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All Journal The New Ropanasuri Journal of Surgery Jurnal Ilmu Bedah Indonesia
Megatia, Ika
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Triple Diagnostic Accuracy on Early Stage Breast Cancer at dr. Cipto Mangunkusumo and Persahabatan General Hospital Kartini, Diani; Megatia, Ika; Darmiati, Sawitri; Rustamadji, Primariadewi; Budiningsih, Setyawati
The New Ropanasuri Journal of Surgery
Publisher : UI Scholars Hub

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Abstract

Introduction. Breast cancer is the most common cancer in Indonesia with incidence rate 40.3 per 100.000 women and mortality rate 16.6 per 100.000women. On early stage, the decision for operative procedure (i.e. mastectomy) requires intraoperative frozen section to assess malignancy; which is mostly unavailable in secondary hospitals. The triple diagnostic (TD) test consists of physical examination, breast ultrasonography and fine needle aspiration biopsy is an accurate and simple preoperative diagnostic method that may solve the problem. The study aimed to find out conformance of the triple diagnostic to histopathology findings in those with breast lump where the malignancy was suspected. Method. A study of diagnostic accuracy conducted enrolling subjects with suspected malignant breast lump managed in dr Cipto Mangunkusumo General Hospital (RSCM) and Persahabatan Hospital (RSP) in period of February 2016 to August 2017 who met the criteria: those underwent preoperative triple diagnostic, intraoperative frozen section and histopathology examination. The conformance of TD and frozen section were compared to histopathology findings. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were the focuses of the study. Results. There were 33 subjects enrolled (prevalence of 4.3%), mean age of 49.6 years ± 10.9, were above 40 years (78.8%). Tumor size of 2–5 cm found in 63.6% subjects, and the most histopathology finding was invasive carcinoma (84.8%). Frozen section showed sensitivity of 96.8%, specificity of 100%, PPV of 100%, NPV of 66.7% and accuracy of 97.0%. TD showed sensitivity of 77.4%, specificity of 100%, PPV of 100%), NPV of 22.2% and accuracy of 78.8% (p = 0.016). Conclusion. Triple diagnostic reaches up to 78% accuracy on early stage breast cancer may be used secondary hospital in Indonesia whenever frozen section is unavailable.
Keberhasilan Venoplasti untuk Mengatasi Stenosis Akibat Pemasangan CDL pada Vena Sentral di Rumah Sakit Dr. Cipto Mangunkusumo Megatia, Ika; Darwis, Patrianef
Jurnal llmu Bedah Indonesia Vol 46 No 1 (2018): Artikel Penelitian
Publisher : Ikatan Ahli Bedah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46800/jibi-ikabi.v46i1.32

Abstract

Latar Belakang: Dalam lima tahun terakhir, pengunaan kateter pada pasien penyakit ginjal kronis (PGK) di RSCM kerap diikuti stenosis vena sentral (SVS, 60-70%). Sejak 2013 SVS ditangani melalui prosedur venoplasti, namun belum ada evaluasi keberhasilan. Penelitian ini ditujukan melakukan evaluasi keberhasilan venoplasti dan faktor risiko terjadinya stenosis. Metode: Dilakukan studi deskriptif analitik dengan desain potong lintang melibatkan pasien PGK stadium 4-5 yang terdiagnosis simptomatik SVS, secara klinis dan radiologis, yang memiliki risiko stenosis, memenuhi kriteria inklusi dan ekslusi serta menjalankan venoplasti. Variabel independen yaitu onset gejala, jenis, lokasi, durasi dan frekuensi pemasangan kateter. Variabel dependen adalah keberhasilan venoplasti dinilai dengan residual stenosis <30%. Data dianalisis secara statistik dengan p = 0,05. Hasil: Tercatat 34 subjek, 73,5% berusia >60 tahun, 61,8% laki-laki dan 70,6% memiliki hipertensi sebagai etiologi PGK. Angka berhasilan venoplasti 85,3%, nilai rerata initial stenosis adalah 79,1±13,8% dan median residual stenosis 24,5% dengan range 10-90%. Letak stenosis terbanyak di vena subklavia (47,1%). Tidak didapatkan hubungan bermakna terhadap keberhasilan venoplasti, namun angka ketidakberhasilan venoplasti yang lebih tinggi ditemukan pada lokasi di vena subklavia (OR 2,45; p = 0,627) dan frekuensi pemasangan kateter >2 kali (OR 1,85; p = 0,648). Simpulan: Keberhasilan venoplasti pada SVS 85,3% dengan keberhasilan ditemukan dua kali lebih tinggi pada implantasi di vena subklavia dan frekuensi > 2 kali. Namun pada studi ini tidak bermakna secara statistik. Ketidakberhasilan venoplasti lebih sering ditemukan pada subjek dengan pemasangan kateter di vena subklavia, durasi pemasangan panjang, onset gejala lambat dan riwayat pemasangan berulang.
Co-Authors Darmiati, Sawitri Darwis, Patrianef Kartini, Diani Primariadewi Rustamadji Setyawati Budiningsih