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Sutjiatmo, Afifah B
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Dentistry

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NATURAL PRODUCTS PHARMACEUTICAL STANDARDIZATION TOWARDS PHYTOPHARMACA FOR INDONESIAN TRADITIONAL MEDICINE DEVELOPMENT: STANDARDISASI FARMASITIKAL BAHAN ALAM MENUJU FITOFARMAKA UNTUK PENGEMBANGAN OBAT TRADISIONAL INDONESIA Yuslianti, Euis Reni; Bachtiar, Boy M; Suniarti, Dewi Fatma; Sutjiatmo, Afifah B
Dentika: Dental Journal Vol. 19 No. 2 (2016): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.925 KB) | DOI: 10.32734/dentika.v19i2.463

Abstract

There is a tendency back to nature treatment in Indonesian community because modern/synthetic medicines is expensive and have a various alarming side effects. That is why natural products medicine becomes more popular, aside from mass media promotions. Researches on natural products such as herbal medicine increases along with the desire to get phytofarmaca that can compete with modern medicines. The aims of this literature review are to discuss and provides information on pharmaceutical standardization of natural products toward phytopharmaca for developing Indonesian traditional medicine. Pharmaceutical standardization will strengthen the basic of pharmaceutical science in producing safe, efficacy, and qualify traditional medicine products. The pharmaceutical standardization consists of standardizing simplicial quality, safety, efficacy, and stable formulation of medicines for use in health services.
Antioxidant and Antiaging Assays of Ageratum conyzoides (L.) Ethanolic Extract Sutjiatmo, Afifah B; Edriayani, Novi; Mulyasari, Tira Endang; Hermanto, Faizal; Fahrauk, M.; Sukandar, Elin Y.; Kusuma, Hanna Sari Widya; Rizal, Rizal; Widowati, Wahyu
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The declining ability of tissues to repair or replace themselves and maintain their structure and normal function is called aging. Aging is caused by free radical that can induce the activation of elastase and collagenase. Ageratum conyzoides (L.) or known as Babadotan is a medicinal plant that has been reported to be a good source of antioxidants that also inhibit aging process. The purpose of this research is to evaluate the antioxidant and antiaging properties of Babadotan Ethanolic Extract (BEE). Franswoth method was used to determine the phytochemical assay of BEE. Measurement of 2,2-diphenyl 1-picrylhydrazyl (DPPH) scavenger was used for antioxidant assay, and inhibitory of elastase and collagenase activities was used for antiaging assay. The analysis of phytochemical compounds exhibited the presence of flavonoids, alkaloids, tannins, polyphenols, steroids and triterpenoids, monoterpenoids and terpenoids, and the absence of saponin. BEE has lower activity on DPPH scavenging activity (IC50 = 80.7 µg/mL) than quercetin (IC50 = 3.25 µg/mL). BEE exhibited lower elastase and collagenase inhibitory activity (IC50 = 45.35 ± 2.2 µg/mL and 55.07 ± 1.1 µg/mL, respectively) compared to quercetin (IC50 = 11.64 ± 0.67 µg/mL and 19.91 ± 0.46 µg/mL). Overall, BEE possesses antioxidant and antiaging activities, although the activities are lower than quercetin.
Co-Authors Boy M Bachtiar Dewi Fatma Suniarti Edriayani, Novi Fahrauk, M. Faizal Hermanto Hanna Sari Widya Kusuma, Hanna Sari Widya Mulyasari, Tira Endang Rizal Rizal Sukandar, Elin Y. WAHYU WIDOWATI Yuslianti, Euis Reni