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All Journal JURNAL WIDYA MEDIKA Health and Medical Journal Jurnal MedScientiae Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Kartika, Ronald Winardi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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ASSOCIATION BETWEEN HEART RATE VARIABILITY AND BLOOD PRESSURE IN ELDERLY WORKER Kartika, Ronald Winardi; Susanti, Yosephin Sri; Winata, Susanti Dewi
JURNAL WIDYA MEDIKA Vol 10, No 1 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i1.3765

Abstract

Life expectancy increases along with improving health. A good healthy life as an impact that there are still many workers in old age who are still needed. The effect of age and work environment will affect the normal range of time-domain heart rate variability (HRV) in older worker. Heart rate variability test might detect autonomic nervous system influenced by blood pressure level, stress, and working environment. A low HRV value is considered an independent marker of risk of death. However, age-related decline in HRV may limit its predictive value, especially in older workers. It was found that the decrease in HRV decreased with age and length of service. The elevation of HRV at specific wavelengths was correlated with the blood pressure values of hypertension patients; however, in the uncontrolled hypertensive group, the values of SDNN, SDANN, ASDNN, VLF, LF (indicating sympathovagal balance), and HF were significantly lower.
Evaluasi Mikrovaskuler dengan Near Infrared Spectroscopy pada Pasien Kaki Diabetes Kartika, Ronald Winardi; Timotius, Kris Herawan
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3074

Abstract

Peripheral Arterial Disease (PAP) requires good evaluation to reduce amputation rate. The aim of this study is to assess non-invasive detection methods in evaluating microvascular conditions in PAP. The potential use of Near Infrared Spectroscopy (NIRS) in identifying disorders in patients with PAP, either with or without DM, was also assessed. A systematic literature search was conducted through PUBMED until October 2023. Based on the literature review, it can be concluded that the use of NIRS in evaluating microvascular status in PAP is a non-invasive testing method that has expanded its role. Evaluation with NIRS provides metrics such as recovery time, deoxygenation, oxygen consumption (VO2), tissue oxygen saturation (StO2), total haemoglobin (HbT), and oxyhemoglobin area under the curve (O2 HbAUC). NIRS also has the potential to assist multidisciplinary teams in treating high-risk patients, especially in diabetic patients whose symptoms are compensated by peripheral neuropathy. This study shows that NIRS can be used as a useful tool in evaluating microvascular status in PAP, by providing important information that can be used to optimise patient care and prevent more serious complications. It is concluded that NIRS can be used as a tool to evaluate the effectiveness of treatment and prevent worsening of the condition of patients with PAP in diabetic foot.
Potensi Sekretom Mesenchymal Stem Cell pada Terapi Regeratif Penyakit Paru Fibrosis Kartika, Ronald Winardi; Timotius, Kris Herawan
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3142

Abstract

Fibrosis lung diseases such as chronic obstructive pulmonary disease, acute lung injury and post-Covid 19 fibrosis lung disease are considered as major health problems in the last decade. Cellular therapy with Mesenchymal Stem Cells (MSC) offers a novel therapeutic approach for fibrosis lung disease associated with anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties. Such therapeutic effects may be attributed to the MSC-secretome, which is made of free soluble proteins and extracellular vesicles (EVs). This review summarises some recent literature findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, demonstrating the biologically active substances contained in the MSC-secretome and its mechanisms involved in tissue regeneration. A perspective view is given on the secretome being a high-quality, safe and effective medicinal product,  
Curcumin as Adjuvant Therapy in Mild-Moderate Covid 19 Kartika, Ronald Winardi; Tendean, Marcel; Yong, Bernard Jonathan Christian; Sartika, Katarina Dewi; Suradji, Eka Widrian; Hasan, Irsan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 6 No. - (2022): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v6i-.127

