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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
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Articles 14 Documents
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Search results for , issue "Vol. 42 No. 3 (2023)" : 14 Documents clear
Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats David Tjahyadi; Edy Parwanto; Sisca Sisca; Endrico Xavierees; Hosea Jaya Edy; Reza Aditya Digambiro; Ashaolu Victoria Oladimeji; Joey Joshua Vidova Tjahyadi; Laurentia Gabrielle
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

Abstract

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Role of sex steroid hormone on hand grip strength and cognitive function in the elderly Edy Parwanto; David Tjahyadi; Husnun Amalia; Nany Hairunisa; Hosea Jaya Edy; Ashaolu Victoria Oladimeji; Noureddine Djebli
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.329-345

Abstract

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.
Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts Nur Ilham Risma Hidayati; Indra Kusuma; Eko Poerwanto
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.283-293

Abstract

BACKGROUNDHuman dermal fibroblast (HDF) cultures can be used as a regenerative agent for wound healing. Fetal bovine serum (FBS) as a culture supplement is derived from animals, therefore not being constant in composition, causes variations in research results, thus requiring a substitute such as KnockOut serum replacement (KOSR). This study evaluated the defined KOSR as FBS substitute for HDF culture by measuring the relative expression of basic fibroblast growth factor (bFGF) and keratinocyte growth factor (KGF) messenger RNA (mRNA), HDF cell proliferation, and HDF migration. METHODSHuman dermal fibroblast culture was divided into 2 intervention groups receiving KOSR 5% and KOSR 10%, respectively, and a control group receiving FBS 10%. Reverse transcription polymerase chain reaction (RT-PCR) was used for bFGF and KGF mRNA relative expression at the fifth passage (P5). Cell counting kit-8 (CCK-8) reagent was used for the HDF cell proliferation assay at P5 and the scratch assay was used for HDF cell migration at P6. Data were analyzed using dependent t-test, One-way ANOVA, or Kruskal-Wallis test. RESULTSThere were no significant differences in bFGF and KGF mRNA relative expression and HDF migration velocity between the intervention and control groups (p>0.05 and p>0.05, respectively). The doubling time of the KOSR 5% group showed no significant difference (p>0.05), but KOSR 10% and FBS 10% showed significant differences between treatment days 2-6 and treatment days 6-10 (p<0.05). CONCLUSIONSThe KOSR 10% was comparable to FBS 10% in supporting bFGF and KGF mRNA relative expression, HDF cell proliferation, and HDF cell migration in HDF culture.
Indwelling ureteral stenting negatively impacts sexual function transiently after endourological procedure among adult male and female patients: a prospective cohort study Ferdy Bangun Kangsaputra; Nur Budiyono; Sakti Ronggowardhana Brodjonegoro
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.276-282

Abstract

BackgroundUreteral stents, which are widely used after endourological procedures, cause adverse effects. However, its potential impact on sexual function remains unclear in patients undergoing ureteral stenting. This study aimed to investigate sexual function in adult male and female patients undergoing endourological procedures involving ureteral stent placement. MethodsWe conducted a prospective cohort study in a double tertiary care hospital setting with 103 selected patients (53 male and 50 female). We used a self-administered questionnaire-based survey, namely the Indonesian version of the 5-item International Index of Erectile Function (IIEF-5) for male patients and the Indonesian Female Sexual Function Index (Indonesian FSFI) for female patients at three different times (pre-stenting, four weeks after stenting, and four weeks after stent removal). A paired t-test or Wilcoxon test was used for data analysis. ResultsIn the male group, significant changes were noted in the four IIEF-5 domains and overall IIEF-5 scores at pre-stenting and four weeks after stenting (p =0.000). The female group showed significant differences for all FSFI domains and overall FSFI scores at pre-stenting and four weeks after stenting (p=0.000). Most patients in both groups recovered sexual function four weeks after stent removal, as indicated by insignificant differences in the overall IIEF-5 and FSFI scores at pre-stenting and four weeks after stent removal. ConclusionUreteral stenting led to significant but transient sexual dysfunction in both groups at four weeks after stenting. In this regard, male and female patients need to receive counselling and attention, that they may experience temporal sexual dysfunction at least for 4 weeks.
Evaluation of blood metal levels of hockey teams after playing on synthetic turf fields Esin GULLU; Abdulsamet EFDAL; Abdullah GULLU; Ihsan CETIN
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.255-262

