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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Search results for , issue "Vol 7, No 2 (2022)" : 9 Documents clear
Meta-Analysis of the Effects of Diet and Physical Activity on HbA1c in Type II Diabetes Mellitus Patients
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.241 KB)

Abstract

Background: Type II Diabetes Mellitus is still a global health problem. The prevalence of diabetes has increased over the decades due to the increased incidence of Type II DM. This study aims to analyze the effectiveness of diet therapy and physical activity on HbA1c levels in type II DM patients.Subject and Method: This study is a systematic and meta-analysis study, with the following PICO Population = Patients diagnosed with type II DM. Intervention= High physical activity and diet therapy. Comparison = Low physical activity and no diet. Outcome= HbA1c level. The articles used in this study were obtained from several databases, including PubMed, Science Direct, Scopus, Clinical Key, and Google Scholar. The keywords used were: “tertiary prevention and DM”, “diet”, “physical activity”, “diet and DM” “physical activity and DM”, “diet and tertiary prevention and DM”. The inclusion criteria were full-text articles, experimental study design using randomized controlled trial (RCT). Articles were collected using PRISMA flow diagram. Articles were analyzed using Review Manager 5.3 application.Results: A meta-analysis of 9 articles on the effectiveness of diet therapy on HbA1c levels from Spain, the United States, Japan, the United Kingdom, and Israel concluded that Type II DM patients on diet therapy had an HbA1c level of 0.49 units compared to Type II DM patients without treatment, and the results were statistically significant (SMD= -0.49; 95% CI= -0.56 to -0.42; p < 0.001). A meta-analysis of 9 articles on the effectiveness of physical activity on HbA1c levels from the United States, Australia, Italy, and India concluded that Type II DM patients with high physical activity had HbA1c levels by 0.81 units lower than Type II DM patients with low physical activity, and the results were statistically significant (SMD= -0.81; 95% CI= -1.20 to -0.43; p < 0.001).Conclusion: Diet therapy and high physical activity reduce HbA1c levels in type II DM patients.Keywords: Physical activity, diet, HbA1c, type II DMCorrespondence: Utari Kusumaningrum. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: utariikusuma@gmail.com. Mobile: +6289636061501.Indonesian Journal of Medicine (2022), 07(02): 172-187https://doi.org/10.26911/theijmed.2022.07.02.06
Probiotics and Its Effects on the Cognitive Development in Children: A Meta-Analysis
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Due to its high morbidity and mortality rate, diarrhea is still a major health problem among children, particularly toddlers, in developing countries. One of the causes of diarrhea in children is the side effect of antibiotics or known as antibiotic-associated diarrhea (AAD). Evidences of studies conducted in several countries indicated the high use of antibiotics among children that put the group at a high risk of enduring AAD. Probiotics has shown efficacy in preventing and curing various medical conditions, especially those involving digestive tract in children.Subject and Method: It was a systematic review and meta- analisis study. Data collection was conducted by obtaining from databases, namely: Google Scholar, PubMed, Scopus and Science Direct. The study was analyzed by using RevMan 5.3 software. Inclusion criteria used were full paper in English with Randomized controlled trial design during the period of 2000-2022. Keywords used were “Probiotic” AND “Antibiotic Associated Antibiotic” AND “Child” AND “Randomized Controlled Trial”.Results: Meta-analisis was conducted to 9 primary studies from several countries such as Poland, Italy, Korea, Iran, and Australia. Mata-analysis concludes that there were effects of probiotics toward antibiotic-associated diarrhea. Children who were given probiotics had one-third time risk of diarrhea episodes compared to those who were not given probiotics (RR= 0.32; 95% CI= 0.23 to 0.44; p<0.001). Heterogeneity of between-study effect estimates of the meta-analysis data was (I2= 0%; p= 0.096) therefore, calculation of effect estimates was written by using fixed effect approach. Funnel plot did not identify the occurrence of publication bias out of the meta-analysis. Therefore, the funnel plot did not identify the occurrence of publication bias.Conclusion: Probiotics have effects in reducing antibiotics-associated diarrhea incidences in children.Keywords: probiotics, diarrhea, antibiotics.Correspondence:Anggraini Ambarsari. Masters Program in Public Health, Sebelas Maret University. Jalan Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: Aanggraini.ambarsari29@gmail.com. Mobile: 085600184363Indonesian Journal of Medicine (2022), 07(02): 232-241https://doi.org/10.26911/theijmed.2022.07.02.11
Reduction of Fructosamine Levels after Ramadan Fasting in Children with Type 1 Diabetes Mellitus
