy and Chemistry is a Biannual, international, open access (Indexed in DOAJ, Crossref, SINTA, PKP Index, BASE, Moraref, Google Scholar), journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry (ISSN-p: ...