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All Journal INDONESIAN JOURNAL OF PHARMACY JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR)

Fadlina Chany Saputri

UNIVERSITAS INDONESIA

Author-ID : 3685220

Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Articles

Synthesis and Preliminary In Vitro Anti-inflammatory Evaluation of Mannich Bases Derivatives of 4’-Methoxy-substituted of Asymmetrical Cyclovalone Analogs Rahmawati, Nur; Hariyanti, Hariyanti; Saputri, Fadlina Chany; Hayun, Hayun
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp35

Two of Mannich bases derivatives of 4’-methoxy-substituted of asymmetrical cyclovalone analog (ACA) (2a and 2b) were synthesized. The synthesized compounds and the other two Mannich bases derivatives of 4'-methoxy-substituted ACA (2c and 2d) were evaluated for their in-vitro anti-inflammatory activity preliminary by protein denaturation inhibition method using a final concentration of 1.57 μM. The study found that all the Mannich bases exhibited anti-inflammatory potential with inhibition ranging from 33.17- 42.47%. The activity of 2b (42,47%) and 2d (41.90%) was higher than that of diclofenac sodium (35.27%) and the parent compound 1 (38.16%). As a conclusion, 2b and 2d have a prospect as a potential candidate for an anti-inflammatory agent. Further study should be done using more specific methods.

Formulasi Emulgel yang Mengandung Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Uji Aktivitasnya terhadap Propionibacterium acnes secara In Vitro Tri Nofi Yani; Effionora Anwar; Fadlina Chany Saputri
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Binahong (Anredera cordifolia (Ten.) Steenis) leaves have been known to have antibacterial activity but the activity against Propionibacterium acnes as one of the bacteria that play a role in acne’s pathogenesis is still unknown. Binahong leaves ethanolic extract containing 1,28% of ursolic acid in this study were tested by in vitro against Propionibacterium acnes giving result minimum bactericidal concentration of 0,05%. Emulgel of binahong leaves ethanolic extract in this study had physical stability for 12 weeks. Inhibition zone of binahong leaves ethanolic extract emulgel is larger than clindamycin phosphate 1,2% against Propionibacterium acnes, which is in formula 1 (extract equivalen with MIC 0,05%) is 19,67±1,25 mm and formula 2 (extract equivalen double MIC 0,05%) is 20,67±0,47 mm, while inhibition zone of clindamycin phosphate 1,2% is 16,3±0,47 mm.

Formulasi Serum sebagai Penyembuh Luka Bakar Berbahan Baku Utama Serbuk Konsentrat Ikan Gabus (Channa striatus) SITI MARDIYANTI; EFFIONORA ANWAR; FADLINA CHANY SAPUTRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Ikan gabus (Channa striatus) diketahui dapat menyembuhkan luka karena mengandung kadar tinggi protein, asam amino esensial dan asam lemak yang berperan dalam proses penyembuhan luka. Tujuan dari penelitian ini adalah membuat serum sebagai penyembuh luka bakar yang mengandung serbuk konsentrat ikan gabus (Channa striatus) yang telah dibuat gelasi ionik dengan kitosan dan natrium tripolifosfat sebagai zat aktif. Serbuk konsentrat ikan gabus dengan kosentrasi 7,5% (formula 1), 10% (formula 2) dan 12,5% (formula 3). Selanjutnya dibuat menjadi serum dengan menggunakan kolagen dan gelatin sebagai bahan pengental. Sediaan serum yang dihasilkan dikarakterisasi in vitro dan dievaluasi secara in vivo penyembuhan luka bakar derajat dua (deep partial thickness) pada kelinci. Suspensi dan serum yang dihasilkan dikarakterisasi secara fisik maupun kimia. Hasil pengukuran suspensi formula 1, 2 dan 3 adalah sebagai berikut: ukuran partikel berturut–turut 42,67-204,23 nm, 70,81-257,11 nm, 128,86-323,68 nm; nilai potensial zeta (+)16,9 mV, (+)18,3 mV, (+)8,4 mV; ketiga formula memiliki partikel berbentuk sferis. Dari hasil uji in vivo dan analisa histologi sediaan serum serbuk konsentrat ikan gabus-kitosan tripolifosfat dapat digunakan sebagai penyembuh luka bakar derajat dua dalam.

