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Pharmaceutical Sciences and Research (PSR)

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Published by Universitas Indonesia

ISSN : 24072354 EISSN : 24770612 DOI : https://doi.org/10.7454/psr.v7i4.1076

Core Subject : Health,

Medicine & Pharmacology

Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: Original article Case report Case series Review article Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: Pharmacognosy and Phytochemistry Pharmaceutical Chemistry Pharmaceutical Technology Pharmaceutical Biotechnology Clinical Pharmacy Pharmacology-Toxicology Social and Administrative Pharmacy, including Pharmacoeconomy

Arjuna Subject : Kedokteran - Farmakologi (Medis)

Articles 236 Documents

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Antimicrobial and Cytotoxic Properties of the Ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri Firmansyah Karim; Masteria Yunovilsa Putra; Tri Aryono Hadi; Muhammad Abrar
Pharmaceutical Sciences and Research (PSR) Vol 5, No 2 (2018)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.7454/psr.v5i2.4137

The aim of this research is to investigate antimicrobial and cytotoxic activity from Indonesian ascidians. Extracts prepared from the Indonesian ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri were assessed for anti-microbial and cytotoxic properties. Antibacterial activity of the extracts was tested against two Gram-positive bacteria, viz. Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923, and three Gram-negative bacteria, viz. Escherichia coli ATCC 25922, Vibrio cholerae ATCC 14035 and Pseudomonas aeruginosa ATCC 101454 using the disk diffusion test. Antifungal activity was also tested against Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404. The minimum inhibitory concentrations (MICs) of potential ascidian extracts were determined by the microdilution technique. Cytotoxicity of the extracts was assessed using the brine shrimp lethality bioassay. By comparing the inhibition zones in the disk diffusion test, the most active anti-bacterial activity against Gram-positive bacteria (S. aureus and B. subtilis) was found in the crude extracts of Oxycoryna fascicularis and Didemnum molle. Lissoclinum patella extract showed the highest activity against the Gram-negative bacteria E. coli and V. cholerae. The LC50 values of the crude extracts of Lissoclinum patella, Didemnum molle, Botryllus schlosseri, and Oxycoryna fascicularis were 74.3, 97.2, 114.7 and 132.9 μg/ml, respectively. In our study, the most promising species for anti-microbial and cytotoxic properties are Lissoclinum patella and Didemnum molle.

VALIDASI METODE PENETAPAN KADAR DEHIDROLOVASTATIN DALAM PLASMA IN VITRO DENGAN KCKT Gogok Hariyanto; L.Broto Sugeng Kardono; Umar Mansyur
Pharmaceutical Sciences and Research (PSR) Vol 5, No 2 (2008)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Statins are antihyperlipidemic drugs for lowering LDL-cholesterol level in human blood. They were designed to inhibit HMG CoA reductase in the liver so that the enzyme will not catalyze the transformation of HMG CoA into early precursor of LDL-cholesterol. Dehydrolovastatin is a kind of statins whose structure is analogous to lovastatin (its starting material). The aim of this study was to validate method forin vitro analysis of dehidrolovastatin in plasm. The validation included studies of calibration curve and linearity, LLOQ and selectivity, accuracy, precision, recovery,and stability. Dehidrolovastatin was deteminated by Knauer ® HPLC using UV 2500 detector, Kromasil ® 100-5, C18, 250 mm, 4.6 mm i.d., column. Reversed phase was applied with the optimal condition such as mobile phase acetonitrile and phosphoricacid 0.1 % (75:25), the flow rate of 1.2 mL. minutes -1, simvastatin as internal standard and wavelength 238 nm. Concentrations of sample ranged from 0.013 to0.200 ppm with correlation coefficient of the calibration curves 0,998 and lower limit of quantitation was 0.013 ppm. The results of validation studies fulfilled standard criteria.Keywords : dehydrolovastatin level in plasm, validation, in vitro analysis, high performance liquid chromatography

Stabilitas Fisik dan Efektivitas Sediaan Tabir Surya Kombinasi Oksibenson dan Oktil Metoksisinamat dalam Basis Gel Carbomer 940 dengan Penambahan Asam Glikolat Noorma Rosita; Tutiek Purwanti; Agustin Agustin
Pharmaceutical Sciences and Research (PSR) Vol 7, No 2 (2010)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

To fulfill the consumer expectation, cosmetic industries mostly add glycolic acid aswhitening agent to the sunscreen preparation. The aim of this research was to knowthe effect of glycolic acid addition with the concentration of 8, 10, and 12% w/w onphysical stability and effectiveness of sunscreen product containing oxybenzoneand octyl methoxycinnamate (2: 7% w/w) in carbomer 940 gel. The physical stabilitytest was done by observing physical appearance, pH, and spreading ability during 60day storages on zone IV condition (temperature 30±0.5° and RH 70±2%). The efficacywas determinated base on SPF (Sun Protection Factor) value by spectrophotometer.The result of the physical stability test showed that glycolic acid additionaffects the physical appearance (consistency) of sunscreen product, but pH and spreadingability are relatively stable. The efficacy test result showed that the addition ofglycolic acid has an effect on SPF value of sunscreen product. Product which combinedwith glycolic acid showed a significant increase of SPF value, compared tocontrol formula. The addition of glycolic acid increased SPF value and alter theeffectiveness category from extra protection to maximal protection.Keywords: glycolic acid, oxybenzone, octyl methoxycinnamate, SPF, sunscreen.

