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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN International Journal of Research Innovation and Entrepreneurship
Setiyorini, Nurul
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Health Professions Medicine & Pharmacology Social Sciences

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Optimization of Terpenoid Extraction from Bay (Syzygium polyanthum) Leaves using Ethanol as a Solvent by an Ultrasonic Wave Technology Kusumaningrum, Maharani; Prasetiawan, Haniif; Setiyorini, Nurul; Dewanti, Astiara Anis; Rengga, Wara Dyah Pita
International Journal of Research Innovation and Entrepreneurship Vol 1 No 1 (2020): June 2020
Publisher : Universitas Negeri Semarang

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Abstract

Bay is one of the medicinal plants. Bay leaves have been used in the pharmaceutical and food industry as an antimicrobial. The chemical compounds in the leaves that served as an antimicrobial were terpenoids. This study aims to determine the optimum extraction conditions of bay leaves using a response surface methodology (RSM). Ten grams of dried and mashed bay leaves was extracted for 60 minutes using ethanol as a solvent. The extraction was conducted at various temperatures (60, 70, 80 oC) and various ratios of the starting material to solvent (1: 8, 1:10, 1:12 g/g) for 60 min. The optimum extraction condition based on the RSM results was achieved at 70 °C with a ratio of the starting material to solvent of 1:12 g/g resulting in the extract yield of 9.69%. The results of the GC-MS analysis on the obtained extracts showed that 33% of terpenoids was obtained from the extraction at the optimum condition.
Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia Setiyorini, Nurul; Cahyanti, Ratnasari Dwi
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2020): July-December 2020
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2092.55 KB) | DOI: 10.30659/sainsmed.v11i2.10919

Abstract

Introduction: preeclampsia/eclampsia contributed to 30% of maternal mortality in RSUP Dr. Kariadi. Pre-induction bishop score assessment is a standard for cervical maturity estimation. Other predictors currently being developed, including insulin-like growth factor binding protein-1 (IGFBP-1). However, there is no cut-off point for IGFBP-1 examination in full term pregnancy, especially with preeclampsia and its complications. Objective: to find IGFBP-1 levels and Bishop Score differences in preeclampsia women with induction labor.Methods: this prospective observational cohort study was conducted in preeclampsia women with gestational age ≥37 weeks planned labor induction at Obstetrics and Gynecology Ward RSUP Dr. Kariadi Semarang and networking hospital during study period (n=66). History taking, physical examination, proteinuria, cervical mucus IGFBP-1, and bishop score calculation was performed. Statistical analysis was performed with paired-t test, followed by ROC for cut-off value of successful induction prediction, and logistic regression to determine confounding variables effect on IGFBP-1 levels.Results: The average Bishop score of 66 subjects was 2.5±1.81 and 2.6±1.8 for women who deliver ≤24 labor and in labor for ≤12 hours, respectively. Although the bishop score was higher in the successful labor group, there was no significant difference between groups. Mean IGFBP-1 value was 8.29±5.033 mcg/L with median value of 10.8 mcg/L. Successful induction had significant higher IGFBP-1 levels with area-under-curve (AUC) 0.76 and 8.145 cutoff value (p=0.002, RR=5.1).Conclusion: IGFBP-1 level with cutoff point 8.145 can be used as predictor of successful labor induction in term pregnancy with preeclampsia.
Co-Authors Dewanti, Astiara Anis Maharani Kusumaningrum Prasetiawan, Haniif Ratnasari Dwi Cahyanti, Ratnasari Dwi W.D.P Rengga