Pengaruh Metode Ekstraksi Terhadap Kandungan Senyawa Polifenol dan Aktivitas Antioksidan pada Rubus fraxinifolius Yesi Desmiaty; Berna Elya; Fadlina Chany Saputri; Iis Irawatty Dewi; Muhammad Hanafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Rubus fraxinifolius can be founded in the mountainous regions of West Java. Previous studies have shown that this plant has potent antioxidant activity. The content of polyphenol compounds in this species contributes substantially to antioxidant activity, and the extraction method will affect the content of the compound. In this study an evaluation of the extraction method effect on leaves, young fruits and stems of R. fraxinifolius on the content of polyphenols and their antioxidant activity, have been done. Method: The leaves, fruits, and stems of R. fraxinifolius were extracted by maceration, reflux, and soxhlet using methanol as a solvent. Each extract was determined the total polyphenol content using Folin-Ciocalteu reagent and antioxidant activity test using DPPH reduction method. Result: The highest extract yield was R. fraxinifolius leaf reflux extract (30.20%). The highest total polyphenol content was given by the Soxhlet extract of leaf R. fraxinifolius (48.79 mg GAE / g extract). The highest antioxidant activity was leaf Soxhlet extract of R. fraxinifolius (98.29% at 100 ppm). Conclusion: From this study it was shown that the methanol extract of R. fraxinifolius leaves extracted by Soxhlet gave the highest polyphenol content and antioxidant activity.

Pengembangan Metode Induksi Tukak Lambung Saputri, Fadlina Chany; Sari, Santi Purna; Munim, Abdul
Majalah Ilmu Kefarmasian Vol. 5, No. 2
Publisher : UI Scholars Hub

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Scientific evaluation on pharmacological activity of medicinal herbs required repro-ducible and valid method-induced ulcer models in animal. In this study, the method of antiulcerogenic effect was investigated using several inducers. The male white Sprague-Dawley rats divided into five groups which were orally administrated water, indomethacin (48 mg/kg bw), aspirin-HCl (150 mg/kg bw), 96% ethanol (1 ml/200 g bw), and 80% ethanol (1 ml/200 g bw), respectively. The result of this study showed that the group was induced with 80% ethanol demonstrated the highest ulcer index. Histological examination of the stomach showed abnormality of mucosa cells on the aspirin-HCl, 96% ethanol, and 80% ethanol-induced gastric ulcer model in rats.

Uji Aktivitas Anti-Inflamasi Minyak Atsiri Daun Kemangi (Ocimum americanum L.) pada Tikus Putih Jantan yang Diinduksi Karagenan Saputri, Fadlina Chany; Zahara, Rita
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Kemangi (Ocimum americanum L.) is an aromatic plant that contains citral and known as anti-inflammatory agents. The aim of this study was to determine the anti-inflammatory activity of the essential oil kemangi leaves on carrageenan-induced rat. The male rats were divided into six groups, each consisting of four rats. Group I as negative control was given 0.5% CMC solution, group II as positive control was given diclofenac sodium, group III was given sitral, groups IV, V and VI were given 40 mg/200 g BW, 80 mg/200 g BW, and 160 mg/200 g BW essential oil of Ocimum americanum L., emulsified in 0.5% CMC solution. After 30 minutes of test substance administration, left paw of rats injected by 0.2 mL of carrageenan to induce edema. Edema volume was measured using pletismometer every hour for six hours. The result showed that at dose 160 mg/200 g BW gives the best effect in inhibited the inflamation response 44,83%. There was significant difference (p < 0.05) at dose 160 mg/200 g BB to negative control. From this study can be concluded that essential oil kemangi leaves has anti-inflammatory activity.

Pengaruh Pemberian Minyak Atsiri Daun Kemangi (Ocimum americanum L.) Terhadap ~ Motilitas Usus Mencit Putih Jantan Sriyani, Dewi; Saputri, Fadlina Chany
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Kemangi (Ocimum americanum L.) is a well known plant that contains essential oils with citral as a major compound. Citral is reported to have beneficial effect on intestinal motility. In the present study, we investigated the effect of essential oil of kemangi leaves (Ocimum americanum L.) on male DDY mices intestinal motility. Thirty mices were divided into six groups and each group was pretreated with 0,2 ml of 0,5% CMC (negative control), 1 mg/kg BW of atropine sulfate (positive control), 5 mg/kg BW of citral (comparative control), and three dose variation of volatile oil of kemangi leaves (25 mg/kg BW; 50 mg/kg BW; 100 mg/kg BW) orally. All mices were given charcoal meal suspension 0,2 ml orally, and the animals were sacrificed. The percentage ratio and inhibition were analysed by measure the intestinal transit of charcoal. The results showed that the essential oil of kemangi leaves dose 100 mg/kg BW significantly (p < 0.05) reduced intestinal transit in mice with the percentage ihibition value of 59,79%. This value is not significant different (p > 0.05) compared with citral and atropine sulfate. It is concluded that the essential oil of kemangi leaves has potential effect as antispasmodic agent.

Memory Loss induced by Aspartame in Albino Rats: Study on neurobehavioral changes Suswidiantoro, Vicko; Saputri, Fadlina Chany; Mun'im, Abdul
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 2: June 2021
Publisher : Universitas Aisyah Pringsewu

Objective: Aspartame (ASP) consumption in various food and beverage products has generated a lot of controversy on safety. Many reports, ASP caused deterioration of health condition likes diabetes, psychiatric disorders, memory loss, etc. This study aimed to investigate the optimization duration of ASP to induce memory loss in Sprague Dawley rats. Methods: The ASP was administered 40 mg/kg BW orally for 28 days in rats. Analysis of memory loss by neurobehavioural changes including latency time, length of track, per cent time and frequency target quadrant using Morris Water Maze (MWM) at day 14, 21, 28, and 24 hours after the last treatment. Results: The administration of ASP showed the time-dependent changes for each indicator of neurobehavioural. The results demonstrated during 28 days of induction showed a significant decrease in latency time, length of track, per cent time and frequency target quadrant. Conclusion: From the results, it can be concluded administration of ASP during 28 days induce neurobehavioural changes related to memory loss in rats. Abstrak: Objektif: Penggunaan aspartame (ASP) sebagai pemanis buatan yang banyak terdapat pada makanan, dan minuman menimbulkan berbagai kontroversi dalam hal keamanan. Berbagai data menunjukkan ASP dapat menyebabkan gangguan kesehatan seperti diabetes, gangguan psikiatrik, penurunan fungsi memori, dll. Penelitian ini bertujuan untuk menentukan waktu durasi penggunaan ASP yang dapat menyebabkan gangguan fungsi memori pada tikus Sprague Dawley. Metode:ASP diberikan secara oral pada tikus dengan dosis 40 mg/kg BB selama 28 hari. Analisis terhadap fungsi memori dilakukan dengan adanya perubahan perilaku pada hewan, meliputi waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran menggunakan Morris Water Maze (MWM) setelah 24 jam setelah pemberian pada hari ke 14,21, 28. Hasil: Pemberian ASP menunjukkan adanya perbedaan waktu pada setiap indicator perilaku. Pemberian selama 28 hari menujukkan adanya perbedaan signifikan pada penurunan waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran. Kesimpulan: Berdasarkan hasil, pemberian ASP selama 28 hari dapat menyebabkan adanya perubahan perilaku yang berkaitan dengan fungsi memori pada tikus.

Co-Authors Abdul Mun'ím Abdul Munim Berna Elya Dewi Sriyani Dewi Sriyani, Dewi Effionora Anwar Effionora Anwar Hayun, Hayun Iis Irawatty Dewi Muhammad Hanafi Mun'im, Abdul Nur Rahmawati Rita Zahara Rita Zahara, Rita Santi Purna Sari Santi Purna Sari SITI MARDIYANTI Suswidiantoro, Vicko Tri Nofi Yani Yesi Desmiaty, Yesi

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