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All Journal JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Journal La Medihealtico Buletin Kedokteran dan Kesehatan Prima
Wardhani, Fiska Maya
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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EFEK EKSTRAK CURCUMA ZEDOARIA TERHADAP GULA DARAH DENGAN MODEL TIKUS DIABETES TIPE 2 Asthariq, Miftah; Dita, Bunga Tiara; Wardhani, Fiska Maya
(Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Vol 5, No 4 (2020): JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat)
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37887/jimkesmas.v5i4.15058

Abstract

Penyebab mortalitas dari 1,5 juta jiwa di dunia pada tahun 2012 adalah Diabetes melitus (DM) dankomplikasinya, Salah satu senyawa dalam kunyit putih yaitu flavonoid bermanfaat dalam menghindari absorpsiglukosa atau memperbaiki toleransi glukosa. Flavonoid dapat menstimulasi penangkapan glukosa di jaringanperifer, lalu mengatur aktivitas dan ekspresi enzim pada jalur metabolism karbohidrat dan bertindak sepertimenyerupai insulin.Tujuan Riset terhadap gula darah tikus jantan ini dilakukan guna mengetahui efek ekstrakcurcuma zedoaria pada dosis 250, 500, 750 mg/kgBB. Penelitian ini menggunakan metode eksperimental denganrancangan the one group test only design, cara melakukan uji efektifitas ini adalah dengan cara memasukkankonsentrasi dari ekstrak curcuma zedoaria kepada tikus selama 14 hari lewat oral dengan dosis berbeda (250,500, 750 mg), uji kruskal wallis dipilih sebagai metode pengolahan data yang dapat digunakan didalam uji cobapenelitian ini, berdasarkan uji analisa kruskal Wallis terdapat pengaruh yang signifikan (p<0.05) antara ekstrakkunyit putih dan penurunan kadar gula dara tikus, dosis ekstrak kunyit yang paling efektif dalam menurunkankadar glukosa darah tikus adalah 500 mg/kgBB.Kata Kunci.: Efek ekstrak curcuma zedoaria, diabetes melitus
Histopathological characteristics of breast tumors at Madani General Hospital Medan Yunata, Kianie Engaline; Lina, Juliana; Wardhani, Fiska Maya
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5475

Abstract

Cytology and histopathology include examinations to diagnose breast tumors. The diagnosis of advanced stages of breast tumors can lead to reduced therapeutic options and success. This study aimed to describe the results of cytological and histopathological examinations of patients with breast tumors at the Anatomical Pathology Laboratory of Madani Medan General Hospital between the period 2018-2022. This study was descriptive and retrospective. The study population included all the medical records of patients diagnosed with breast tumors. The research sample consisted of the medical records of patients with FAM and Carcinoma Mammae obtained by consecutive sampling. The results of cytological and histopathological examinations showed that the majority of breast tumor patients were both aged 17-25 years with a percentage of 42.9% and 52.4%, respectively). The results of the cytological examination showed that the majority of patients had benign tumor diagnoses (85.7%) and histology (90.5%). Malignant tumors were diagnosed based on the results of cytological examination (14.3%) and histology (9.5%). Based on the relationship between age. Based on the relationship between age and diagnosis of benign and malignant tumors, the results of cytological examination showed that patients aged 12-16 years, 17-25 years, and 26-35 years all had benign tumors (100%), patients aged 36-45 years had benign tumors (50.0%) and malignant tumors (50.0%), and patients aged 56-65 years all had malignant tumors (100.0%). Histopathological examination results showed that patients aged 12-16 years, 17-25 years, 26-35 years, and 36-45 years all had benign tumors (100%), patients aged 46-55 years had benign tumors (50.0%) and malignant tumors (50.0%), and patients aged 56-65 years all had malignant tumors (100.0%).
Acute Toxicity Test of White Turmeric Extract (Curcuma Zedoaria) on Female Wistar Rat Endometrium Wardhani, Fiska Maya; Florenza, Audrey Gracella; Erny Tandanu; Azizoğlu, Azizoğlu
Journal La Medihealtico Vol. 4 No. 3 (2023): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v4i3.895

Abstract

Indonesia is a country that has very abundant natural biota resources. There are many types of plants that are often used in traditional medicine. One of the plants that is often used is white turmeric (Curcuma zedoaria). This study aimed to identify the toxic effects and determine the LD50 value of white turmeric extract. In this study, rats were divided into six groups with per-oral administration of the extract. After the administration of the extract, 24 hours of toxicity symptoms were observed, then the number of dead rats was recorded. On the 15th day, uterine organs were taken for histopathology observation. Based on the results of the tests that have been carried out, no toxic effects were found in rats, with a pseudo-LD50 value of >2000mg/kgBB. The conclusion of this study wa that there is no significant difference in endometrial histopathology such as epithelial proliferation at a dose of 2000mg/kgBW white turmeric extract with other groups (p=0.529).
Co-Authors Asthariq, Miftah Azizoğlu, Azizoğlu Dita, Bunga Tiara Erny Tandanu Florenza, Audrey Gracella Lina, Juliana Yunata, Kianie Engaline