Parapemikir Jurnal Ilmiah Farmasi
Parapemikir journals based on the results of research in the field of Pharmacy science and community covering Social Behavior and Pharmacy Administration including Pharmacy, Biopharmaceuticals, Drug Submission Systems, Physical Pharmacy, Pharmaceutical Technology, Microbiology and Biotechnology Pharmacy, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry , Pharmaceutical Chemistry, Biological Pharmacy, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicine, Pharmacy Management, Farmakoekonomi, Farmakoepidemiology, Social Pharmacy, Pharmacy Policy.
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<![CDATA[AKTIVITAS ANTIBAKTERI SEDIAAN FOOT SANITIZER SPRAY YANG MENGANDUNG EKSTRAK BIJI KOPI DAN JAHE ]]>
<![CDATA[Joko Santoso]]>;
<![CDATA[Aldi Budi Riyanta]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1300
<![CDATA[The smell of feet is one of the problems of some people caused by sweat mixed with bacteria and moist conditions. S.epidermis bacteria are bacteria that grow in these conditions. Coffee and ginger have synergistic benefits with strong aroma and antibacterial activity so it is preferred. This study is focused to determine the antibacterial inhibition of footsanitizer formula from a combination of coffee and ginger, and produce good physical properties. Maseration with 70% ethanol solvent was used in this study and then formulated. The formulation was evaluated for physical properties such as organoleptic test, pH test, clarity, specific gravity, viscosity. Antibacterial activity test using the well method on S.epidermis. The results showed that foot sanitizer formula had physical properties of clear liquid, distinctive smell of extract, cold taste and pH in accordance with the requirements of topical formulations. Formula III has the highest specific gravity, viscosity and with 0.954 g / ml and 2.3013 Cp. The highest antibacterial activity with 0.348 cm2Keywords: foot sanitizer spray, Coffee, Ginger, Antibacterial, S.epidermis]]>
<![CDATA[PEMBUATAN GEL ANTINYERI DARI MINYAK ATSIRI BUNGA CENGKEH ( Syzygium aromaticum(L.) Merr.&Perry ) ]]>
<![CDATA[Purgiyanti Purgiyanti]]>;
<![CDATA[Rosaria Ika Pratiwi]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1305
<![CDATA[Essential oils of clove flowers (Syzygium aromaticum (L.) Merr. Perry) are known to have properties as analgesic or painkillers. One of the efforts to utilize clove flower essential oil is to be used as an active ingredient in gel preparations. Gel preparations were chosen one of them is because it gives a cold effect on the skin when used on the skin. The material chosen for use as a gel base or gelling agent is CMC-Na. The use of CMC-Na as a base gel was varied with several different concentrations of the three formulas made, namely 3.5%, 5%, and 6.5%. Based on the results of the research analyzed in a theoretical approach by observing and comparing the results with several sources on organoleptic preparations, pH, clarity, dispersion, adhesion, and preference test obtained the best results in formula I with the use of CMC-Na gel base of 3, 5%. Keywords: Gel, Essential oil, Clove Flower, CMC-Na]]>
<![CDATA[HUBUNGAN SIKAP KARYAWAN STIKES AUFA ROYHAN DENGAN PENGGUNAAN KANTONG PLASTIK ]]>
<![CDATA[Nurul Hidayah Nasution]]>;
<![CDATA[Yanna Wari Harahap]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1296
