cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rifki Febriansah
Contact Email
pharmrep1000@gmail.com
Phone
-
Journal Mail Official
pharmrep1000@gmail.com
Editorial Address
Jl. RS Fatmawati No 1. Pondok Labu Jakarta Selatan, 12450
Location
Unknown,
Unknown
INDONESIA
Pharmacy Reports
Published by Indonesian Young Scientist Group
ISSN : -     EISSN : 27989798     DOI : https://doi.org/10.51511/pr.2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmacy Reports is an open-access journal publishing peer-reviewed research in the pharmacy field, covering topics in pharmaceutics, biomedicine, pharmaceutical chemistry, bioinformatics, natural product, pharmacology and toxicology, and clinical pharmacy. Pharmacy Reports invites you to submit papers, covering topics in: pharmaceutics (pharmaceutical technology, drug delivery system), biomedicine (molecular biology, biochemistry, immunology, microbiology, biotechnology), pharmaceutical chemistry (analytical chemistry, medicinal chemistry: drug design, drug synthesis, pharmacochemistry, bioinformatic), natural product (fractionation, isolation, purification, and elucidation), pharmacology and toxicology (pharmacokinetics, toxicology), clinical pharmacy (therapeutic drug monitoring, adverse drug reaction, drug interaction), pharmaceutical industry, pharmacy education, community service related to pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 22 Documents
 1   2   3 
Molecular mechanism of glucocorticoid-induced hyperglycemia Destika Ambar Sari; Galih Samodra; Ikhwan Yuda Kusuma
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.572 KB) | DOI: 10.51511/pr.1

Abstract

Glucocorticoids are widely used as strong anti-inflammatory and immunosuppressive drugs to treat various diseases. However, the use of glucocorticoids can cause several side effects, such as hyperglycemia. This review aims to discuss the effect of glucocorticoids on increasing glucose in molecular levels based on literature studies. A literature searching was carried out on the PubMed, Science Direct, and Google Scholar databases published in 2010-2020. Glucocorticoids can cause an increase in blood glucose levels by several mechanisms. In the liver, glucocorticoids increase endogenous plasma glucose and stimulate gluconeogenesis. Glucocorticoids increase the production of non-esterified fatty acids which affect the signal transduction of insulin receptor substrate-1 in skeletal muscle. In adipose, glucocorticoids increase lipolysis and visceral adiposity through increased transcription and expression of protein adipose triglyceride lipase and hormone-sensitive lipase. In pancreatic beta cells, glucocorticoids directly inhibit the beta cell response to glucose through the role of protein kinase B and protein kinase C. At the molecular level, glucocorticoids can cause hyperglycemia through mechanisms in the liver, skeletal muscle tissue, adipose tissue, and pancreatic beta cells.
Potential of pharmacological and herbal for COVID-19: a narrative review Syahrul Tuba; Tesia Aisyah Rahmania
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.051 KB) | DOI: 10.51511/pr.2

Abstract

The pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs in the prevention and treatment process. At present, there is no proven therapy for this disease, although therapeutic approaches continue to be carried out using traditional medicines (herbal) and pharmacological therapy. Information about SARS-CoV-2 virology has rapidly developed and scientists try to provide a number of potential drugs. Remdesivir has strong in vitro activity against SARS-CoV-2. Several potential drugs are currently underway in a clinical trial. Chloroquine, hydroxychloroquine, and oseltamivir have not been proven to have efficacy, and the benefits of corticosteroids are still diverse. Current clinical evidence does not support the termination of angiotensin-converting enzyme 2 (ACE2) inhibitors or angiotensin receptor blockers, coagulation therapy in patients with COVID-19 concomitant with comorbidities.
The effect of aspirin therapy on the increasing of Barthel Index score in stroke patients Ilham Alifiar; Hilda Fitria Kamal; Yedy Purwandy Sukmawan
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.3

