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Jurnal Natural
Published by Universitas Syiah Kuala
ISSN : 14118513     EISSN : 25414062     DOI : https://doi.org/10.24815/jn
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Immunology & microbiology Neuroscience Physics
Jurnal Natural (JN) aims to publish original research results and reviews on sciences and mathematics. Jurnal Natural (JN) encompasses a broad range of research topics in chemistry, pharmacy, biology, physics, mathematics, statistics, informatic and electronic.
Arjuna Subject : Matematika - Matematika (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Volume 15, Number 2, September 2015" : 6 Documents clear
VALIDATION METHOD OF ULTRAVIOLET SPECTROPHOTOMETRY DETERMINATION OF CONTENT IN AMBROXOL HCl TABLET Tedy Kurniawan Bakri; Fathur Rahman Harun; Misrahanum .; Sadli .
Jurnal Natural Volume 15, Number 2, September 2015
Publisher : Universitas Syiah Kuala

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Abstract

Ambroxol Hydrochloride (Ambroxol HCI) is one of mucolytic drugs that is commonly used to dilute thesecretion within the respiratory tract. This process is completed by lowering the viscosity of mucopolysaccharides, in which its characteristic which is mucolytic within the respiratory tract. This research aims to conduct a validation of the UV spectrophotometry method in determining the level of ambroxol HCI in tablets. This methos is also used to obtain the level of amboxol HCI in tablets that are available in the market. The parameters of the validation are accuracy, precision, limit of detection (LOD), and limit of qualification (LOQ). The samples of ambroxol HCI was consisted of one (1)generic tablet and five (5) from branded tablets from the market. The results of the validation tested gave an accuracy of 99.58% in recovery percentage and Relative Standard Deviation (RSD) of 1.14%. These results showed that this method gave good precision and exactness, with the limit of detection (LOD) 0,1505 µg/ml andlimit of quantification (LOQ) 0,5018 µg/ml. These numbers are obtained from tablets with brands namely Lapimuc® (PT. Lapi) with its level of ambroxol HCI of 99,71 ± 0,64%; Epexol® (PT. Sanbe) with levels of ambroxol HCI of 99,78 ± 0,52%; Mucera® (PT. Otto) with levels of ambroxol HCI of 99,76 ± 0,5239%; Mucos® (PT. Meprofarm) with levels of ambroxol HCI of 99,8 ± 0,75%; Mucopect® (PT. Boehringer Ingelheim) with levels of ambroxol HCI of99,5 ± 0,70%; and finally a generic tablet with the of ambroxolHCl( PT. Phapros) of 99,6 ± 0,59%. All tablets used within this research have conform to the general levels of amboxol HCI in a tablet which is not less than 90.0% and not more that 110% from the number written in the regulation.
APPLYING SEM-EDX TECHNIQUES TO IDENTIFYING THE TYPES OF MINERAL OF JADES (GIOK) TAKENGON, ACEH Julinawati .; Marlina .; Rosnani Nasution; Sheilatina .
Jurnal Natural Volume 15, Number 2, September 2015
Publisher : Universitas Syiah Kuala

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Abstract

Research on the applying of SEM-EDX techniques for identification of minerals types of Jades (Giok) Takengon Aceh has been done within this study. Based on data of SEM-EDX, it showed that Jades (Giok) Takengon is belonging to a mineral of silicate. The types of minerals of Jades (Giok) Takengon are Grossular (Ca3Al2(SiO4)3 from the Garnet group, which is a mineral of nesosilicate and the other type  is lizardite, (Mg3Si2O5(OH)4, from the group Serpentine , which is a mineral of phyllosilicate. SEM-EDX can be used as a technique to identify the types of minerals and the results obtained fast and accurate.
THE CHARACTERIZATION OF SIMPLISIA, ISOLATION AND IDENTIFICATION OF CHEMICAL CONSTITUENS FROM THALLUS Turbinaria decurrens Bory Irma Sari
Jurnal Natural Volume 15, Number 2, September 2015
Publisher : Universitas Syiah Kuala

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Abstract

The characterization of simplisia, phytochemical screening, extraction, isolation and identification of chemical constituens  from thallus Turbinaria decurrens Bory have been carried out. The examination of simplisia characteristics gave the water soluble extract the value of 10.59%, ethanol soluble extract valued at 0.93%, total ash valued at 15.64%, the acid insoluble ash value 0.79% and the water content valued at 8.66%. The result of phytochemical screening showed that there was triterpens/steroids present. The extraction process was carried out by percolation and then was separated by liquid vacum column chromatography. Then by preparative thin layer chromatography isolate B1 was obtained. The analysis of isolate B1 by infra red spectrophotometry showed hydroxyl, aliphatic C-H bond, C=O bond, double bond of C=C, C=O bond, C=H bond of CH3 and CH2, were present. Ultra violet spectrophotometry exhibited a maximum absorption at 242 nm and mass spectrometric fragmentation pattern exhibited that the molecular weight of isolate B1 was 394, it was suspected ergosta -4,7,22 –trien -3 one.
PENENTUAN WAKTU MATI MEMANFAATKAN DERET HOMOLOG ALKILPARABEN PADA RP-HPLC DALAM SISTEM PELARUT METANOL/AIR Mahmudi .; Saiful .; Khairan .; Rinaldi Idroes
Jurnal Natural Volume 15, Number 2, September 2015
Publisher : Universitas Syiah Kuala