<![CDATA[The use of plastic bags as a place to store goods is a cause of environmental damage and pollution. Health behavior for humans can be seen from the behavior of their environmental health, environmental health behavior is included in health protection for humans, one of which includes behavior towards waste and its management (Notoatmodjo, 2013). STIKES Aufa Royhan with the use of plastic bags. This type of research is analytical research with cross sectional research design. Research conducted at the Aufa Royhan STIKes in Padangsidimpuan City in February - July 2018. The population of this study were all employees at the Aufa Royhan STIKes in Padangsidimpuan City with a sample of 38 people. The independent variable in this study is the temporary employee variable, the dependent variable is the use of plastic bags. Univariate and bivariate data analysis. The results obtained from the Aufa STIkes company have a negative attitude of 84.2% and a positive relationship with attitudes (p = 0.018 and r = 0.385) with the use of plastic bags and have an adequate increase in positive direction which will increase the company's endurance so that many employees have bad actions in using plastic bags. Suggested to respondents to be able to improve positive attitudes by getting information through various media both oral and writtenKeywords:. Attitude, plastic]]>
<![CDATA[IDENTIFIKASI SENYAWA KIMIA FENOLIK DALAM EKSTRAK ETIL ASETAT KULIT BUAH JENGKOL ]]>
<![CDATA[Ahmad sopian]]>;
<![CDATA[Ahmad Darmawan]]>;
<![CDATA[Partomuan Simanjuntak]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1301
<![CDATA[Jengkol (Archidendron pauciflorum (Benth.) I.C Nielsen) is a plant that is already familiar in Indonesia and is widely used as a processed food that is quite popular. One of the underutilized parts of the jengkol plant is the skin. Jengkol fruit peel contains alkaloid compounds, flavonoids, tannins, glycosides, sapoinin and steroids or triterpenoids. The purpose of this study was to determine the content of chemical compounds in ethyl acetate extract of jengkol fruit peel, and to test antioxidant activity by DPPH free radical reduction method.The results of isolation, purification in ethyl acetate extract of jengkol fruit skin does not provide activity as an antioxidant. The results of the analysis using FTIR spectrophotometry, Gas chromatography-Mass Spectrometry (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1HNMR).Keywords: Antioksidan ,archidendron pauiflorum (Benth) I.C Nielsen, jengkol, (1- (2,6-dihydroxy, 4methoxy phenyl) decane-1-one).]]>
<![CDATA[PENGEMBANGAN FORMULASI AROMATERAPI PRODUK HERBAL YANG MENGANDUNG MINYAK ATSIRI BAWANG MERAH (Allium cepa var. aggregatum L ) ]]>
<![CDATA[Heru Nurcahyo]]>;
<![CDATA[Aldi Budi Riyanta]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1280
<![CDATA[The using of alternative and complementary therapies as a treatment is growing rapidly, one of them is aromatherapy. It is an alternative medicine that uses steam from essential oils. The aims of this study is making aromatherapy formulations use the essential oils of onion. The methods are distillationing essential oils use the water, with a sample of shallots. Furthermore, aromatherapy roll on formulations were made and tested include organoleptic and physical test formulation and preference test. The results obtained on average in each distillation amounted to 0.1%, then formulated with a concentration of essential oils of 1%, 2%, 3%, 4% and 5%. Moreover according to the skin pH, the results of the physical and homogeneity test were found a pH 6 that meets the standards, and from the preference test obtained a formula containing 3% of essential oils of shallots which are most in demand by respondentsKeywords: Aromatherapy, onion (Allium cepa var. Aggregatum L), formulation]]>
<![CDATA[Uji Akivitas Imunomodulator Ekstrak Buah Petai (Parkia speciosa Hassk.) terhadap Titer Imunoglobulin (IgG) pada Mencit Balb/c yang Diinduksi dengan SDMD ]]>
<![CDATA[Yithro Serang]]>;
<![CDATA[Ferika Indrasari]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1306
