eJurnal Kedokteran Indonesia
Vol 1, No 2 (2013): Agustus

Effects of High-sugar and High-fat Diet on Fat Deposition and Blood Vessel Wall on Sprague Dawley Rats Liver

Vera Citra Setiawan Hoei (Unknown)



Article Info

Publish Date
07 Nov 2013

Abstract

People nowadays tend to consume more fast food and sweetened beverages. These foods usually contain high amount sugar and fat that have effects on the body including liver.This study was conducted to explore the effects of extensive intake of sugar and fat on blood glucose and cholesterol level as well as changes in liver. Research was conducted with experimental method using 20 Sprague Dawley rats which were divided into 4 groups; 2 controls and 2 treatments. Rats were given 5 ml sugar or lard alternatively every 2 consecutive days for 1-month and 2-month respectively. Data was retrieved include blood glucose and cholesterol level, fatty liver percentage and blood vessel thickening after intervention through HE staining. The results showed that both 1-month and 2-month intervention group has significant increase in blood glucose and cholesterol level. However, the enhancement of fatty liver percentage and number of thickened blood vessels (p<0.05) were only foundsignificant (p<0.05) in 1-month intervention group. We concluded that high intake of sugar and fat within 1-monthintervention have significant effects on the rat body including liver. Nevertheless, it was not found significant in 2-months intervention. Further studies are still needed to analyze this incongruent result.Key words: high-sugar diet, high-fat diet, fatty liver, atherosclerosis

Copyrights © 2013






Journal Info

Abbrev

eJKI

Publisher

Subject

Medicine & Pharmacology

Description

Elektronik Journal Kedokteran Indonesia (eJKI) is a peer-reviewed and open access journal that prioritize the publication manuscript of students (medical education program, magister/specialist, doctoral). This journal publishes editorial, research article, reviews, evidence-based case report, and ...