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Abstract

Penelitian ini dalam rangka pengembangan dan aplikasi metode penentuan waktu mati (t0) pada Kromatografi Cair dari yang telah pernah dan berhasil diterapkan di GC. Waktu mati merupakan parameter yang sangat penting untuk penentuan parameter lain seperti Faktor kapasitas (k’), retensi relative (tR’) dan indeks retensi kovats (IR), sehingga didapat hasil berupa data base yang bisa diterapkan dalam intrumentasi GC dan RP-HPLC. Penentuan waktu mati dengan menggunakan dua metode yaitu metode iterasi dan metode linearisasi, sehingga didapat nilai indeks retensi kovats dari senyawa uji pada sistem RP-HPLC dengan menggunakan deret homolog alkilparaben. Hasil penelitian menunjukkan deret homolog alkilparaban terbukti dapat digunakan untuk penentuan indeks retensi Kovats  dalam RP-HPLC dengan koefisien korelasi yang sangat baik  terutama pada sistem pelarut MeHO/H2O (90:10). 
WOUND HEALING ACTIVITY OF UNGUENTUM DOSAGE FORM OF ETHANOLIC EXTRACTS OF Areca catechu L. NUT IN Mus musculus albinus Azizah Vonna; Rizky Nurismi; Misrahanum .
Jurnal Natural Volume 15, Number 2, September 2015
Publisher : Universitas Syiah Kuala

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Abstract

The activity test of ethanol extract of betel nut ointment (Areca catechu L.) in wound healing on mice (Mus musculus albinus) has been carried out to determine the ability of the ethanol extract of betel nut ointment in wound healing and determine the concentration which was accelerate the wound healing on mice between 2 concentrations. This experimental research method used completely randomized design (CRD) using 20 mices divided into 4 treatment groups ; ointment base, povidone iodine ointment, ethanol extract of betel nut ointment (SEEBP) 2% and SEEBP 4%. Each treatment groups was tested in the incision which was made along the 15 mm parallel to the spine (Os. Vetebre) with the depth until subcutaneous skin layers. The ointment was applied twice a day for about 21 days and observed changes every day for during the period of observation. The results showed that the average length of time of the scab formation, the scab exfoliation, and the wound healing successively are for the ointment base was 6.6; 10.2 and 18.2 days, povidone iodine ointment was 7; 11.2 and 14.8 days, SEEBP 2% was 5.75; 7.75 and 13.25 days, SEEBP 4% was 4.2; 8.8 and 12.8 days. ANOVA and LSD results of scab formation time showed a significant difference between SEEBP 4% with base ointment and povidone iodine ointment (p 0.05). Results of the exfoliation scab showed a significance difference between SEEBP 2% with base ointment and povidone iodine ointment (p 0.05). The duration of wound healing showed that there was significance difference between SEEBP 2%, SEBP 4% and povidone iodine ointment with ointment base  (p0.05).Thus, betel nut ointment as an effect on healing process. The concentration which can accelerate wound healing in mice is SEEBP 4%.
THE CYTOTOXIC ACTIVITY OF ETHYLACETATEFRACTION OF KERSEN (Muntingia Calabura) LEAVES AGAINST LARVAE SHRIMP ARTEMIA SALINA LEACH Sadli .; Nurul Wahyu Utami; Irma Sari
Jurnal Natural Volume 15, Number 2, September 2015
Publisher : Universitas Syiah Kuala

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Abstract

Abstract. The cytotoxic activity experiment of ethylacetatefraction of kersen (Muntingia calabura) leaves has been carried out using the Brine Shrimp Lethality Test (BSLT) method withf ive concentration variables; they are 10 ppm, 100 ppm, 200 ppm, 500 ppm, and 1000 ppm. The research aims to determine the secondary metabolite; the extract characterization and determine cytotoxic activity of the ethyl acetate fraction of kersen (Muntingia calabura L.) leaves. Extraction was done with maceration method using ethyl acetate solvent to the kersen dried leaves dregs of n-hexane extract and the value of LC50 was determine by using probit analysis. The results of phytochemical screening showed that ethyl acetate fraction of kersen (Muntingia calabura) leaves contained three secondary metabolites, namely tannin, saponin and flavonoid with extract characterization results are the water content of 3.85%3 ± 0.35%, the water soluble extractive of 17.65% ± 0.27%, ethanol soluble extractive of 62.24% ± 0.07%, the total ash value of 0.89%± 0.005%, and acid insoluble ash value of 0.69%± 0.004%. The LC50 value of ethyl acetate fraction of kersen (Muntingia calabura) 84.92 ppm showed that the extract has  cytotoxic activity as medium toxic.

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