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All Journal Indonesian Journal of Cardiology Narra J The Journal of Society Medicine (JSOCMED)
Hasan, Harris
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Association of Triglyceride/High Density Lipoprotein Cholesterol Ratio and Coronary Lesion Severity in Acute Myocardial Infarction Patients at Adam Malik Hospital, Medan Sinaga, Akbar; Hasan, Refli; Reynaldo, Abdul Halim; Hasan, Harris; Akbar, Nizam Zikri; Andra, Cut Aryfa
Journal of Society Medicine Vol. 2 No. 3 (2023): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i3.30

Abstract

Introduction: Coronary heart disease is the leading cause of worldwide death. A number of markers have been identified in terms of the atherogenic potential of the lipid profile.The TG/HDL-C ratio is an easy and economical non-invasive examination method as a predictor of coronary heart disease severity. The aim of this study is to assess the relationship of the TG/HDL ratio with the severity of coronary lesions. Method: This cross-sectional study included 53 acute myocardial infarction patients undergoing coronary angiography. Exclusion criteria include (1)AMI patients receiving fibrinolytic therapy, (2) Patients who have routinely consumed lipid lowering drug for 6 weeks,(3) Incomplete coronary angiography and medical records. The TG/HDL ratio is the result of dividing the triglyceride value by HDL. The TG/HDL ratio was divided into 2 groups, namely the TG/HDL ratio <4 group and the TG/HDL ratio >4 group. The severity of coronary lesions was described by the SYNTAX score, which was divided into two: the low SYNTAX score group (≤22) and patients with a low SYNTAX score (≤22) and medium-high SYNTAX score (≥23). Bivariate analysis was performed to find the relationship between the TG/HDL ratio and the SYNTAX score. The value of p<0.05 was considered statistically significant. Results: From 53 patients, 26 patients (49.1%) had a SYNTAX score ≥ 23 and 27 patients (50.9%) had a SYNTAX score < 23. Patients with NSTEMI, DM risk factors, and obesity were higher in the SYNTAX score group ≥23. From the results of statistical analysis, there was a significant relationship between the TG/HDL ratio with coronary lesion severity (p = 0,004). Conclusion: Enhancement of TG/HDL ratio is correlated with coronary lesion severity in acute myocardial infarction patients using the SYNTAX score.
The Relationship Between Serum Apolipoprotein B Levels and Severity of Coronary Lesions Using The Syntax Score in Non-St Segment Elevation Acute Myocardial Infarction Patients at Haji Adam Malik General Hospital Medan Kesumawardani, Enggar Sari; Safri, Zainal; Hasan, Harris; Hasan, Refli; Andra, Cut Aryfa; Ardini, Tengku Winda
Journal of Society Medicine Vol. 2 No. 4 (2023): April
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i4.32

Abstract

Introduction: Acute coronary syndrome mainly occurs as a result of plaque rupture of atherosclerosis. Apolipoprotein B (apoB) is a large glycoprotein, playing a role in lipoprotein metabolism and human lipid transport reflecting the number of circulating atherogenic particles. The purpose of this study was to assess the relationship of serum apoB levels with coronary lesion severity. Method: This is a cross-sectional study involving patients who was diagnosed with Non-ST Elevation Myocardial Infarction (NSTEMI) who underwent coronary angiography in November 2021 to July 2022. The NSTEMI criteria follow the Universal Definition of Myocardial Infarction and coronary severity is assessed using a SYNTAX score. Bivariate analysis was conducted looking for the relationship between apoB with SYNTAX scores with p<0.05 considered statistically significant. Results: The subjects of the study is 70 people, dominated by male 50 patients (71.4%). The median age of the subjects was 56 (38-77) years. Median levels of apoB was 107 (32-150) mg/dL. The average SYNTAX score was 25.66 ± 10.83. Using the Pearson correlation test, it was shown that there is a significant correlation between apoB and coronary lesion severity obtained r=0.442 (p<0.001). Conclusion: There is a significant correlation between apoB and coronary lesion severity using SYNTAX scores in NSTEMI patients.
The Relationship Between Aerobic Physical Exercise to Functional Capacity in Heart Failure Patients at Haji Adam Malik General Hospital Medan Khairunnisah, Dina; Hasan, Harris; Reynaldo, Abdul Halim; Haykal, Teuku Bob; Sarastri, Yuke
Journal of Society Medicine Vol. 2 No. 9 (2023): September
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i9.87

