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Milala, Alasen Sembiring
Fakultas Farmasi Universitas Surabaya
Health Professions Medicine & Pharmacology

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Karakteristik Fisik dan Displacement Value Supositoria Neomisin Sulfat berbasis PEG Boehe, Andrew Pierce; Milala, Alasen Sembiring; Pradana, Aditya Trias
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6516.26 KB)

Abstract

Physical characteristic and the Displacement Value of neomycin sulfate in suppository with various composition of PEG 400-4000 as it carrier has been studied. Displacement Value has been determined to adjust the weight of suppositories that varies due to the density difference among drug substance and its carriers. The method used in the determination of Displacement Value is the Moody method. Beside the displacement value, we have also evaluated the physical characteristic of suppository that has been produced, such as weight uniformity, hardness, macro and micro melting point and liquefaction ability. The results shows that all measurements meet the requirements and the Displacement Value of Neomycin sulfate obtained from Moody method, was 0.96.Keywords : Suppository, Displacement Value, Neomycin sulfate.
Karakteristik Fisik dan Displacement Value Supositoria Neomisin Sulfat berbasis PEG Milala, Alasen Sembiring; Pradana, Aditya Trias; Boehe, Andrew Pierce
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6516.26 KB) | DOI: 10.35617/jfi.v6i3.158

Abstract

Physical characteristic and the Displacement Value of neomycin sulfate in suppository with various composition of PEG 400-4000 as it carrier has been studied. Displacement Value has been determined to adjust the weight of suppositories that varies due to the density difference among drug substance and its carriers. The method used in the determination of Displacement Value is the Moody method. Beside the displacement value, we have also evaluated the physical characteristic of suppository that has been produced, such as weight uniformity, hardness, macro and micro melting point and liquefaction ability. The results shows that all measurements meet the requirements and the Displacement Value of Neomycin sulfate obtained from Moody method, was 0.96.Keywords : Suppository, Displacement Value, Neomycin sulfate.
Co-Authors Boehe, Andrew Pierce Boehe, Andrew Pierce Pradana, Aditya Trias Pradana, Aditya Trias