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Nexus Kedokteran Translasional
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 123 Documents
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Pengaruh Ekstrak Daun Teh (Camellia sinensis, Linn. var. Assamica) terhadap Mortalitas Cacing Ascaris suum, Goeze Ahmad Afiyyuddin N; Cr. Siti Utari; Lilik Wijayanti
Nexus Kedokteran Translasional Vol 2, No 1 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Camellia sinensis, Linn. var. Assamica leaves contain tannin that have been known to have anthelmintic effect. This study aimed to determine the effect of Camellia sinensis, Linn. var. Assamica leaves extract toward death time of Ascaris suum, Goeze. Methods: The study was a laboratory experimental research using the post-test only controlled group design. Subjects were Ascaris suum, Goeze. The sampling technique used was purposive random sampling. Subjects were divided into 7 groups, each group using 4 worms, replication performed 5 times. Saline solution was used in negative control group, pirantel pamoate 5 mg/ml was used in positive control group, while the treatment group used Camellia sinensis, Linn. var. Assamica leaves extract concentration of 50%, 60%, 70%, 80%, and 90%. Worms immersed in the test solution at 25 ml and incubated at 37C. Observations were made every 1 hour and counted dead times of all worms. Data were analyzed with regression linier and probit analysis. Results: Observations of total deaths mean time Ascaris suum, Goeze negative control for 48 hours, the positive control 1 hours 10 minutes, the concentration of 50%, 60%, 70%, 80%, 90% for 10 hours 24 minutes, 9 hours 12 minutes, 7 hours 12 minutes, 5 hours 12 minutes and 4 hours. Linear regression test results show that the variation of the concentration affects long worm death. Probit analysis results obtained LC50 and LT50 Camellia sinensis, Linn. var. Assamica leaves extract is 67,183% and 3 hours 46 minutes. Conclusions: Based on this study, it can be concluded that of Camellia sinensis, Linn. var. Assamica leaves extract affects mortality of Ascaris suum, Goeze, the increasing of extract concentration is inversely proportional with the death time of worms. Keywords: Camellia sinensis, Linn. var. Assamica leaves extract, Ascaris suum, Goeze.
Relationship Between Dermatoglyphic Patterns and ?-Thalassemia Major Disease Nisa'u Luthfi Nur Azizah; Selfi Handayani; Nanang Wiyono
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: ?-Thalassemia major is the most common severe thalassemic disease in the world. Children with ?-Thalassemia major have to be identified and treated soon to prevent the worse prognosis of the disease. One of the screening methods to establish thalassemic diagnosis is by observing dermatoglyphic patterns. The aim of this study was to determine the relationship between dermatoglyphic patterns and ?-Thalassemia major disease. Methods: This study was an observational analytic study with cross sectional design. This study located in Poliklinik Anak and SMF Anak RSUD Dr. Moewardi Surakarta. The sampling technique used purposive sampling based on the characteristics of population that have been known previously. The subjects were 20 patients of ?-Thalassemia major and 20 non- ?-Thalassemia major. Data were obtained through direct scanning the subjects fingerprints using scanner. Statistical analysis used independent-sample t test, Mann-Whitney test and chi square test. Results: From the analysis, this study found there was no significant difference of the ridge count between patients and control group (p > 0.05). However, there was significant difference of the patterns between patients and control group (p < 0.05). The number of whorl patterns in ?-Thalassemia major patients was 53,5%, it greater than that in normal individuals (20,5%). Loop patterns were less frequent in ?-Thalassemia major patients (34%) compared to normal individuals (75,5%). Arch patterns had no significant difference between patients and control group (p > 0.05). Conclusions: There was a significant relationship between dermatoglyphic patterns and ?-Thalassemia major disease. Keywords: ?-thalassemia major, dermatoglyphic, fingerprint
Molecular Docking Analysis of Family Fabaceae Phytochemistry to Estrogen Receptor Alpha Compared to Tamoxifen in Breast Cancer Ega Caesaria Pratama Putra; Riza Novierta Pesik; Ratna Kusumawati
Nexus Kedokteran Translasional Vol 4, No 1 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Breast cancer is the second most common cancer.Estrogen is the risk factor of breast cancer. Estrogen receptor ? is expressed by 50-80% of breast cancer. The mechanism of estrogen is mediated by estrogen receptor ? and estrogen receptor ?. Tamoxifen is a selective estrogen receptor modulators (SERMs) that can be bound to the estrogen receptor ?, therefore prevent bonding between estrogen and estrogen receptor ?. Methods: This research used molecular docking analysis of family Fabaceaes Phytochemistry as an inhibitor of estrogen receptor ? activation. This study was observational bioinformatics study to observe interaction between family Fabaceaes phytochemistry and estrogen receptor?. Molecular docking analysis observed binding energy and binding location. This virtual screening analysis was done using PyRx, AutoDock Vina, PyMOL, Open Babel, and UCSF Chimera. Results: We obtained 471 Family Fabaceaes phytochemistry from database, only five compounds that have equal or lower binding energy compared with tamoxifen, that compound werebeta-amyrine (9.6 KJ/Mol), obovatin( 9.6 KJ/Mol), erythrabyssin II (9.6 KJ/Mol), Cajaflavanone (10.2 KJ/Mol), and tomentosanol E (10.5 KJ/Mol). The visualization of binding location analysis showed that only cajaflavanone which have relatively similar binding site location with tamoxifen. Conclusions: Cajaflavanone have a similar characteristic with tamoxifen, and have a potency to be used as partial antagonist of estrogen receptor alpha in breast cancer based molecular docking analysis. However, In vitro and In vivo researchneeded to determine the effectiveness. Keywords: Breast Cancer, Molecular Docking, Fabacea, Tamoxifen, Estrogen Receptor ?

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