Abstract

Background Artificial turf fields are widely used as an alternative to natural grass in many areas such as parks, playgrounds, and playing fields. In this study, we aimed to evaluate the toxicological effects of the chemicals contained in the fields consisting of artificial turf and crumb rubber on the blood metal levels in field hockey players. MethodsA cross-sectional study was conducted involving 28 apparently healthy men aged 20-25 years who participated in this study voluntarily. They consisted of 17 field hockey athletes [athlete group (AG)] and 11 sedentary males [control group (CG)]. Before and after the 7-day tournament, blood samples were taken from AG and CG to measure mercury, arsenic, aluminum, lead, zinc, magnesium and iron levels. An independent t-test was used to analyze the data. ResultsIn comparisons between CG and AG, the magnesium level of AG before the tournament was higher, while the iron and mercury levels were significantly lower (p<0.05). In intragroup comparisons, a significant increase was observed in the post-tournament magnesium and iron variables in the AG group (p<0.05). In post-tournament intergroup comparisons, increases in the Mg and decreases in the Hg variables of AG were significant (p<0.05). ConclusionIt is thought that as a result of the tournament on fields with synthetic grass surfaces, the male field hockey players in the 20-25 age group were toxicologically not affected by the harmful heavy metals present in these fields, because the Hg, As, Pb, Zn, Al, Fe, and Mg levels are within the international reference ranges.
Loneliness and depression levels as risk factors of pain in geriatric prostate cancer patients Remziye CICI; Gulay YILMAZEL; Nur Pınar AYAZ
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.294-302

Abstract

BackgroundProstate cancer is the most prevalent malignancy among men, and psychological symptoms may affect many patients. Although much work has been carried out on loneliness, depression, and pain in geriatric prostate cancer patients, far less research has examined their associations. Therefore, the present study explored the association of loneliness and depression with pain in geriatric prostate cancer patients. MethodsA cross-sectional study was conducted involving 83 patients between the ages of 60 and 74 years, who were diagnosed with prostate cancer and were close relatives of students studying at a health sciences university. Data were collected with the Loneliness Scale for the Elderly, Beck Depression Inventory, and Numerical Rating Scale. The duration of prostate diagnosis was evaluated according to patient files. Simple and multiple logistic regression analyses were used to analyze the data. Results It was determined that the median age of the individuals included in the study was 66 years, and the median pain duration of these patients was two years. Severe pain was found in 62.7%, loneliness in 61.4%, and depression in 68.7% of the patients. Duration of diagnosis, loneliness, and depression were significantly associated with pain intensity. Depression increases the risk of pain intensity 3.41 times among patients (aOR=3.41;95% C.I.: 3.07-8.16; p=0.038) ConclusionIt was determined that duration of diagnosis, loneliness, and depression levels were risk factors for pain intensity in geriatric prostate cancer patients. Developing interventions for patients' mental states in rehabilitation studies may help alleviate the severity of pain.
Is 'quorum quenching' a promising tool to combat antibiotic-resistant bacteria? Naga Raju Maddela
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.249-250

Abstract

Childhood blindness from surge of advanced stage retinopathy of prematurity in premature infants during the COVID-19 pandemic: a case series Dian Estu Yulia; Diajeng Ayesha Soeharto
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.360-367