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Ramadan fasting is one religious challenge for children with type 1 diabetes mellitus (T1DM) which required specific management and strict monitoring. Fructosamine, which reflects glycemic control within 2-3 weeks, is an ideal parameter of glycemic control in Ramadan fasting. This study aimed to analyzed the effect of Ramadan fasting on fructosamine level of children with T1DM.Subjects and Method: This prospective cohort study included children aged under 18 years old diagnosed wit T1DM for >6 months at Dr. Soetomo Hospital, Surabaya, Indonesia in Ramadan 1438 H (May-June 2017). The independent variable from this study was Ramadhan fasting and the depen­dent variables were fructosamine and HbA1c. The sampling technique was total sampling. Forty-two children were included and devided into 27 children in the fasting and 15 children in the non-fasting group. Fructosamine and HbA1c levels were measured before, mid- and after Ramadan and the comparison between groups were analyzed using the independent T-test.Results: The mean age of all the subjects was 8.95 (SD=3.2) years old, 47.6% were males. The mean (SD) HbA1c level of all the subjects was 10.42 (1.16) %. There was a mild reduction of mean fructosamine level after Ramadan in the fasting group. There was no significat differece I fructsamie level before (Mean= 556.8; SD= 180.39; p= 0.620), mid (Mean= 568.07; SD= 175.37; p= 0.520), and after Ramadhan between groups (Mean= 539.41; SD= 173.04; p= 0.410) respectively. The average fructosamine levels after Ramadan was positively and strongly related to HbA1c (r=0.69; p<0.001). There was no case of severe hypoglycemia and diabetic ketoacidosis in both groups.Conclusion: There is a reduction of mean fructosamine level after Ramadan fasting in children with T1DM although it isn’t statistically significant.Keywords: type 1 diabetes, children, fasting, Ramadan, fructosamineCorrespondence: Nur Rochmah. Department of Child Health, Dr. Soetomo General Hospital/ Faculty of Medicine, Universitas Airlangga. Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, East Java, Indonesia, 60286. Number: +6281703501118. Email: drnurrochmah@gmail.com.Indonesian Journal of Medicine (2022), 07(02): 131-137https://doi.org/10.26911/theijmed.2022.07.02.02
Effect of Core Stability Exercise in Preventing Diastasis Recti Abdominis among Normal Birth Delivery of Postpartum Mothers: Meta-Analysis
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Diastasis Recti Abdominis (DRA) is a separation that occurs in the abdominal muscles, namely between the two rectus abdominis muscles. This separation is precisely in the linea alba which is the midline of the abdomen. DRA is characterized by two things, namely the widening of the inter-recti distance (IRD) and the appearance of a bulge in the abdomen. This is due to stretching and weakness of the linea alba. This study aims to analyze the effect of core stability exercise on reducing diastasis recti abdominis in normal postpartum mothers based on the results of a number of previous primary studies.Subjects and Method: This study uses a meta-analysis method with articles searched using the search keywords "Core stability exercise" AND "diastasis recti abdominis" OR "normal post partum" OR "caliper" OR "ultrasonography" OR "Randomized Controlled Trial" OR "RCT" from PubMed, Google Scholar and Scopus and processed using RevMan 5.3.Results: 9 RCT articles that fit into the inclusion criteria, with a total of 319 samples. Normal post­partum mothers with diastasis recti abdominis who received core stability exercise had an average caliper score of 4.71 units lower than those without core stability exercise, and the effect was statistically significant (SMD= -4.71; 95% CI -8.05 to -1.37; p= 0.060). Normal postpartum mothers with diastasis recti abdominis who received core stability exercise had an average ultrasound score of 0.80 units lower than those without core stability exercise, and the effect was statistically significant (SMD= -0.80; 95% CI -1.62 to 0.02; p= 0.060). In other words, core stability exercise is effective in reducing diastasis recti abdominis in normal postpartum mothers.Conclusion: Core stability exercise has an effect on reducing diastasis recti abdominis in mothers after normal delivery.Keywords: post partum, diastasis recti abdominis, core stability exercise, calipers, ultrasoundCorrespondence: Feny Oktaviyani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: fenyokta89@gmail.com. Mobile: +6281312500­575.Indonesian Journal of Medicine (2022), 07(02): 188-199https://doi.org/10.26911/theijmed.2022.07.02.07
Meta-Analysis the Effect of Aquatic Therapy on Functional Ability in Patients with Knee Osteoarthritis