Seleksi Galur-Galur Leuconostoc yang Mempunyai Aktivitas Bakteriostatin Terhadap Berbagai Bakteri Indikator Agustina Retnaningsih; Amarila Malik; Maksum Radji
Pharmaceutical Sciences and Research (PSR) Vol 9, No 2 (2012)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Lactid Acid Bacteria (LAB) are known to produce bacteriocins which have antimicrobi-al activity, and possessed to be developed as antibiotic complement. This study aimed tocharacterize bacteriocins activity from Leuconostoc strains isolated previously from localsources, and to optimize pH and incubation temperature as well. A well diffusion agarassay for zone inhibition method and bacteriocin potency assay performing minimum in-hibition concentration (MIC) have been done. Bacterial indicators used in this study areLeu. mesenteroides TISTR 120, and JCM 6124, Staphylococcus aureus FNCC 0047, Lis-teria monocytogenes FNCC 0156, Escherichia coli FNCC 0183, Pseudomonas aeruginosaFNCC 0063, Salmonella typhi FNCC 0165 and Bacillus subtilis FNCC 0061. Catalase,Trypsin and Protease K were also used for confirmation test. Results revealed that bothLeu. mesenteroides MBF2-5 and MBF7-17 possessed bacteriocin activity although againstLeu. mesenteroides TISTR 120 and JCM 6124 indicators strains. The optimum pH forbacteriocin potency assay for both Leuconostoc strains MBF2-5 and MBF7-17 was pH 6,whereas the optimum incubation temperature was 32 oc with MIC value of 90% and 80%,respectively.Keywords: Bacteriocin, lactic acid bacteria, Leuconostoc mesenteroides, MIC

Penetapan Kadar Hidrokortison Asetat dalam Sediaan Krim Mengandung Pengawet Nipagin secara Spektrofotometri Derivatif Orde Pertama Hayun Hayun; Nelly Dhevita Leswara; Luthfi Zarkasih
Pharmaceutical Sciences and Research (PSR) Vol 1, No 2 (2014)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

The simple and rapid spectrophotometric methods were developed for analysis of hydrocortisone acetate in cream pharmaceutical formulations containing nipagin as preservative. Concentration of hydrocortisone acetate was determined by measuring the first derivative absorption (ratio amplitudes) at 257.0 nm (zero crossing for nipagin). The calibration graphs were linear over the range of 4.0-40.0 ppm of hydrocortisone acetate (r= 0.9999). The limit of detection (LOD) and the limit of quantitation (LOQ) were found to be 0.9617 ppm and 3.2050 ppm, respectively. This method had good precision (repeatability and intermediate precision) with RSD < 2.0% where as the means of the recovery data (accuracy) were 102.03±0.14% and 100.23±0.69% for hydrocortisone acetate cream 1% and 2.5%, respectively. The proposed method was applied for the determination of hydrocortisone acetate in three out of four commercial cream formulations samples and the results of label claim were 102.93±0.22%, 108.48±0.19% and 106.67±0.35% for sample A, B and D, respectively. The result of brand C analysis showed to contain more than 110.0% of the labeled amount of hydrocortisone acetate, indicated there was additive other than nipagin in the cream basis to interfer with the hydrocortisone acetate measurements

IDENTIFIKASI SENYAWA ANTIOKSIDAN DALAM SPONS CALLYSPONGIA SP DARI KEPULAUAN SERIBU Endang Hanani; Abdul Munim; Ryany Sekarini
Pharmaceutical Sciences and Research (PSR) Vol 2, No 3 (2005)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Antioxidant activity and identification of antioxidative compounds of Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The sponge was extracted with acetone and the extract was concentrated using rotary vacuum evaporator. DPPH and tiocyanate methods were used to examine the antioxidant activity of the extract. The extract exhibited strong antioxidant activity in DPPH method with IC50 of 41.21 Âµg/ml. Chemical analysis indicated that the antioxidative compound in the sponge was alkaloid group. Key words : Antioxidative activity, Callyspongia sp., Sponges, alkaloid.

EPIDEMIOLOGI DAN DIAGNOSIS DENGUE DI INDONESIA Zilhadia Zilhadia
Pharmaceutical Sciences and Research (PSR) Vol 4, No 3 (2007)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Dengue fever/DF and dengue hemorrhagic fever/DHF is a global public health problem that occured in tropical and subtropical region. Epidemic dengue occurs every years, and it continues to be a major health problem in Indonesia. Due to its asymptomatic nature, a reliable, rapid and accurate dengue diagnosis is needed. Dengue diagnosis method based on molecular dengue virus properties and it will be developed by researcher. Dengue rapid test isnewly method. This article explaine about dengue epidemiology, molecular dengue virus properties, clinical diagnosis, serology diagnosis and progress research of dengue virus.