Abstract

Stroke, a disorder of nervous system function, is caused by impaired blood circulation to the brain. Post-stroke patients often receive aspirin therapy, yet many still require assistance from others for daily activities. This study aimed to evaluate the impact of aspirin therapy on functional improvement in stroke patients at RSUD Dr. Soekardjo Tasikmalaya, using the Barthel Index score as a measure of patients' ability to perform activities of daily living. A retrospective, descriptive observational approach was employed, analyzing data from stroke patients who underwent aspirin therapy between February and May 2019. The study assessed patients' functional status before and after aspirin therapy, focusing on the level of dependence. Pre-test results indicated that 80.97% of patients fell within the mild dependence category, while 19.03% were classified as moderately dependent. After undergoing aspirin therapy, post-test results revealed a substantial improvement in patients’ functional status. Only 4.76% of patients remained in the moderate dependence category, while a remarkable 95.24% transitioned to the independent range. These findings suggest that aspirin therapy may play a crucial role in enhancing the functional recovery of stroke patients, potentially promoting a higher level of independence and improved quality of life.
In silico studies of isatinyl-2-aminobenzoylhydrazone transition metal complexes against cyclin-dependent kinase 6 (CDK6) Yesaya Reformyada Nusantoro; Arif Fadlan
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.076 KB) | DOI: 10.51511/pr.4

Abstract

Cyclin-dependent kinase 6 (CDK6) is an important member of protein kinases, involving in many cellular pathways especialy cell cycle progression. Thus, CDK6 is a promising target in cancer therapy. This report aims to predict inhibiton of CDK6 by some complex compounds by using molecular docking and pharmacological properties analysis. Those compounds are isatinyl-2-aminobenzoylhydrazone (ISABH) and cobalt (II), nickel (II), copper (II), and zinc (II) transition metal complexes. The molecular docking against CDK6 (PDB code: 3NUP) revealed that ISABH/ISABH-transition metal complexes established ligand-protein interaction as expressed by negative binding affinity values. Drug-likeness by SwissADME indicated that ISABH and Ni-ISABH met the Lipinski’s rule of five. Both compounds also showed reasonable pharmacological criteria by admetSAR.
The detection of SARS-CoV-2 using reverse transcription loop-mediated isothermal amplification (RT-LAMP) in developing country Muhammad Rizky Wibowo; Erna Harfiani; Sarmoko Sarmoko; Yudhi Nugraha
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.235 KB) | DOI: 10.51511/pr.9

Abstract

The severe acute respiratory syndrome coronavirus (SARS-CoV-2) has infected the human system resulting in Covid-19, and has spread rapidly worldwide. Therefore, a fast, simple, cost-effective, and accurate detecting tool is required. The standard diagnostic tool of the World Health Organization is the reverse transcription-polymerase chain reaction (RT-PCR). This method detects the presence of viral genetic material in the human body with accurate results. However, it has several limitations in terms of equipment, personnel, duration, and cost. Therefore, a fast, simple, and sensitive alternative detection, is required, one of which is the reverse transcription loop-mediated isothermal amplification (RT-LAMP) that functions under isothermal conditions. This method is battery-driven, hence, easy to move closer to the patient. Conclusively, the RT-LAMP test for SARS CoV-2 diagnosis produces comparable sensitivity to a standard RT-PCR and is more suitable for resource-poor settings, such as rural areas of developing countries.
Eko Aditya Rifai (1989-2021): An outstanding Indonesian young scientist on bioinformatics Taufiq Indra Rukmana
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.061 KB) | DOI: 10.51511/pr.13

Abstract

An outstanding Indonesian young scientist on bioinformatics
Molecular docking of lutein as anti-photoaging agent in silico I Gede Bayu Krisnayana; Putu Dewi Febyani; Ida Ayu Yadnyaningtias Permata Sari; Ni Putu Linda Laksmiani
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.082 KB) | DOI: 10.51511/pr.15

Abstract

The accumulation of UV exposure resulted in the loss of skin elasticity, and the appearance of wrinkles on the skin is commonly known as photoaging. Matrix metalloproteinase-1 (MMP-1) is an enzyme that degrades type I and III fibrillar collagen. This study aims to determine the mechanism of MMP-1 inhibition by lutein, a carotenoid compound with high antioxidant activity, using in silico molecular docking. This study was conducted by optimization of lutein structure using HyperChem 8, preparation of MMP-1 (PDB ID: 966C) using Chimera 1.10.1, validation of the method, and docking lutein against MMP-1 using Autodock 4.2. The results showed lutein had binding energy of -12.28 kcal/mol, lower than RS2 native ligand (-10.83 kcal/mol). The hydrogen bond formed between lutein and MMP-1 through HIS228 residue. To conclude, lutein may be developed as an anti-photoaging agent by inhibiting the MMP-1.
In silico molecular docking of quercetin as anti-colorectal cancer agents by inhibiting LT4AH Made Agus Widiana Saputra; Anak Agung Istri Rani Mahaswari; Ni Ketut Sri Anggreni; Wahyu Nadi Eka Putri; Ni Putu Linda Laksmiani
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.564 KB) | DOI: 10.51511/pr.16