Abstract

Introduction: The prevalence of heart failure is known to increase day by day, as well as the incidence of rehospitalization and death. One way that can be done is to optimize health status and perform cardiac rehabilitation. Aerobic exercise is recommended for patients with heart failure. Aerobic exercise has been shown to increase functional capacity in patient with heart failure. The aim of this study is to assess the relationship between aerobic exercise with functional capacity improvement in patient with heart failure in Haji Adam Malik General Hospital, Medan. Method: This study was conducted using prospective cohort method on 35 patients with heart failure in a cardiac rehabilitation program at Haji Adam Malik General Hospital, Medan. Functional capacity and 6-Minute Walk Test (6MWT) data were collected before and after aerobic exercise. Univariate and bivariate data analysis were performed using SPSS. Results: 35 samples were included in this study, with an average age of 54,57±1,28 years and dominated by male. The result showed an increase in distance after aerobic exercise program compared to the initial examination (373,6±133,64 vs 192,57±64,68) with p-value <0,001. There was an increase in functional capacity from 3,55±1,12 MET to 6,6±2,44 MET after aerobic exercise (P<0,001). Conclusion: There is a significant relationship between aerobic exercise and functional capacity improvement in patients with heart failure at Haji Adam Malik General Hospital, Medan.
The Relationship between LDL/ HDL Ratio and Coronary Lesion Severity Measured by Syntax Score in Patients with Non-Elevation Acute Myocardial Infarction at Hajj Adam Malik General Hospital, Medan Hashmi, T. Rifqi; Hasan, Harris; Lubis, Hilfan Ade Putra
Journal of Society Medicine Vol. 3 No. 5 (2024): May
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i5.146

Abstract

Introduction: Coronary artery disease (CAD), results from reduced myocardial perfusion leading to angina, myocardial infarction (MI), and/or heart failure. It accounts for one third to one half of cardiovascular cases. A higher SYNTAX score indicates a more complex condition and poorer prognosis in patients undergoing coronary revascularization especially with PCI. This study aims to determine how the LDL/HDL ratio relates to the complexity of coronary lesions (Syntax Score) in coronary heart disease based on characteristics. Methods: The type of this study was observational analytic retrospective with a cross sectional design. The study was conducted using secondary data through medical record data of patients diagnosed with NSTEMI. Results: The subjects were 60 people with an average age of  58,1±8,629. It was found that the mean value of the LDL/HDL ratio was 3,95±3,837, in patients with an LDL/HDL ratio ≥ 2.517 it was found that there were 40 sample(66.7%) of whom had a lesion severity level of Syntax score ≥23 ,27 samples (45%), and in patients with an LDL/HDL ratio < 2.517, 20 samples (33.3%) were found to have a lesion severity level of Syntax score ≥ 23 with 4 samples (6.7%). Conclusion: There is a relationship between the LDL/HDL ratio and the severity of CAD based on the Syntax score with LDL/HDL ratio values being higher in patients with moderate-severe CAD than in patients with mild CAD.
Validasi Skor PEACH sebagai Prediktor Mortalitas Selama Rawatan Paska Operasi Penyakit Jantung Bawaan Pada Dewasa di Rumah Sakit Umum Pusat Haji Adam Malik Medan Zebua, Juang Idaman; Nasution, Ali Nafiah; Ketaren, Andre Pasha; Hasan, Harris; Akbar, Nizam Zikri
Jurnal Kardiologi Indonesia Vol 44 No 2 (2023): Indonesian Journal of Cardiology: April - June 2023
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1546