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Knee OA can affect mobility in the elderly causing pain and impaired functional ability. This study aims to analyze the effect of aquatic therapy on functional ability in knee osteo­arthritis patients based on the results of a number of previous primary studies..Subject and Method: This study was conducted using a meta-analysis method with articles searched using the search keywords "knee osteoarthritis" OR "osteoarthritis genu" AND "aquatic therapy" OR "hydrotherapy" OR "water exercise" AND "functional ability" OR "WOMAC" AND "Randomized Controlled Trial” OR “RCT” from PubMed, google scholar and science direct and processed using RevMan 5.3.Results: 9 RCT articles that fit into the inclusion criteria, with a total of 573 samples. Knee OA patients receiving aquatic therapy had a mean WOMAC score of 1.22 units lower than those without aquatic therapy, and the effect was statistically significant (SMD = -1.22; 95% CI -2.03 to -0.41; p = 0.003). In other words, aquatic therapy is effective in improving functional ability in knee OA patients.Conclusion: Aquatic therapy has an effect on increasing functional ability in knee osteoarthritis patients.Keywords: Osteoarthritis, aquatic therapy, WOMAC indexCorrespondence: Wita Hana Puspita. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: wita.tj0408@gmail.com. Mobile: +628164837959.Indonesian Journal of Medicine (2022), 07(02): 138-149https://doi.org/10.26911/theijmed.2022.07.02.03
Profile of Cognitive Impairement in Patients with Brain Tumors in Dr. Moewardi Hospital, Surakarta
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Brain tumor is a disease that is difficult to treat and causes high morbidity and morta¬lity. One of the clinical manifestations of brain tumors is cognitive impairment which is the most common neurological problem. The aim of this study is to determine the profile of cognitive impairment in patients with brain tumors.Subjects and Method: The design of this study was a retrospective cross-sectional using secondary data from the Neurology Polyclinic of RSUD Dr. Moewardi in January 2021-March 2022. The subject was diagnosed with a brain tumor based on anamnesis, physical examination, and neuroimaging. Cognitive impairment was inferred through the MoCA-Ina test. The analysis used was univariate descriptive analysis, independent T test, Mann-Whitney test, and Pearson correlation test.Results: There were 29 subjects with a mean MoCA-Ina score (17.97). Primary brain tumors (79.3%), more than metastatic tumors. The majority of patients were diagnosed with meningioma (55.2%). This study showed that there were differences in abstraction scores (p=0.015) and total MoCA-Ina scores (p=0.042) between patients with tumors located in the temporal lobe and non- temporal lobe; differences in abstraction scores (p=0.034) and orientation scores (p=0.042) between patients with supratentorial and infratentorial tumors; and differences in memory scores (p=0.028) between patients with and without radiation history. In addition, this study also found an association between the number of lobes affected by brain tumors with attention score (p=0.027; r=-0.409), abstraction score (p=0.004; r=-0.524), orientation score (p=0.021; r=-0.426), and the total score of MoCA-Ina (p=0.018, r=-0.435).Conclusion: There is an association between brain tumors and cognitive impairment which is concluded through the MoCA-Ina test. The clinical manifestations of cognitive impairment in the patient are in accordance with the neuroanatomical function of the brain affected by the lesion.Keywords: Cognitive, Tumor, MoCA-InaCorrespondence: Maria Yosita Ayu Hapsari. Department of Neurology, Faculty of Medicine, Universitas Sebelas Maret/ Moewardi Hospital, Indonesia. Email: ayositahapsari@gmail.com. Phone: 0813 3155 5412.Indonesian Journal of Medicine (2022), 07(02): 242-250https://doi.org/10.26911/theijmed.2022.07.02.12
Meta-Analysis the Effectiveness of Ivermectin Use on the Length of Stay in Inpatients of COVID-19
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: COVID-19 is a common problem in global health. COVID-19 is a disease that infects the respiratory tract caused by the Coronavirus virus. Symptoms range from mild to severe and life-threatening pneumonia can occur. At the beginning of the PSBB, information circulated that Ivemectin could treat COVID-19 infections. Ivermectin is an antiparasitic drug that can be used as prophylaxis and therapy for coronavirus disease 2019. Ivermectin is an alternative therapy for COVID-19 because there is a previous drug, chloroquine, which can be used to treat COVID-19. This study aims to estimate the effectiveness of Ivermectin on the duration of hospitalization of patients with COVID-19 based on the results of previous similar studies.Subjects and Method: This study is a meta-analysis with the following PICO, population: COVID-19 patients. Intervention: ivermectin. Comparison: standard therapy. Outcome: shorter duration of hospital stay. Meta-analyses and systematic studies using the PubMed, Scopus, Scholar, Springlink, Cochrane, Clinical Key, and Science Direct databases. Keywords using Ivermectin AND RCT AND COVID-19 AND “Coronavirus Disease” AND “NCOV disease” AND “COVID-19 treatment”. The article under study is a full-text article with a randomized controlled clinical trial (RCT) study design. Articles were collected using PRISMA diagrams and analyzed using Review Manager 5.3.Results A total of 9 Randomized Control Trial (RCT) studies from Europe, America, Asia and Africa were selected for systematic review and meta-analysis. COVID-19 patients receiving Ivermectin therapy decreased the duration of hospital stay by 1.52 units compared to standard therapy and this result was statistically significant (SMD= -1.52; 95% CI= -2.34 to -0.70; p= 0.003).Conclusion: Ivermectin can reduce the duration of hospital stay for COVID-19 patients.Keywords: COVID-19, ivermectin, duration hospital stayCorrespondence: Masromi Hendria Wijayanto. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: masromi­hendria@gmail.com. Mobile: 0895402471549.Indonesian Journal of Medicine (2022), 07(02): 200-208https://doi.org/10.26911/theijmed.2022.07.02.08