<![CDATA[Immunomodulators are substances or drugs that can modulate the function and activity of the immune system. Most of the medicinal plants that have been studied prove the presence of immunostimulators, while immunosuppressors are still rare. Petai plants can function as antioxidants. There is a close relationship between antioxidants and the immune system giving antioxidants can stimulate and protect the cellular immune system. The purpose of this study was to determine the effect of administration and effective dose of petai fruit (Parkia speciosa Hassk) ethanol extract on increasing IgG titer in Balb / c mice induced by SDMD.This research method was started with Petai extraction and then tested for chemical content. Experimental animals consisted of 25 mice divided into 5 treatment groups, each group consisting of 5 mice. All groups were immunized with 1% SDMD as much as 0.2 ml / 20 g BB on day 8 (after being acclimatized for 7 days) intravenously. Test preparation is given orally for 7 days. On day 14, blood collection from retro orbital plexus was performed to collect serum and examined immunoglobulin G titers with indirect ELISA method.The benefit to be obtained from this study is to prove the ethanol extract of petai fruit (Parkia speciosa Hassk) can increase the immune system against foreign compounds with an increase in IgG titer in Balb / c mice induced by HRD. The results of Petai Fruit Extract Dosage 4.125 mg / KgBB, 8.25 mg / Kg BB and a dose of 16.5 mg / Kg BB give an effect on increasing IgG titers. The dose of 16.5 mg is better than stimouno in increasing IgG levels of mice induced by HRD.Keywords— Petai (Parkia speciosa Hassk), IgG, SDMD,ELISA]]>
<![CDATA[UJI IDENTIFIKASI BAKTERI Esherichia coli PADA JAMU GENDONG KUNYIT ASEM DI KABUPATEN TEGAL ]]>
<![CDATA[Inur Tivani]]>;
<![CDATA[Wilda Amananti]]>;
<![CDATA[Ahmad Sunardi]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1297
<![CDATA[Based on the results of previous studies conducted by researchers in January 2018 showed that the Total Plate Count (ALT) of Jamu Gendong in several villages in Talang sub-district did not meet the quality safety standards (ALT value of more than 104). The high ALT value indicates the presence of bacteria contained in the tamarind tamarind herbal medicine. One of the bacteria that often contaminates food and beverages or drugs is Escherichia coli. E. coli bacteria is a characteristic bacterium contaminated with food or drug samples. The purpose of this study is to test for the presence or absence of E coli bacteria in gedong kunyit asem herbal medicine in Tegal district.The identification test of E. coli bacteria was carried out through two techniques, namely staining and bacterial culture techniques. For coloring techniques, gram coloring tests will be carried out, while bacterial cultures include blood agar plates, and Macconkey agar media.The results showed that gram staining, as well as culture in the media of Blood Agar Plate and Macconkey Agar showed the presence of E. coli bacteria in samples of tamarind ancient tamarind in several villages in Tegal RegencyKeywords: identification test, Escherichia coli bacteria, Jamu genndong, Kunyit asem.]]>
<![CDATA[ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA AKTIF KULIT BATANG KERSEN TERHADAP ARTEMIA SALINA ]]>
<![CDATA[Muhammad Walid]]>;
<![CDATA[Partomuan Simanjuntak]]>;
<![CDATA[Ahmad Darmawan]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1302
<![CDATA[Kersen (Muntingia calabura L.) has been widely used by Indonesian people to cure many diseases such as cancer, diabetes, and antioxidant, antiplateletes, and hepatoprotector. The aim of this research is to discover chemical structure of compounds contained in barks of Kersen (Muntingia calabura L.) based on their toxicity by BSLT (Brine Shrimp Lethality Test) method. Barks of Kersen (Muntingia calabura L.) were macerated by 96% ethanol followed by partition with n-hexane and ethyl acetate successively to give n-hexane, ethyl acetate and water extracts. Ethyl acetate extract which showed highest toxicity (LD50 = 29.00 ppm) was purified by column chromatography using SiO2 with eluents (i). n-hexane - ethyl acetate = 20 : 1 ~ 1 : 1; (ii). n-hexane - ethyl acetate = 5 : 1 to give fraction 4.4.5 as pure isolated compound. Identification was done based on interpretation of infra red spectrophotometry (FT-IR) and liquid chromatography-mass spectra (LC-MS) data, and supported by references investigation. Finally, we were predicted fraction 4.4.5. as 5-(7,8-dimethoxy-3,4-dihydro-2H-1benzopyran-2-yl)-2,3-dimethoxyphenol with LC50 = 5.76 ppmKeywords: Hypoglycemic, Diabetes Mellitus, Momordica charantia, Apium graveolens L.]]>