Abstract

Colorectal cancer is a malignant neoplasm originating from the colon or rectum. Overexpression of leukotriene A4 hydrolase (LTA4H) increases the growth of HCT116 colon cancer cells, therefore, this enzyme becomes an attractive target for commercial drug bestatin. Meanwhile, quercetin is a member of flavonoids possessing a wide variety of anticancer. This study aimed to determine the potential of quercetin as anti-colorectal cancer by inhibiting LTA4H through in silico molecular docking. The docking process involved optimizing quercetin structure, preparing LTA4H protein (PDB ID: 3U9W), validating the molecular docking method, and docking quercetin and bestatin on LTA4H. The binding energy of quercetin to LTA4H was -9.57 kcal/mol, while 28P native ligand and bestatin yielded -10.22 kcal/mol and -9.10 kcal/mol, respectively. Based on the binding energy value, quercetin has a potential inhibitory against the LTA4H.
In silico study of lutein as anti-HER-2 receptors in breast cancer treatment Ni Ketut Nitya Cahyani; Wahyu Nadi Eka Putri; I Kadek Diva Dwivayana; Ni Putu Dinda Mirayanti; Ni Putu Linda Laksmiani
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.851 KB) | DOI: 10.51511/pr.17

Abstract

Human Epidermal Receptor-2 (HER-2) overexpression is implicated in breast cancer progression; thus, HER-2 is widely used as the target of anticancer therapy. Lapatinib is a drug widely used to inhibit the HER-2 receptor and tyrosine kinase; however, it develops drug resistance. Lutein is promising to be developed as breast cancer therapy. This study aims to determine the mechanism of inhibition of HER-2 receptor overexpression by lutein in silico. Molecular docking was carried out by optimizing the lutein and lapatinib, preparing of protein target HER-2 (PDB ID 3PP0), validating of molecular docking protocol, and docking of lutein and lapatinib on HER-2. The study resulted in the binding energy of -12.37 kcal/mol, while the binding energy of the native ligand and lapatinib to HER-2 was -10.43 kcal/mol and -12.25 kcal/mol, respectively. The binding energy showed that lutein has potential as breast anticancer suggested from the stronger affinity to HER2.
Molecular docking of gallic acid as anti-photoaging in silico Ni Kadek Diah Parwati Dewi; Kadek Dinda Suryadewi; Diah Mawarni Fitriari; Kadek Lia Andini; Ni Putu Linda Laksmiani
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.053 KB) | DOI: 10.51511/pr.18

Abstract

Skin aging caused by excessive exposure to ultraviolet is known as photoaging. The mechanism underlying skin photoaging relates to collagen degradation in the extracellular matrix (ECM) by overexpression of matrix metalloproteinases-1 (MMP-1). Gallic acid is a phenolic antioxidant found in many types of plants and can be used as an anti-photoaging agent due to its antioxidant activity. This study aims to determine the potential effect of gallic acid as an anti-photoaging against MMP-1 using in silico molecular docking. The stages included gallic acid structure optimization using the HyperChem 8, preparation of protein target MMP-1 (PDB ID: 966C) using the Chimera1.10.1, validation the molecular docking protocol, and docking gallic acid on MMP-1 with the Autodock 1.5.6. The results showed that gallic acid had an affinity for MMP-1 with a binding energy of -6.0 kcal/mol. There are similar amino acid residues in hydrogen bonds between the native ligand RS2 with MMP-1 and gallic acid with MMP-1, namely ALA 182, LEU 181, and HIS 218. The results suggest that gallic acid has the potential as the anti-photoaging agent through the inhibition of the MMP-1 enzyme.

Page 1 of 3 | Total Record : 22

 1   2   3 

Filter by Year

2021 2023


Reset
Filter By Issues
All Issue Vol. 3 No. 1 (2023): Pharmacy Reports (In progress) Vol. 2 No. 2 (2022): Pharmacy Reports Vol. 2 No. 1 (2022): Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports