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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Search results for , issue " Vol 7, No 1 (2018): edisi Maret 2018" : 10 Documents clear
The Relationship Anxiety With Degree of Insomnia In The Elderly Sincihu, Yudhiakuari; Daeng, B. Handoko; Yola, Priska
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Anxiety is a mental disorder common in elderly people. In the process of becoming elderly, feelings of anxiety arise as a normal response to situations that accompany development, change, new experiences and find meaning in life. Anxious looks from physiological symptoms such as shaking, sweating, heart work increases and psychological symptoms such as panic, tension, confusion, unable to concentrate. This condition will inhibit the elderlys bio-psycho-social condition in living the rest of his life. One effect is seen from their sleep problems. This is observational research with cross-sectional approach. Samples were taken by consecutive sampling technique. 43 elderly who met the exclusion criteria. Research location at Posyandu Lansia Mojo, Surabaya. Data collection using Hamilton Rating Scale for Anxiety and Insomnia Severity Index questionnaires. the results of the study described 41.9% of subjects with anxiety disorders and 67.4% of subjects had insomnia disorders. The cross-tabulation results showed 48% of subjects without anxiety can occur insomnia disorders and only mild anxiety alone can cause insomnia in 100% of subjects. Rank Spearman Test shows a very strong relationship between anxiety with the incidence of insomnia in the elderly (Sig .000; coefficient correlation .535).
The Role Of Zinc Sulphate And Omega 3 On The Improvement Of Weight And Speed Conversion Conversion On Tuberculosis Parent Patients At Surabaya Park Hospital, 2015 Durry, Fara Disa; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, can affect almost all organs of the body with the most locations in the lungs. Immunity and high nutrients such as vitamin C, zinc and other antioxidants have shown good effects for infections, including tuberculosis. One effort to help accelerate sputum conversion of people with pulmonary tuberculosis is by supplementation of Zinc Sulphate and Omega 3.Objective: Analyze the role of Zinc Sulphate and Omega 3 on sputum conversion acceleration in patients with pulmonary tuberculosis at Surabaya Paru Hospital 2015.Method: This research use Randomized Pre Post Test Post Control Group Design design. In patients with pulmonary tuberculosis with Zinc Sulphate and Omega 3 in the treatment and placebo group in the control group. A sample of 20 patients consisting of 10 treatment patients and 10 control patients. Statistical test using paired T-Test, Friedman test and Mann whitney.Results: Friedman test showed that in the treatment group showed significant difference in the number of BTA between before and after supplementation (p=0,001), while in the control group significance of 0.141. Mann-Whitney test  showed no significant difference in the amount of reduction of BTA between the treatment group and the control group (p = 0.080). This means that statistically does not show any significant difference.Conclusions: Zinc Sulphate and Omega 3 play a role in accelerating sputum smear conversion of respondents. The results of smear test in pulmonary TB patients with Zinc Sulphate and Omega 3 supplementation showed positive results
PENGARUH PEMBERIAN ANTIBODI POLIKLONAL PMSG (Pregnant Mare Serum Gonadotropin) (Abpo PMSG) YANG BERASAL DARI KELINCI (Oryctolagus cuniculus) JANTAN TERHADAP JUMLAH FETUS MENCIT (Mus musculus) rahmawati, indra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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The purpose of this study was to evaluate the potencial influence local product Abpo PMSG treatment on mice foetus number. Methode used for this research was by injecting 0,1 ml Abpo PMSG on superovulated mice with PMSG and hCG. There were six treatment in this research. Control group was group  of mice that only superovulated. P1 was given PMSG and Abpo PMSG together. P2 was group of mice that wich Abpo given 1 hour after PMSG, P3 given Abpo PMSG when they were estrous. P4 given Abpo PMSG 1 hour before hCG, and P5 given Abpo PMSG 1 hour after hCG. The result showed that the most foetus number resulted from P3. The least foetus number was from control group. Foetus number of P1, P2, P4 and P5 was showed no significant difference with P3 group ( P > 0,05).Key words : PMSG, Abpo PMSG, foetus number
THE EFFECT OF BLACK CUMIN SEED (Nigella Sativa L.) EXTRACT TO ALLOXAN INDUCES PANCREATIC TISSUE CATALASE ENZYME ACTIVITY OF MALE WISTAR RATS (Rattus norvegicus) achmad, qonita; Dikman, Irmawati; Prabowo, Sulistiana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Alloxan causes the formation of reactive oxygen through the reduction process of alloxan (dialuric acid) in the β cells of pancreas. Free radicals cause damage  and decrease catalase enzyme activity. Black cumin seeds extract which contain carotenoids, thymoquinone, carvacrol, 4-terpineol, t-anethole, and tert-butylhydroquinone (TBHQ) has antioxidant activity that is expected to inhibit reactive oxygen species (ROS) that is expected to increase pancreatic catalase activity. This study used 24 male Wistar rats, divided into 3 groups:1)group of rats fed with standard food, 2)group of rats induced by alloxan 125mg/kg /BB intraperitoneally on day 1, 3)groups of rats induced by alloxan 125mg/kg/BB intraperitoneally on day 1 and were given by black cumin seed extract 2500mg/kg/BB orally on day 4 until 17. On the 18th day of all rats were sacrificed and pancreatic tissue catalase activity were measured by the spectrophotometric method. The results of One-Way ANOVA showed significant difference (p=0.003) pancreatic tissue catalase activity of groups of rats fed with standard food (1696,96U/g±414,10U/g) compared with group of rats induced by alloxan (1287,58U/g±88,45U/g). There was significant difference (p=0.001) of pancreatic tissue catalase activity of groups of rats induced by alloxan (1287,58U/g±88,45U/g) with a group of rats induced by alloxan and given with black cumin seed extract (1764,83U/g±199,69U/g). The conclusion of this study showed that the administration of alloxan significantly decreased pancreatic tissue catalase activity of rat and black cumin seed extract significantly increased catalase activity because cumin extract has antioxidant effects.
TINGKAT ASFIKSIA NEONATORUM BERDASARKAN LAMANYA KETUBAN PECAH DINI PADA PERSALINAN ATERM sari, andini kartika; Sincihu, Yudhiakuari; Ruddy, B. Triagung
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Angka kematian neonatus merupakan salah satu indikator untuk menilai kesehatan di masyarakat. Berdasarkan WHO, penyebab utama kematian neonatus diantaranya adalah prematuritas, asfiksia neonatorum dan sepsis neonatorum. Faktor penyebab terjadinya asfiksia neonatorum salah satunya KPD. Tujuan penelitian ini untuk mengetahui apakah lamanya KPD pada persalinan aterm berhubungan terhadap tingkat asfiksia bayi baru lahir. Penelitian ini bersifat observasional analitik menggunakan data sekunder dengan pendekatan retrospektif, rancangan cross-sectional. Teknik pengambilan sampel menggunakan purposive sampling. Data diambil selama 18 bulan yaitu periode 1 Januari 2016 hingga 30 Juni 2017. Populasi pada penelitian ini adalah 1594 ibu yang melahirkan dan 1619 bayi yang dilahirkan. Data ibu bersalin dengan riwayat KPD terdapat sebanyak 168 dan 80 ibu dan bayinya yang memenuhi kriteria. Data dianalisis menggunakan uji korelasi Spearman’s rho. Hasil penelitian menunjukkan terdapat hubungan antara lamanya KPD dengan tingkat asfiksia nonatorum, dengan nilai signifikansi p = 0,029 (p < 0,050) dan nilai koefisien korelasi (C) - 0,244 yang termasuk koefisien korelasi rendah hubungan terbalik. Interpretasi hubungan terbalik menunjukkan bahwa semakin meningkat lama KPD maka nilai APGAR semakin menurun atau tingkat asfiksia semakin berat.
Pemanfaatan Seduhan Daun Ashitaba dengan Simvastatin dalam Menurunkan Kadar LDL Tikus Putih Jantan Strain Wistar Ernawati, Ernawati; Widjaja, Theresia Ratnasari
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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High levels of blood cholesterol or hypercholesterolemia is an important risk factor for a cardiovascular disease. In order to overcome this problem, giving statins drug such as simvastatin is an intervention that is often applied. Besides using this drug, it can also be accompanied by consuming herbal plants which is Ashitaba leaves (Angelica keiskei). It contains Chalcones which demonstrates anti tumour property and also antioxidant activity that can lower cholesterol levels, especially LDL in the blood. This study aimed to investigate the effect of Ashitaba leaves (Angelica keiskei) steeping administration in assisting simvastatin drugs to decrease the levels of Low Density Lipoprotein (LDL) in the blood serum of male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. The population for this study was male white rats Strain wistar (Rattus Norvegicus) with samples taken in this study were 33 white rats. Data analysis for this study is using One Way Anova test.The result showed that supplementation of simvastatin treatment using steeping Ashitaba leaves might slightly reduce LDL level among male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. However, the result demonstrated not significant different.   To assist simvastatin drugs in lowering LDL levels in male white rats Strain wistar (Rattus Norvegicus) which is made to be hypercholesterolemia can lower LDL levels slightly but not significantly (p-value = 0,177) which is >a (0,05).
Pharmacogenomics Statins: Biomarkers for Clinical Prediction Suprapti, Herni
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Statins are the most widely prescribed drug for hyperlipidemic therapy and for the prevention of Cardiovascular disease. But although statins are very effective for the prevention of atherosclerosis, there are still patients with CVD. In this case, it is thought to be the influence of genetic factors. There is a static gene link to statin dose required for therapy, but there are still no relevant pharmacogenomic tests for statin therapy guidelines. This article describes basic pharmacogenomic terminology, genes (CETP, HMGCR, SLCO1B1, ABCB1, and CYP3A4 / 5), and progression of statin pharmacogenomic biomarkers for predicted therapeutic outcomes.
Aktivitas Ekstrak Kulit Mahkota Dewa (Phaleria macrocarpa) Sebagai Teraupetik Diabetes Mellitus Terhadap Glukosa Darah, Leukosit Dan Hemoglobin Pada Tikus Yang Diinduksi Aloksan Candrarisna, Miranti; Kurnianto, Ady
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
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Tujuan Penelitian ini adalah untuk mengetahui efektifitas ekstrak kulit mahkota dewa sebagai terapeutikadiabetes mellitus tipe 1 terhadap profil leukosit dan hemoglobin pada tikus yang diinduksi aloksan. jenis penelitian ini eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL). Sampel Hewan yang digunakan adalah tikus jantan umur 5-6 minggu sebanyak 24 ekor. Kelompok tikus dibagi menjadi tiga kelompok, yaitu kelompok kontrol negatif (diinduksi aloksan 0,2 ml/ip tanpa diobati/P0), kontrol positif: diinduksi aloksan 0,2 ml/ip dan diobati syrupus ekstrak kulit buah mahkota dewa 50% diberikan 1 kali sehari (P1), diinduksi aloksan 0,2 ml/ip dan diobati syrupus ekstrak kulit buah mahkota dewa 50% sebanyak 2 kali sehari (P2). Semua tikus diberikan perlakuan pengobatan kulit buah mahkota dewa 50% selama 10 hari. Pengamatan dilakukan pada hari ke-0, 5, 10. Parameter pengamatan adalah kandungan senyawa aktif tanaman, kadar glukosa darah, profil leukosit (neutrofil, basofil dan eusinofil) dan hemoglobin. Semua data yang diperoleh, dilakukan analisis statistik dengan menggunakan ANOVA dengan taraf kepercayaan 95% (=0,05). Hasil statistik menunjukkan bahwa pada tikus yang diobati syrupus kulit buah mahkota dewa 50% 2 kali sehari (P2) menunjukan hasil yang paling baik daripada kelompok P0 dan P1.Analisis statistik menunjukkan Fhitung > F tabel berarti terdapat perbedaan yang signifikan antara kelompok P2 dengan P0 dan P1 terhadap penurunan glukosa, peningkatan profil leukosit, dan nilai hemoglobin yang normal. Hasil  penelitian ini menunjukan bahwa aktifitas  syrupus kulit buah mahkota dewa50% yang diberikan dua kali sehari paling efektif digunakan sebagai terapeutika diabetes mellitus tipe-1 pada tikus putih yang diinduksi aloksan.