Abstract

Background: Coronavirus (Covid-19) has spread rapidly to more than 200 countries, including Indonesia. Adjuvant therapy of Vitamin C, D, Zinc has become beneficial for Covid-19 treatment to improve the immune system, while Curcumin is still not standard therapy. Curcumin can stimulate specific immune cells and can reduce oxidative stress. There is currently no scientific evidence showing that the addition of Curcumin can protect COVID-19, especially as an anti-inflammation and anticoagulant effect. Methods: This cross-sectional study was conducted at Ukrida Hospital from January -June 2021. The inclusion criteria are Mild-Moderate Covid-19 use on Curcumin and Supplement therapy ( Vitamin C, Vitamin D, and zinc). Data analyses with SPSS v.20 use Anova test and Kruskall Walis test. This study had been approved by The Institutional Board of the Faculty of Medicine Universitas Krida Wacana, Indonesia (No. 1053/SLKE-IM/UKKW/FKIK/KE/II/2021). Research Objectives: To see the effect of Curcumin as an additional therapy from Covid-19 by clinical and laboratory inflammation indicators of the usefulness of Curcumin are such as ratio neutrophil/lymphocyte, ratio platelet/lymphocyte, erythrocyte sedimentation rate (ESR), C-Reactive Protein ( CRP), and D Dimer. Results: There were 246 cases, with 62.6% male and 56.5% female taking Curcumin. Curcumin has a good effect in reducing inflammation and coagulation in mild-moderate Covid-19. Patient who got Curcumin or without Curcumin as additional supplement therapy shows patient that got Curcumin has decreased inflammatory markers N/L ratio (p = 0.041), P/L ratio (p = 0.040), ESR (p = 0.013 ), and CRP ( p= 0.045). Curcumin also has an anticoagulant effect that shows a decrease of D-Dimer ( p= 0.020). Conclusion: Curcumin is beneficial in mild-moderate Covid-19 as an anti-inflammatory and anticoagulant.
Penggunaan Ukrida ChatBot pada Pemeriksaan Kesehatan Karyawan Rumah Sakit Ukrida Kartika, Ronald Winardi; Liem, Jen Fuk; Widjaja, Daniel
Health and Medical Journal Vol 6, No 3 (2024): HEME September 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i3.1616

Abstract

Latar belakang: Pengambilan data pemeriksaan Kesehatan dengan bantuan kecerdasan buatan sedang dikembangkan. Rumah sakit UKRIDA  sedang mengembangkan sistem Ukrida Chatbot untuk meningkatkan efisiensi dan efektivitas proses pengambilan data pra-medis (Pra MCU) yang sebelumnya menggunakan Formulir Online. Tinjauan literatur ini bertujuan untuk mengkaji literatur yang ada mengenai implementasi Ukrida Chatbot dalam layanan Pra MCU di Rumah Sakit Ukrida. Metode: Pencarian sistematis dilakukan di database jurnal ilmiah, termasuk Scopus, untuk mengidentifikasi penelitian yang terkait dengan penggunaan teknologi digital, khususnya kecerdasan buatan, dalam pengumpulan dan analisis data kesehatan pasien untuk layanan Pra MCU. Referensi yang dipilih mencakup publikasi tentang manfaat, tantangan, dan keberhasilan implementasi sistem serupa di lingkungan layanan kesehatan. Hasil: Tinjauan literatur menunjukkan bahwa kolaborasi Rumah Sakit Ukrida dalam pengembangan dan penerapan Ukrida Chatbot telah memberikan beberapa manfaat, seperti peningkatan efisiensi dalam proses pengumpulan data pasien awal, identifikasi awal faktor risiko, dan peningkatan keterlibatan pasien dalam pemantauan kesehatan mereka. Penggunaan teknologi Chatbot di Rumah Sakit Ukrida juga telah berkontribusi terhadap keberhasilan program pra MCJ. Kesimpulan: Pengalaman Rumah Sakit Ukrida dalam mengadopsi Ukrida Chatbot dalam pengumpulan data awal pasien pra MCU Karyawan RS UKRIDA
Co-Authors Irsan Hasan Kris Herawan Timotius Liem, Jen Fuk Sartika, Katarina Dewi Suradji, Eka Widrian Susanti, Yosephin Sri Tendean, Marcel Widjaja, Daniel Winata, Susanti Dewi Yong, Bernard Jonathan Christian