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Niah, Rakhmadhan
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Agriculture, Biological Sciences & Forestry

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POTENSI EKSTRAK DAUN TANAMAN KARAMUNTING (Melastoma malabathricum L.) DI DAERAH KALIMANTAN SEBAGAI ANTIBAKTERI Staphylococcus aureus Niah, Rakhmadhan; Baharsyah, Riki Nirwan
Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.285 KB)

Abstract

The year 2008 recorded the death toll reached 16,769 soul due to infection. Infection is one of the diseases caused by bacteria or parasites. Staphylococcus aureus is one of the bacteria causes infection of the skin that is often the case in Indonesia. Staphylococcus aureus bacterial infection can be treated naturally, one of the plants that can be utilized is plant karamunting. Plant leaf karamunting (Melastoma malabathricum l.) contain flavonoids and alkaloids that have activity as antibacterial. The purpose of this research is to know the power of drag karamunting folium of extract against the growth of Staphylococcus aureus. In vitro studies were conducted with diffusion agar method. The extraction of leaf maceration method done with karamunting solvent ethanol 96%. Concentration of karamunting folium of extract used are: 25%, 50%, 75%, and 100%. Microbiology research results indicate that karamunting folium of extract have drag against the growth of bacteria Staphylococcus aureus with extract concentration 50% yield of 5.34 mm; the concentration of extract 75% of 9.40 mm; the concentration of extract 100% of 12.43 mm.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL KULIT PISANG KEPOK MENTAH SECARA IN VITRO Ariani, Novia; Niah, Rakhmadhan
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.664 KB) | DOI: 10.51352/jim.v5i2.270

Abstract

The incidence of infections in the gastrointestinal tract is increasing every year. Some bacteria that often cause infections in the gastrointestinal tract are Salmonella typhi, which is a bacterium that causes typhoid fever, and Shigella dysenteriae which is a bacterium that causes dysentery. Handling of infection can only be done by using antibiotics. Improper use of antibiotics can lead to resistance, so it is necessary to look for alternative treatments that come from nature to overcome resistance levels. One of them is raw Kepok banana peel (Musa paradisiaca formatypica) which has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, where these compounds have many antibacterial activities unknown to the public. This research was an experimental research. The extraction method was using the maceration method with 96% ethanol solvent. Antibacterial activity test for Salmonella typhi and Shigella dysenteriae was using diffusion method therefore the wells were divided into 7 treatment groups, namely extract concentration 0.3125%; 0.625%; 1.25%; 2.5%; 5.0%; positive control (Chloramphenicol dose 30 mg / ml for Salmonella typhi, Ciprofloxacin dose 100 mg / ml for Shigella dysenteriae), and negative control (ethanol 96%). The diameter of the inhibitory zone formed was then measured using a caliper. From the results of the research that has been done, it was found that the ethanol extract of raw Kepok banana peel (Musa paradisiaca forma typica) had inhibitory effect on the growth of Salmonella typhi and Shigella dysenteriae bacteria with the highest inhibition zone diameter of 11.36 mm and the lowest 6.45 mm for Salmonella typhi, and the highest inhibition zone for Shigella dysenteriae was 17.99 mm and the lowest was 15.13 mm. The minimum concentration of banana skin ethanol extract which had inhibitory power was 0.3125%.
KEMAMPUAN PENGHAMBATAN RADIKAL BEBAS HAND SANITIZER EKSTRAK METANOL DAUN SEPAT(Mitragynaspeciosa) Niah, Rakhmadhan; Ariani, Novia
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.126 KB) | DOI: 10.51352/jim.v6i1.314

Abstract

Leaves Sepat (Mitragynaspeciosa) is a plant of Kalimantan. These plants are often used traditionally to reduce blood sugar and antibacterial. The effectiveness is related with strong antioxidant activity in flavonoid compounds. Flavonoid compounds work through the mechanism of capturing free radicals, reducing oxidative stress. The purpose of this study was to measure the percentage of free radical inhibition in the hand sanitizer of methanol extract of leaves Sepat (Mitragynaspeciosa). Sample extraction by maceration method using methanol. Qualitative analysis of chemical compounds with certain eluents using Thin Layer Chromatography (TLC). The antioxidant activity test using the DPPH immersion method (1,1-Diphenyl-2-picryl Hidrazil) measured absorption at a wavelength of 517 nm. The largest percentage of free radical inhibition was obtained in a hand sanitizer concentration of 80 ppm, which is 51.07 ppm.
Co-Authors Ariani, Novia Baharsyah, Riki Nirwan