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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 4 Documents
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Search results for , issue "Volume 11 Issue 05 (2019) May 2019" : 4 Documents clear
Isolation and Characterization of Probiotics from Various Food Samples P. V. Kamala Kumari
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Probiotics are living organisms that are used as food additives with beneficial effects on the healthy body by setting microbial balance in gastrointestinal tract. Lactic acid bacteria (LAB) as protective cultures are common probiotic organisms that are considered safe due to having specific characteristics. Main genera of LAB are Leuconostoc, Enterococcus, Lactobacillus, Lactococcus, Bifidobacterium, Pediococcus, and Streptococcus. These bacteria cause reduction of gastrointestinal diseases by increasing benefit microorganisms growth and reducing pathogens population mechanisms.Several therapeutic applications for probiotics can be cited protection against traveller's diarrhea, prevention of urogenital diseases, reduction of hypercholesterolemia, alleviation of constipation, prevention of food allergy and osteoporosis and protection against bladder and cancer.  In addition to, probiotics can be prevention or treatment of some disorders, such as lactose malabsorption, irritable bowel syndrome, acute diarrhea, mild forms of inflammatory bowel disease and necrotizing enterocolitis.The present study aims in isolation of probiotics from various daily household food samples available easily in Indian market.
Development of Biocompatible Coatings for Dental Implants Based on Transition Metal Nitrides Alexei Yumashev
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Nitrides are nitrogen (N) compounds with other chemical elements, in particular with transition metals. For transition metal nitrides, the main ones are properties such as homogeneity of the material of nitride products, high electrical conductivity, and high melting points, with hardness exceeding most other known materials. As experimental samples we used ready transition metals alloys from cylinders, 10 mm in diameter, and 20 mm in height. 10 cylinders for each alloy were used. Heating to the required temperatures was carried out using an induction heating furnace. Temperatures were measured with a DT model pyrometer, the measuring range of which ranges from -50 to + 110 °C, with an error of one tenth of a °C. Alloys were studied using electron microscopy, and the hardness of the resulting alloy was also measured. In addition to the samples of implants with a nitride coating, samples of cast products (implants) were produced. 10 samples of each type were made. The nitride film present almost doubled the hardness indices of metals and their alloys. The smallest wear out was observed for gold and platinum samples, the largest - for zirconium, titanium and nickel, 2-3 times more (p≤0.05). The presence of even the thinnest titanium nitride film changed these indicators, as a result of which the wear out level became even lower than that of gold (p≤0.05). The present nitride film prevents the formation of an adsorption layer. Such implants wear out will be slowed down in comparison with metal ones, but without a nitride film, on which an adsorption layer is formed. Along with the preference of titanium physical and chemical properties over other metals and their alloys, the deposition of a titanium nitride film is a necessary property to improve. Titanium has several advantages over other metals, including lower thermal conductivity and resistance to corrosion changes. Titanium nitride gives maximum hardness and maximum wear resistance. Nitride film implants acquire no damage; moreover, nitride spraying can also be used with other types of implants, for example, ceramics. The nitride film gives the metal base additional stability properties, creating a protective layer. The combined use of a titanium implant with titanium nitride spraying (layer thickness no more than 0.1 mm) increases the properties of hardness and wear resistance of implants.Keywords: Nitrogen (N) compounds; Transition metals alloys; Electrical conductivity; Dentistry; Dental implants.
Review on Nanosponge - A Contemporary Drug Delivery Approach Senthil Venkatachalam
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
Publisher : Journal of Global Pharma Technology

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Abstract

An effective operational method of targeted drug delivery system has been an aim for the researchers in the pharmaceutical field for a prolonged time, but it has been mostly discouraged due to the complex chemistry behind in it and the difficulty in designing such a system, Nano sponges are such a delivery method using which targeted delivery to a specific site is possible and extensive researches are being done on nanosponges due to their such activity. Nanosponges as the name suggests are minute sponge like structures with size as small as a virus in which drugs can be incorporated into the voids. Studies have shown that these kind of formulations tends to circulate in the body until the targeted site is reached for the release and further it sticks at the site and releases the drug, since it can be modified to deliver the drug site specifically and hence can be more effective than other methods of delivery, another factor for consideration of nanosponges in targeted delivery is due to their good aqueous solubility which can be used to deliver drugs which are poorly solubleKeywords: Nanosponge, Cyclodextrin, Cross Linking, Functionalized Nanosponges.
Isoniazid Induced Psychosis Sharad Chand
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Isoniazid (INH) is one of the primary drugs used in the treatment of Mycobacterium tuberculosis infection. The common side effects of INH are peripheral neuropathy, hepatitis, rashes. Rarely psychosis, convulsions, and even death have been reported on regular doses of this drug. We present a case of Isoniazid induced psychosis occurring in a 36-year-old female patient was admitted to the general medicine unit for tuberculosis. The case was analyzed for suspected ADR and found to be probable ADR of isoniazid. The drug was discontinued, and antitubercular therapy was changed to modified approach,i.e. (R- Rifampicin 450mg, I- Ethambutol 800mg, S-Streptomycin 750mg and O- Ofloxacin 400mg) which shows clinical improvement in the patient.

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