PENETAPAN KADAR TRIPROLIDINA HIDROKLORIDA DAN PSEUDOEFEDRINA HIDROKLORIDA DALAM SEDIAAN SIRUP OBAT INFLUENZA SECARA KROMATOGRAFI LAPIS TIPIS DENSITOMETRI . Hayun; Nelly D Leswara; Camelia D.P Masrijal
Pharmaceutical Sciences and Research (PSR) Vol 4, No 2 (2007)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

The determination of pseudoephedrine hydrochloride and triprolidine hydro-chloride in influenza syrup medicine has been performed using TLC densitometric method. Pseudoephedrine hydrochloride and triprolidine hydrochloride were extractedusing chloroform at pH 12 from the syrup, and separated using HPTLC silica Kie-selguhr glass plates 60 F 254, 20x10 cm2 as stationary phase, and a mixture of methanol, ammonia and chloroform (40:2:30) as mobile phase. The plates were ana-lyzed using Camag TLC Scanner 3 with UV-detector at 257 nm for pseudoephe-drine hydrochloride and at 290 nm for triprolidine hydrochloride. The results showed that the linearity, limit of detection, and limit of quantitation of the method forpseudoephedrine hydrochloride were 0.9999, 0.0064 µg, and 0.2124 µg respectively; while for triprolidine hydrochloride were 0.9999, 0.0076 µg, and 0.0254 µg respec-tively. The coefficient of variance (CV) of repeatability for the two substances wereless than 2.0%; and the recovery values for pseudoepherine hydrochloride and triprolidine hydrochloride were 99.98 + 1.05% and 99.73 + 1,54% respectively. The result showed that the samples analysed contained pseudoephedrine hydrochloride94.36% of the labeled ammount, and triprolidine hydrochloride 94.44% of the la-beled ammount.Key words : pseudoephedrine hydrochloride, triprolidine hydrochloride, TLC densitometric method.

VALIDASI METODE ANALISIS REBAMIPID DALAM PLASMA IN VITRO SECARA KROMATOGRAFI CAIR KINERJA TINGGI-ULTRAVIOLET Yahdiana Harahap; Nu Alia
Pharmaceutical Sciences and Research (PSR) Vol 6, No 3 (2009)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Rebamipide is antiulcer agent and it is one of the drug that have to be evaluated with bioequivalency test according to Food and Drug Administration (FDA). The objec-tive of this research is to find out the optimum condition of rebamipide in humanplasma in vitro analysis by High Performance Liquid Chromatography (HPLC) with ultraviolet detector, and then the method was validated. The chromatography wascarried out by isocratic technique on a reversed-phase Kromasil® C18 (5 µm, Akzo Nobel), column length was 250 x 4.6 mm, with mobile phase consisted of acetonitrile- phosphate buffer pH 3.0 (40:60) at flow rate of 1.0 ml/min, and detection was performed at wavelength of 230 nm. The sample preparation technique was liquid-liquid extraction by phosphoric acid and ethyl acetate. Carbamazepine was used as the internal standard. The method was valid according to FDA in Bioanalitycal Method Validation, with coefficient correlation of 0.9993 and linear in the range concentra-tion of 0.04 – 1.2 µg/ml, the lower limit of quantitation was 42.0 ng/ml, precisionless than 6% and recovery percentage was 90.32 to 113.45%. Rebamipide in plasma was stable for 14 days storage in -200C.Keyword : Validation, HPLC, rebamipide, carbamazepine, plasma in vitro.

Faktor Penentu Permeasi Transdermal:Tinjauan Berdasarkan Hukum Fick I Annas Binarjo
Pharmaceutical Sciences and Research (PSR) Vol 9, No 3 (2012)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Transdermal drug delivery may be an alternative to overcome the problems of oral administration, such as fluctuations drugconcentration in the blood. Only several drugs have a good transdermal permeation ability, thus some efforts are needed to improve it. Transdermal permeation follows pasive diffusion mechanism. Therefore, Fick Law I must be concidered in improving transdermal permeation of the drug. This review aims to determine the factors associated with the transdermal permeation based on Fick's law I. Chemical compounds to enhance transdermal permeation (Chemical penetration enhancers) can be used to increase the diffusion coefficient (D), the partition coefficient (k), the rate of drug in the donor compartment (Cd), membrane thickness (h), and extensive contact of drug with the skin (S).

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Contact Name
Hardiyono

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hardiyono@hangtuah.ac.id

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+6221-27608403

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psr@farmasi.ui.ac.id

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3rd Floor, A Building, Rumpun Ilmu Kesehatan Kampus Baru UI Depok, 16424, Indonesia

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Jawa barat

INDONESIA