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Narlan Sumawinata
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Dentistry

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APPLICATION OF GLASS IONOMER CEMENT (GIC) FOR REPAIRING DENTAL PULP BY MEASURING EXPRESSION OF DENTIN MATRIX PROTEIN-1 : APLIKASI SEMEN IONOMER KACA UNTUK PERBAIKAN PULPA GIGI DENGAN MENGUKUR EKSPRESI DENTIN MATRIKS PROTEIN-1 Endang Suprastiwi; Siti Mardewi Soerono Akbar; Narlan Sumawinata; Ellyza Herda
Dentika: Dental Journal Vol. 17 No. 4 (2013): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.863 KB) | DOI: 10.32734/dentika.v17i4.1777

Abstract

Glass ionomer cement (GIC) has a potential to improve the pulp by inducing Dentin Matrix Protein-1 (DMP-1) release that can mineralize dentin. This study used three types of glass ionomer cements; Conventional GIC i.e. GC Fuji IX; resin-modified glass ionomer cement (RMGIC) i.e. GC Fuji II LC and Nano particle of RMGIC i.e. Ketac™ N100 3MEspe. The three materials were applied to the tooth pulp of Macaca nemestrina. Expression of DMP-1 extract-dental pulp of the subjects was investigated by using ELISA. This study was statistically analyzed by using Mann-Whitney test. The result showed that GICs has a potential to induce the expression of DMP-1 and there was no significant differences among the three groups of GIC to induce DMP-1(p≥ 0,05). In conclucion, all tested materials have a potential in dental pulp repair by expressing DMP-1.
EFFECT OF LATEX AND EXTRACT OF JATROPHA CURCA LINN ON EXPRESSION OF SUBSTANCE P (SP) AND CYCLOOXYGENASE-2 OF DENTAL PULP: EFEK LATEKS DAN EKSTRAK JATROPHA CURCA LINN TERHADAP EKSPRESI SUBSTANSI P DAN COX2 PULPA GIGI Irmaleny; Narlan Sumawinata; Dewi Fatma
Dentika: Dental Journal Vol. 16 No. 1 (2011): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.431 KB) | DOI: 10.32734/dentika.v16i1.1896

Abstract

Inflammatory pulpal pain may arise due to the increased pressure inside the pulp or the release of prostaglandin E2(PGE2). In the inflamed pulp, levels of PGE2 and substance P (SP) is higher than those of normal pulp. PGE2 sensitizes all nociceptor while SP can induce the activity of cyclooxygenase-2 (COX- 2) and is an exitatory neurotransmitter. Jatropha curcas Linn latex is widely used for pulpal pain relief. The aim of this study was to evaluate the effect of the latex and extract of J. curcas on the dental pulp expression of COX-2 and SP. Thirty-six pulpitis-induced dental pulp of Macaca fascicularis , were divided into 3 groups: Group 1 served as controls, Group 2 was given latex, and Group 3 was given extracts. The ELISA assay was used to determine the levels of SP and COX-2. SP data was analyzed with ANOVA (p <0.05) while the COX-2 data was analyzed with Mann Whitney. The results showed that the levels of SP (pg/mL) of the control, latex, and extract group were 28.94; 26.22; 28.89 respectively, while levels of COX-2 (ng/ml) of control, latex, and extract group were 0.04; 0.08; 0.10 respectively. In conclusion , J. curcas can reduce the levels of SP, J. curcas latex has lower levels of SP than extract, but does not provide clear results in decreased levels of COX- 2. Further study requires the mechanism of SP, and the concentration of COX- 2 needs to be further investigated using different methods.
Co-Authors Dewi Fatma Ellyza Herda Endang Suprastiwi Irmaleny Siti Mardewi Soerono Akbar