Abstract

Background Retinopathy of prematurity (ROP) is a proliferative disease of the ocular retinal vasculature in premature infants, being a leading cause of preventable childhood blindness. The COVID-19 pandemic serves as an additional barrier to access to care and referral, potentially leading to more cases of advanced stage ROP. Although surgery can be done, ROP at this stage is highly associated with poor functional outcome irrespective of surgery. This case series aims to report advanced stage (stage 5) ROP in premature infants during the COVID-19 pandemic. MethodsA retrospective case series of medical records of paediatric patients with ROP was performed at Cipto Mangunkusumo National Referral Hospital between March 1, 2020 and December 31, 2021. This case series included new patients that presented to our clinic from March 2020 to December 2021 with stage 5 ROP. ResultsA total of 19 eyes of 10 patients with stage 5 ROP were included in this study. Mean chronologic age at presentation to our referral centre was 7.0 4.0 months. Upon presentation, all had stage 5 ROP with negative blink reflex to light, and none of the eyes in this cohort underwent surgical intervention. Mean gestational age was 30.3 3.2 weeks and mean birth weight was 1,276.7 366.4 g. ConclusionThere was an observable surge of stage 5 ROP at our referral centre with irreversible blindness. This highlights the need for proper ROP screening in all hospitals in Indonesia to prevent delay in detection and care of advanced stage ROP.
Release of retromalleolar flexor retinaculum and combined flexor digitorum longus and flexor hallucis longus Z-plasty in checkrein deformity: a case report Komang Agung Irianto; Enrico Leonarto; Henry Ricardo Handoyo
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.368-373

Abstract

BackgroundCheckrein deformity is a rare abnormality comprising flexor hallucis longus (FHL) tendon entrapment in the posterior foot due to post-traumatic or ischemic retraction of the FHLtendon following soft tissue trauma. The diagnosis is essentially clinical, but complemented by imaging to rule out unrecognized causes and evaluate the fracture healing process. This case report is the first Indonesian study to describe release of the flexor retinaculum and Z-plasty (lengthening) of flexor digitorum longus (FDL) and FHL tendons through a medial retromalleolar approach to repair the deformity. Case DescriptionWe present the case of a 51-year-old male who complained of clawing of his right first and second toes. The interest of this study lies in the fact that this patient had never experienced ankle or distal tibial fractures, only a trivial injury two years back when the patient kicked a stone at work and had a bruise on his right second toe with no fracture. Exploration of FHL tendons was performed at the level of the midfoot. The patient was planned for surgery with a medial retromalleolar ankle approach, which facilitates the release of the flexor retinaculum, in conjunction with a Z-tenotomy on the FHL and FDL tendons. ConclusionA correction was achieved, and two months post-surgery there were no recurrences of the deformity. However, this surgical procedure requires more cases to support an evaluation of its effectiveness. We suggest that exploration at the ankle and midfoot should be the primary surgical intervention in similar cases of checkrein deformity.
Secretome hypoxia-mesenchymal stem cells decrease tumor necrosis factor-α and interleukin-18 in kidney of type 2 diabetes mellitus model rats Risky Chandra Satria Irawan; Agung Putra; Trisnadi Setyo; Shabrina Syifa Ghaisani; Nurul Hidayah
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.320-328

Abstract

Background Type 2 diabetes mellitus (T2DM) is a chronic disease that affects millions of people worldwide and associated with an increased risk of kidney damage caused by prolonged inflammation. Secretome hypoxia- mesenchymal stem cells (SH-MSCs) have been investigated as a potential therapy for kidney inflammation in T2DM, due to their immunomodulatory properties and ability to promote tissue repair. In this study, we investigated the effects of SH-MSCs on tumor necrosis α (TNF-á) and interleukin-18 (IL-18) in the kidney of the T2DM model rats. MethodsA post-test-only control group involving 24 male Wistar rats. The rats were treated with a high-fat diet (HFD) for 4 weeks and streptozotocin-nicotinamide with sucrose solution for 5 days to induce T2DM animal models. Rats were randomly divided into four groups: healthy, control, and groups treated with SH-MSCs T1 and T2, with doses of 250 µL and 500 µL, respectively. TNF-α and IL-18 gene expression was measured by real time polymerase chain reaction (RT-PCR). One Way ANOVA and post-hoc LSD tests were used to determine the significant difference against all groups based on their quantitative measurement. ResultsAdministration of the SH-MSCs at a dose of 500µL (T2) was able to significantly reduce TNF-α and IL-18 gene expression when compared to control (T2DM rat without treatment) (p<0.05), but not significantly when compared to healthy and SH-MSC at a dose of 250µL (T1) group (p>0.05). ConclusionThis study demonstrated that the SH-MSCs decreased the levels of proinflammatory cytokines TNF-α and IL-18 gene expression in the kidney of T2DM model rats.

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