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All Journal Jurnal Saintika Medika
Aulia, Yusrin
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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EFEK ANTI INFLAMASI EKSTRAK ETANOL WORTEL (DAUCUS CAROTA L.) TERHADAP TIKUS STRAIN WISTAR (RATTUS NOVERGICUS) YANG DIINJEKSI KARAGENAN Aulia, Yusrin; Safitri, Fathiyah; Fadilah, Rahmiyah
Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol 9, No 2 (2013): Desember 2013
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.22219/sm.v9i2.4131

Abstract

Efek Anti Inflamasi Ekstrak Etanol Wortel (Daucus carota L.) terhadap Tikus Strain Wistar (Rattus Novergicus) yang Diinjeksi Karagenan. Latar Belakang: Inflamasi merupakan respon fisiologis terhadap kerusakan jaringan. Inflamasi biasa diobati dengan golongan NSAID dan kortikosteroid yang memiliki efek samping cukup banyak. Wortel mengandung flavonoid yang menghambat enzim fosfolipase dan cyclooxygenase, serta saponin yang menghambat peningkatan permeabilitas vaskuler. Tujuan: Untuk membuktikan ekstrak etanol wortel (Daucus carota L.) memiliki efek anti inflamasi terhadap tikus strain wistar (Rattus novergicus) yang diinjeksi karagenan. Metode: Penelitian eksperimental dengan The Pre and Post Test Control Group Design, menggunakan 4 kelompok: (1) kontrol, (2) perlakuan dosis 100 mg/kgBB, (3) perlakuan dosis 200 mg/kgBB, dan (4) perlakuan dosis 400 mg/kgBB. Analisis data menggunakan uji One-Way ANOVA, HSD Tukey 5%, korelasi Pearson, dan regresi linier. Hasil dan Diskusi: Ekstrak etanol wortel meningkatkan prosentase reduksi radang secara bermakna (ANOVA p<0,05) dengan signifikansi 0,000. Hal ini diduga karena kandungan flavonoid serta saponin pada wortel. Dosis ekstrak wortel yang memberikan efek anti inflamasi paling besar pada penelitian ini adalah 400 mg/kgBB. Uji regresi linier menunjukkan ekstrak wortel berpengaruh 46,6% terhadap inflamasi. Kesimpulan: Ekstrak etanol wortel memberikan efek anti inflamasi terhadap tikus strain wistar yang diinjeksi karagenan.
The Efficacyofantiscabies Medicinetohealing Scabiesin Patient Who Received Personal Hygiene Education Tunjungsari, Feny; Tamtomo, Didik; Murti, Bhisma; Aulia, Yusrin
Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol 15, No 2 (2019): December 2019
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.364 KB) | DOI: 10.22219/sm.Vol15.SMUMM2.10559

Abstract

The prevalence of the scabies disease in a populated area (e.g islamic boarding schools)is still high .It is possible that disease skabies are still found here because the higiene individuals from the community .Skabies disease is easily treated , but to progress , the disease remains a big problem in the specific community health .This study attempts to analyze the effectiveness of an anti skabies permethrine comparedgameksanto healing patients whohas been getting an  individuals higiene educationSamples were 40 student the Islamic boarding in the malang district the age range of 12 - 18 years taken by random. The dependent variable was cure from scabies. The independent variable included anti-scabies (Gamexan and Permethrine). The sample taken as random.Research will be tested using chi-square to analized the data.The experimental work on chi square statistically from the analysis does not obtain a significant relation ( p = 1,000 ) between the provision of treatment antiscabies gameksan and permethrine with healing on the subjects of research get education higiene individuals.Although statistically no meaning, but can be concluded that clinically better to use gameksan and permethrine, if the subject of study get education nice about education higiene individuals, there is no different effect between the provision of gameksan with permethrine.
Co-Authors Bhisma Murti Didik Tamtomo, Didik Fadilah, Rahmiyah Feny Tunjungsari Safitri, Fathiyah