<![CDATA[Metamizol intravena dan parasetamol intravena dapat menurunkan suhu tubuh pasien cedera otak sedang sampai berat dengan menghambat produksi PGE2 sebagai mediator demam. Penelitian ini bertujuan untuk membandingkan pemberian metamizol intravena dengan parasetamol intravena terhadap kadar PGE2 plasma dalam menurunkan suhu tubuh pasien cedera otak sedang sampai berat dengan demam. Sampel penelitian adalah 44 pasien cedera otak sedang sampai berat dengan demam, dibagi dalam 2 kelompok. Kelompok M (n=22) diberikan metamizol IV 15 mg/kgBB, sedangkan kelompok P (n=22) diberikan parasetamol 15 mg/kgBB. Analisis statistik dilakukan dengan Uji Mann U-Whitney dan Uji Pearson, dengan p<0,05 bermakna secara signifikan. Hasil penelitian menunjukkan bahwa terdapat penurunan suhu dan kadar PGE2 plasma yang bermakna pada kedua kelompok (p<0,05). Hasil Uji korelasi Person memperlihatkan bahwa semakin tinggi suhu semakin tinggi pula kadar PGE2 plasma. Metamizol intravena sama efektifnya dengan parasetamol dalam menurunkan suhu tubuh dan kadar PGE2 plasma pada pasien cedera otak sedang sampai berat dengan demam.
Kata kunci: Cedera otak, kadar PGE2, metamizol, parasetamol, suhu
Intravenous metamizol and paracetamol can lower body temperature on moderate to severe traumatic brain injury patients with fever by inhibiting the production of PGE2 as a mediator of fever. This study aims to compare the effect between intravenous metamizol and paracetamol on the PGE2 plasma level in lowering body temperature on moderate to severe traumatic brain injury patients with fever. The study samples consist of 44 severe to moderate traumatic brain injury patients with fever divided in 2 groups: M group (n=22) was given metamizol IV of 15 mg/BW body weight and P group (n=22) was given paracetamol of 15 mg/BW body weight. Statistically analyzed was using Mann U-Whitney Test and Pearson chi-square test with p<0,05 of statistical significance. Temperature and PGE2 plasma levels significantly decrease in both groups (p<0,05). The result of the Pearson correlation test shows that the higher the temperature the higher the PGE2 plasma level. Intravenous metamizol and paracetamol have proven effective to lower body temperature and PGE2 plasma levels of moderate to severe traumatic brain injury patients with fever.
Key words: Metamizol, paracetamol, PGE2 level, temperature, traumatic brain injury
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