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Emy Susanti
Jurusan S1 Farmasi, Fakultas Farmasi, Universitas Wahid Hasyim Jl. Menoreh Tengah X/22, Sampangan, Semarang 50236
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Mechanical Engineering Medicine & Pharmacology

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PENGARUH VARIASI KONSENTRASI TWEEN 80 dan SPAN 80 TERHADAP KARAKTERISTIK KRIM EKSTRAK ETANOL DAUN NANGKA Susanti, Emy; Budiarti, Aqnes; Musyafaah, Maul
CENDEKIA EKSAKTA Vol 6, No 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.3036

Abstract

ABSTRACT Jackfruit leaves (Artocarpus heterophyllus) are known to have antioxidant activity and formulated in cream. Span 80 and tween 80 are emulsifiers that are widely used in cream formulations. This study aims to determine the antioxidant activity in cream preparations and the effect of concentrations span 80 and tween 80 on the physical characteristics of the cream.The ethanol extract of jackfruit leaves was made by maceration using 70% ethanol. Jackfruit ethanol extract cream is made in 4 formulas based on variations in the concentration of emulgator span 80; tween 80 that is F1 (3%; 3%), F2 (4%; 4%) and F3 (5%; 5%). The cream tested the physical characteristics of the cream including organoleptic, homogeneity, pH, adhesion, spreadability and viscosity, while antioxidant activity carried out by DPPH (1,1-Diphenyl-2-picrylhidrazyl) method. Data on the physical characteristics of the cream obtained were analyzed using linear regression, the results of organoleptic test and homogeneity were analyzed descriptively, and data from the activity of antioxidant creams were statistically tested using One Way Anova. The results obtained showed variation in concentrations of span 80 and tween 80 affecting the physical characteristics of the cream. Increasing the concentration of span 80 and tween 80 in cream preparations can increase viscosity and adhesion but reduce the spreadability. Antioxidant activity of jackfruit leaf ethanol extract obtained from F1 was 23.17%, F2 37.89% and F3 29.82%, significantly different with F(-) was 6.65%,. Variation in concentrations of span 80 and tween 80 do not affect their antioxidant activity. Keywords: Antioxidant, Jackfruit leaf, DPPH, Cream
STANDARISASI SIMPLISIA BERDASARKAN PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETHANOL 96% DAUN WARU (Hisbicus tiliaceus L.) Susanti, Emy
CENDEKIA EKSAKTA Vol 6, No 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v5i2.3734

Abstract

Sumber daya alam hayati (SDHA) menjadi semakin menarik diminati oleh masyarakat Indonesia dan bahkan dunia sebgai bahan baku obat-obatan tradisional (jamu) (Sukara E, 2002).Hal ini tampak dengan semakin meningkatnya pemakaian jamu dan industry obat tradisional yang terus semakin berkembang dari tahun ke tahun.Dalam kondisi seperti ini, upaya yang paling tepat adalah mendorong pengembangan obat ke arah fitofarmaka (Yuliani S, 2001).Salah satu tanaman yang berpotensi dikembangkan dalam dunia pengobatan adalah daun waru (Hisbicus Tiliaceus L.), namun penelitian tentang daun waru masih jarang dilakukan.Daun waru (Hisbicus Tiliaceus L.) mengandung senyawa polifenol, saponin dan flavonoid. Akar waru mengandung senyawa tanin, saponin, dan flavonoid (Kumar dkk., 2008). Kulit batang waru mengandung senyawa hibiscusamide, N-trans feruloyltiramine, dan N-cis feruloyltiramine dan bersifat toksik pada sel kanker kolon HT-29 dengan LC50< 4 μg/mL (Chen dkk., 2006). Hasil penelitian menunjukkan bahwa Standarisasi Simplisia Berdasarkan Parameter Spesifik Dan Non Spesifik Ekstrak Ethanol 96% Daun Waru (Hisbicus Tiliaceus L.) Kata Kunci: Daun Waru, Parameter Spesifik dan Non Spesifik, Standarisasi Simplisia
PENGARUH VARIASI KONSENTRASI TWEEN 80 dan SPAN 80 TERHADAP KARAKTERISTIK KRIM EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) SEBAGAI ANTIOKSIDAN Emy Susanti; Aqnes Budiarti; Maul Musyafaah
CENDEKIA EKSAKTA Vol 4, No 2 (2019)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v4i2.3052

Abstract

ABSTRACT Jackfruit leaves (Artocarpus heterophyllus) are known to have antioxidant activity and formulated in cream. Span 80 and tween 80 are emulsifiers that are widely used in cream formulations. This study aims to determine the antioxidant activity in cream preparations and the effect of concentrations span 80 and tween 80 on the physical characteristics of the cream.The ethanol extract of jackfruit leaves was made by maceration using 70% ethanol. Jackfruit ethanol extract cream is made in 4 formulas based on variations in the concentration of emulgator span 80; tween 80 that is F1 (3%; 3%), F2 (4%; 4%) and F3 (5%; 5%). The cream tested the physical characteristics of the cream including organoleptic, homogeneity, pH, adhesion, spreadability and viscosity, while antioxidant activity carried out by DPPH (1,1-Diphenyl-2-picrylhidrazyl) method. Data on the physical characteristics of the cream obtained were analyzed using linear regression, the results of organoleptic test and homogeneity were analyzed descriptively, and data from the activity of antioxidant creams were statistically tested using One Way Anova. The results obtained showed variation in concentrations of span 80 and tween 80 affecting the physical characteristics of the cream. Increasing the concentration of span 80 and tween 80 in cream preparations can increase viscosity and adhesion but reduce the spreadability. Antioxidant activity of jackfruit leaf ethanol extract obtained from F1 was 23.17%, F2 37.89% and F3 29.82%, significantly different with F(-) was 6.65%,. Variation in concentrations of span 80 and tween 80 do not affect their antioxidant activity. Keywords: Antioxidant, Jackfruit leaf, DPPH, Cream
Co-Authors Budiarti, Aqnes Budiarti Maul Musyafaah Musyafaah, Maul