The Effect of High Knowledge on Diabetes Type 2 and Strong Belief in Medicine with Non-Adherence of Anti Diabetic Medication: A Meta-Analysis
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: By 2045, the number of people with diabetes mellitus (DM) was expected to increase from 424.9 million in 2017. Healthcare professionals have had a difficult time managing diabetes because of nonadherence to therapy. Additionally, the efforts made to clarify and enhance patient adherence to their medication are not always successful. This study investigated the factors such as high knowledge on diabetes type 2 and strong belief in medicine that lead to medication non-adherence in adults.Subjects and Method: This article was a systematic review and meta-analysis study conducted by searching for articles from online databases such as EBSCO, ProQuest, and PubMed. Popula­tions: adults with diabetes mellitus; Intervention: a strong belief in anti-diabetic medication and high knowledge of diabetes mellitus; Comparison: a weak belief or none in anti-diabetic medication and little knowledge of diabetes mellitus; Outcome: non-adherence of anti-diabetic medication.  The independen variables is strong belief and high knowledge, the dependen variable is non-adherence to anti-diabetic medication. The inclusion criteria for this study were full articles using a cross-sectional study, with the publication year until 2022. We conduct the analysis using RevMan 5.3 software.Results: A total of 6 articles reviewed in the meta-analysis (consisted 4 articles in each variables), from countries: Ethiopia,  Australia, Uganda, Iran,  Palestine and  China, showed that respondents with strong belief in anti-diabetic medicines (aOR= 0.66; 95% CI= 0.48 to 0.90; p= 0.008) and high knowledge of diabetes mellitus (aOR= 0.85; 95% CI= 0.79 to 0.93; p= 0.0005) had lower level of non-adherence to anti-diabetic medication.Conclusion: A strong belief in anti-diabetic medicines and high knowledge of diabetes mellitus can lower non-adherence to anti-diabetic medication.Keywords: diabetes mellitus type 2, medication adherence, predictorsCorrespondence: Sri Iswahyuni. Study Program of Nursing, School of Health Sciences Mamba’ul ‘Ulum Surakarta.  Jl. Ring Road 03, Surakarta 57127, Jawa Tengah. Email: iswahyunisri@yahoo.co.id. Mobile: +62 815-6720-715.Indonesian Journal of Medicine (2022), 07(02): 150-160https://doi.org/10.26911/theijmed.2022.07.02.04 
Meta-Analysis Effectiveness of Massage on Spasticity in Children with Cerebral Palsy
Indonesian Journal of Medicine Vol 7, No 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Children with spastic cerebral palsy generally experience spasticity in the upper and lower extremities. Spasticity is stiffness that occurs due to damage to the central nervous system caused during the child's growth and development from prenatal to postnatal. Spasticity can be controlled with intervention. The purpose of this study is to analyze, and estimate the effectiveness of massage for spasticity in children with cerebral palsy.Subjects and Method: This study uses a meta-analysis study design with PICO as follows: P= children with cerebral palsy, I= massage, C= non massage, O= Modified Ashworth Scale (MAS). The article search process was carried out between 2000-2020 using databases from PubMed, Google Scholar, PEDro, NCBI. Based on the database, there were 9 articles that met the inclusion criteria. This study involved 817 articles. The analysis was performed using Review Manager software (RevMan 5.3).Results A total of 9 Randomized Control Trial (RCT) studies from Europe, America, Asia and Africa were selected for systematic review and meta-analysis. COVID-19 patients receiving Ivermectin therapy decreased the duration of hospital stay by 1.52 units compared to standard therapy and this result was statistically significant (SMD= -1.52; 95% CI= -2.34 to -0.70; p= 0.003).Conclusion: Ivermectin can reduce the duration of hospital stay for COVID-19 patients.Keywords: Massage, cerebral palsy, Modified Ashworth Scale, meta analisisCorrespondence: Salma Muazarroh. Masters Program in Public Health. Universitas Sebelas Maret, Jl.Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: salma.azza@gmail.com. Mobile: 085642431178.Indonesian Journal of Medicine (2022), 07(02): 209-218https://doi.org/10.26911/theijmed.2022.07.02.09

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