Pengaruh Pemberian Ekstrak Alga Merah (gracilaria verrucosa) terhadap Aktivitas SGPT pada Tikus Putih (rattus norvegicus) Jantan Galur Wistar yang Diinduksi Parasetamol Dosis Tinggi Fikri, Akbar Maharudin; Tehupuring, Sihning EJ
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
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Background: Administration of high dose paracetamol may increase the metabolic pathways that produce N-acetyl-p-benzoquinonimin (NAPQI). NAPQI is a reactive substance, resulting liver tissue damage and increase SGPT activity. Red algae extract contains flavonoids that act as antioxidants.Objectives: This research aimed to determine the effect of red algae (Gracilaria verrucosa) extract to the activity of serum glutamic pyruvic transaminase (SGPT) in male Wistar rats (Rattus norvegicus) induced by high dose paracetamol.Methodology: This research used 24 animal of Male Wistar rats. These rats were divided into 3 groups: 1) group of rats fed with standard food; 2) group of rats given paracetamol 1750 mg/kg on day 10; and 3) group of rats given red algae extract 200 mg/kg/day on day 1-11 and paracetamol 1750mg/kg on day 10. On day 11, all rats were sacrificed and SGPT activities were measured by spectrophotometry method.Result: Mann-Whitney test results showed significant difference (p = 0.021) between SGPT activity of group of rats fed with standard food (=81.95±10.103 U/L) and group of rats induced by high dose paracetamol (=97.06±11.19 U/L). Furthermore, there was significant difference (p = 0.016) between SGPT activity of group of rats induced by high dose paracetamol (=97.06±11.19 U/L) and group of rats induced by high doses of paracetamol and fed with red algae extract (=82.73±11.233 U/L).Conclusion: The conclusion of this research showed that high dose paracetamol significantly increased SGPT activity and red algae extract significantly decreased SGPT activity because it contains flavonoids that act as antioxidants.
Correlation of Tumor Marker Cancer Antigen (CA-125) against Hemoglobin, Leucocytes, and Platelet Lymphocyte Ratio in Ovarian Cancer Patients at RSUD ULIN Banjarmasin sabarudin, hermin
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
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CA-125 is the most commonly used tumor marker in ovarian cancer, its known as the "Gold Standard" for the diagnosis of ovarian cancer. CA-125 allegely related to the inflammatory mechanisms which associated with leukocytes and lymphocytes, as well as Lymphocyte Platelet Ratio. This study is to prove above hypothesis. The objective is to investigate CA-125 correlation as tumor marker of inflammatory hematology examination which consisting of Hemoglobin, leucocytes and PLR as indicator of inflammatory examination in ovarian cancer patient. The method is an observational analytic study with cross sectional retrospective descriptive. The sample is 42 patients medical record who are treated in Oncology Polyclinic RSUD ULIN in October 2014 - October 2017 period. Samples selected by time limitation method. Sampling technique using nonpropability method followed by purposive sampling method. After the data is taken and selected then processed into SPSS for normality test and continued by multiple linear regression test. The results showed that correlation analysis of CA-125 tumor marker on Hb, leukocyte and PLR levels was P = 858b; P value <0.05. The CA-125 relationship to Hb, leucocytes and PLR is a negative relationship (r Hb = -3,463, r leukocytes = -6,117, r PLR = -2.281), which means that more high the Hb, leukocyte and PLR value, conversely CA125 value become more low. The conclusions of this study is there no correlation of CA125 tumor marker against Hb, leucocytes and PLR in ovarian cancer patients. The results of this study indicate that the increasing of CA125 value is negative correlation because it is not followed by decreasing of Hb, increasing of leukocyte and PLR. 

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