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All Journal Bali Dermatology and Venereology Journal Journal of General-Procedural Dermatology & Venereology Indonesia
Batan, Putu Nila Wardhani
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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The positive correlation between serum malondialdehyde levels with vitiligo severity and activity Praharsini, I Gusti Ayu Agung; Wiraguna, Anak Agung Gde Putra; Batan, Putu Nila Wardhani
Bali Dermatology and Venereology Journal Vol 2, No 1 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.63 KB) | DOI: 10.15562/bdv.v2i1.17

Abstract

Background: There are several theories that suggest melanocyte death in vitiligo, one example is oxidative stress theory. Oxidative stress primarily manifested by lipid peroxidation ultimately produce malondialdehyde. Malondialdehyde is a stable marker to assess an oxidative stress event. The correlation between serum malondialdehyde levels and vitiligo severity and activity remained controversial in previous studies.Objective: This study aimed to verify whether or not the serum MDA levels are positively correlated with vitiligo severity and activity.Methods: This study was an analytical cross-sectional study. which involved 64 subjects with vitiligo and 20 subjects without vitiligo. Serum MDA levels were measured to mark an oxidative stress event, whereas the severity and activity of vitiligo were clinically assessed with vitiligo area severity index (VASI) and vitiligo disease activity (VIDA) scoring system.Results: Total 64 subjects with vitiligo and 20 subjects without vitiligo participated in this study. Serum MDA mean levels of vitiligo subjects were significantly higher compared to subjects without vitiligo (p<0.05). Serum MDA levels had a strong positive correlation with VASI score (r=0.761; p<0.01). The strong positive correlation found between serum MDA levels with vitiligo activity assessed by VASI score in vitiligo subjects (r=0.609; p<0.01), and high serum MDA levels increased the risk for developing vitiligo (PR=7.62; 95% CI: 2.49-23.30; p<0.01). Serum MDA levels influenced vitiligo as much as 10.1%, meanwhile the remaining 89.9% were influenced by other variables apart from high serum MDA levels out of this study (R2=0.101; p<0.05).Conclusion: Serum MDA levels were positively correlated with vitiligo severity and activity, and high serum MDA levels increased the risk of developing vitiligo.
Association between obesity and history of atopy with atopic dermatitis in children: A cross-sectional study Batan, Putu Nila Wardhani; Ariana, Ariana; Wardhana, Made
Journal of General - Procedural Dermatology & Venereology Indonesia
Publisher : UI Scholars Hub

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Abstract

Background: The prevalence of atopic dermatitis (AD) has rapidly increased in the past 4 decades and has been mostly observed in children. The prevalence of obesity has also significantly increased worldwide, suggesting that the two conditions may be associated. Methods: This retrospective analytic study involved a cross-sectional design and used secondary data taken from the medical record of patients who visited the Pediatric Dermatology Subdivision at Dermatology and Venereology Polyclinic Sanglah General Hospital from January 2015 to December 2015. Thirty-two samples were selected. Results: The prevalence ratio of obesity among subjects with AD was 2.178 (95% CI = 1.034–4.587; p < 0.05), which indicated a significant association between obesity and AD. This study also found a significant association between the history of atopy and AD, and the prevalence ratio was 2.566 (95% CI = 1.099–5.990; p < 0.05). The risk of developing AD among children with obesity was higher than that among children without obesity. Conclusion: Obesity and history of atopy were significantly associated with AD in children.
Co-Authors Anak Agung Gde Putra Wiraguna Ariana Ariana I Gusti Ayu Agung Praharsini Made Wardhana