<![CDATA[PENENTUAN NILAI SPF ( SUN PROTECTION FACTOR) EKSTRAK DAN FRAKSI DAUN KECOMBRANG (ETLINGERA ELATIOR) SECARA IN VITRO MENGGUNAKAN METODE SPEKTROFOTOMETRI ]]>
<![CDATA[Oktariani Pramiastuti]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1281
<![CDATA[Sunlight is needed by all living things to their survival. One of the benefits of sunlight is as sources of energy and making healthy skin and bones. Kecombrang leaf contains phenolic compound which is able to give protection for UV light and have potentially sunscreens. The research aimed to determine of SPF of water extract, n-hexane fraction, and ethyl acetate fraction of kecombrang leaf. The research was in vitro by using spectrophotometry UV-Vis method. The absorbance of extract and fraction of kecombrang leaf was measured at a UV-B light wave length of 290-320 nm. Determination of SPF was based on Mansur equation. Phytochemical test in TLC of water extract, n-hexane fraction, and ethyl acetate fraction was positive for phenol in each. The result showed that water extract of kecombrang leaf had the highest SPF at concentration of 300 ppm numbered 7.30±0.62 with level of extra sunscreens ability; n-hexane fraction of kecombrang leaf had the highest protection activity in a SPF of 17.57±2.49 with level of ultra-sunscreens ability in a concentration of 300 ppm; while ethyl acetate fraction had the highest SPF namely 2.65±0.12 with the minimum protection. The data analysis stated that there was a significant difference between water extract of kecombrang leaf and fractions of n-hexane and ethyl acetate. To sum up, n-hexane fraction of kecombrang leaf had the highest SPF so that it had potentially as sunscreens for UV-B light protectionKeywords: Kecombrang Leaf, SPF, Water Extract, n-hexane fraction, ethyl acetate fraction ]]>
<![CDATA[OPTIMASI FORMULA MATRIKS PATCH TRANSDERMAL EKSTRAK BIJI MAHONI (Swietenia Mahagoni L.) MENGGUNAKAN SIMPLEX LATTICE DESIGN ]]>
<![CDATA[Nurista Dida Ayuningtyas]]>;
<![CDATA[Felisia Bani]]>
<![CDATA[ Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama ]]>
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DOI: 10.30591/pjif.v8i1.1307
<![CDATA[Background: Mahogany seed extract has been widely studied to overcome blood sugar levels in mice in 50 mg / KgBB. The effectiveness of mahogany seed extracts in reducing sugar levels can be used in transdermal patch matrix preparations. Objective: This study is to manufacture preparations of mahogany seed transdermal matrix patches. Method: create a transdermal patch matrix created by optimizing PVA, HPMC, and PVP with the Design Expert version 10 software using the Simplex Lattice Design method. Evaluation formulas include visual index, thickness (cm), net weight (%), shrinkage drying (%), and drug content (%). Results: completion of the Expert Tool version 10 design analysis obtained 14 run. Each formula is optimized and obtained 13-16 visual values, thickness of 0.1007-0.1030 cm, weight of 0.1415-1461 grams, shrinkage of 9.28-15.25%, content medication 60, 28-94.44%. ANOVA analysis produces significant numbers between averages on visual measurements and weights, formulas for optimal determination. The results of the optimal formula formula obtained by the formula PVA: HPMC: PVP with a concentration of 4.92: 1.02: 0.55% and the desire value 0.829. The results of the validation test using the openstat software t test obtained the equation obtained is valid with p value of 0.787 (p 0.05).Keywords: Mahogany seeds, patches, optimization, simplex lattice design]]>