Abstract

Introduction: Congenital heart disease (CHD) is an abnormality in the structure and function of the heart that is acquired while still intrauterine where the incidence of CHD worldwide is estimated at around 8 cases per 1,000 live births. Even though the development of the medical science is currently advanced, there are still CHD patients who are lately diagnosed and found when the patient is an adult so it requires surgical interventions. The PEACH score is a score that can predict postoperative in-hospital mortality in adults CHD patients. This study aims to validate the PEACH score. Methods: This is a retrospective cohort study of 52 adult patients with CHD who underwent surgery at Haji Adam Malik General Hospital from January 2019 to April 2023. Validation was analyzed using a calibration and discrimination test to the PEACH score in predicting postoperative in-hospital mortality. Result: The incidence of in-hospital mortality was 8 (15.4%) patients. There is a relationship between the PEACH score group and the incidence of mortality (p=0.006). The results of the calibration test using the Hosmer and Lameshow analysis and the discrimination test using the Receiver Operating Characteristic analysis showed good validation (p=0.85; AUC=0.83). Conclusion: The PEACH score is valid for predicting postoperative in-hospital mortality in adult congenital heart disease at Haji Adam Malik General Hospital.
Relationship of left ventricular diastolic dysfunction with quality of life in heart failure patients with reduced ejection fraction (HFrEF) Khaidirman, Sophia K.; Hasan, Harris; Andra, Cut A.; Lubis, Hilfan AP.; Dangana, Amos; Haykal, T. Bob
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.707

Abstract

Heart failure is a complex clinical manifestation due to diastolic dysfunction and systolic dysfunction of the left ventricle (LV). Diastolic dysfunction of the LV plays an important role in worsening the quality of life (QoL) in heart failure patients. The aim of this study was to assess the relationship between the severity or grade of LV diastolic dysfunction and QoL in heart failure with reduced ejection fraction (HFrEF) patients. A retrospective cohort study was conducted at the Cardiac Center of H. Adam Malik Hospital, Medan, Indonesia, from January 2022 to December 2022. This study included inpatients and outpatients aged above 18 years who were diagnosed with HFrEF, identified by echocardiography with an ejection fraction of ≤40%. Echocardiography was performed to evaluate left ventricular diastolic dysfunction, and QoL was assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) 6–12 months after the severity of LV diastolic dysfunction was confirmed. The MLHFQ was classified into good and poor QoL. The severity of LV diastolic function was measured using the E/A ratio, mean E/e' ratio, tricuspid regurgitation velocity (TR Vmax), and left atrial volume index (LAVI), and was classified into grades I, II, and III. The relationships between the severity of diastolic dysfunction and other factors with QoL were measured using Chi-squared, Fisher's exact test, or Mann-Whitney test, as appropriate. A total of 96 patients were included in the study, of which 56 (58.3%) patients had grade I, 12 (12.5%) had grade II, and 28 (29.2%) patients had grade III of LV diastolic dysfunction. There were 77 (80.2%) and 19 (19.8%) patients with good and poor QoL, respectively. This study revealed a significant relationship between the severity of LV diastolic dysfunction and QoL in HFrEF patients with p=0.040. In conclusion, the degree of LV diastolic dysfunction is related to the QoL of HFrEF patients and therefore better comprehensive management strategies should be considered in HFrEF cases to address the impact of LV diastolic dysfunction on QoL.
Co-Authors Akbar, Nizam Zikri Andra, Cut A. Andra, Cut Aryfa Ardini, Tengku Winda Dangana, Amos Hasan, Refli Hashmi, T. Rifqi Haykal, T. Bob Haykal, Teuku Bob Kesumawardani, Enggar Sari Ketaren, Andre Pasha Khaidirman, Sophia K. Khairunnisah, Dina Lubis, Hilfan Ade Putra Lubis, Hilfan AP. Nasution, Ali Nafiah Reynaldo, Abdul Halim Safri, Zainal Sarastri, Yuke Sinaga, Akbar Zebua, Juang Idaman