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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia eJournal Kedokteran Indonesia Ophthalmologica Indonesiana
Laura Agnestasia Djunaedi
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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SELENIUM SEBAGAI TERAPI OFTALMOPATI GRAVES DERAJAT RINGAN Laura Agnestasia Djunaedi; Ferdy Iskandar; Cisca Kuswidyati
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v69i8.190

Abstract

Oftalmopati Graves (OG) merupakan manifestasi ekstra-tiroid tersering dari penyakit Graves. Sebanyak lebih dari 50% penderita Graves akan mengalami OG, bahkan 10% diantaranya menderita OG derajat berat. Mekanisme terjadinya OG berhubungan dengan reaksi autoimun yang sangat kompleks dan dicurigai juga berhubungan dengan ketidakseimbangan kadar antioksidan serta oksidan di dalam tubuh. Selain itu, faktor lingkungan (rokok) dan juga kontrol yang buruk dari penyakit Graves semakin memicu progresifitas dari oftalmopati.Salah satu komponen antioksidan yang paling banyak terdapat pada kelenjar tiroid adalah selenium. Selenium diharapkan dapat membantu mengatasi OG terutama pada derajat ringan dengan memperbaiki ketidakseimbangan antara kadar oksidan dan antioksidan di dalam tubuh. Namun, pemberian selenium tidak dapat dilakukan secara bebas karena pemberian dalam jumlah yang tidak tepat dapat memicu timbulnya beberapa jenis kanker dan juga diabetes mellitus tipe II.
The Prevalence of Myopia and its Associated Factors Among School-Aged Children in Pamijahan Village, Bogor District Julie Dewi Barliana; Yeni Dwi Lestari; Ghina Fedora; Laura Agnestasia Djunaedi; Anthea Casey; Tri Rahayu; Ratna Sitompul; Andi Arus Victor; Saleha Sungkar
eJournal Kedokteran Indonesia Vol 11, No. 1 - April 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.210.3-7

Abstract

Globaly, the prevalence of refractive errors, especially myopia in children, has increased significantly. The cause of myopia is multifactorial. Near-work activities and family history are some suggested factors associated with myopia. However, there has not been enough data on these factors and their association with myopia in Indonesia. This study aims to determine the prevalence and factors associated with myopia in primary and middle schoolaged children in Pamijahan Village, Bogor District, West Java, Indonesia. Data were taken in a cross-sectional design based on the visual acuity, anterior and posterior eye examination. A 14-item questionnaire regarding myopia-associated factors including family history, playing outdoors, and near-work activities, was distributed to the subjects. The data were taken from June to September 2018. Analysis was conducted using SPSS version 20. The prevalence of myopia in Pamijahan Village is 4,9% out of 474 subjects. Family history, including parental (p=0.001, OR 4.49) and sibling history (p=0.001, OR 5.58), was shown to be associated with the increasing risk of myopia in children while near-work activities and playing outdoors were not associated with myopia in children of Pamijahan Village.
Can Optical Coherence Tomography Angiography be a Useful Adjunctive Diagnostic Tool in Patient with Non Arteritic Ischaemic Optic Neuropathy? Poster Presentation - Case Series - Resident Laura Agnestasia Djunaedi; Syntia Nusanti; M. Sidik; Salmarezka Dewiputri; Sita Paramita
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/3zzp0093

Abstract

Abstract Introduction : Perfusion deficiency of the optic nerve head is presumed to have an immense role in the pathogenesis of non-arteritic ischaemic optic neuropathy (NAION). Optical coherence tomography angiography (OCTA) is a non-invasive method that can assess posterior pole vasculature at multiple levels. Thus, these case series want to compare the OCTA in the acute (before four weeks) and chronic phases (after six weeks) of NAION with their fellow unaffected eyes to give an overview of vasculature changes in NAION. Case Illustration : This case series consists of four patients with NAION. Half of them came with a sudden painless blurry vision, and the remaining presented with an abrupt visual field defect. All of them have diabetes mellitus and hypertension. None of them have superimposed vascular pathology. The first OCTA was taken within seven days of the first symptoms, and the second OCTA was taken more than six weeks after. Discussion : The high percentage of systemic vascular risk factors and the acute onset supported the vascular occlusive hypothesis in the pathogenesis of NAION. Meanwhile, the OCTA provides an actual overview of the vasculature changes. Microvasculature is more likely to expand in the acute phase, and a more significant expansion was found in greater optic disc edema. On the other hand, microvascular tend to attenuate in the chronic phase, representing the pruning of capillaries. A swept-source OCTA with deeper penetration might give a better peripapillary choriocapillaris image in the acute phase. Conclusion : OCTA is a promising adjunctive tool for diagnosing and monitoring progression in patients with NAION.
Co-Authors Andi Arus Victor Anthea Casey Cisca Kuswidyati Ferdy Iskandar Ghina Fedora Julie Dewi Barliana M. Sidik Ratna Sitompul Saleha Sungkar Salmarezka Dewiputri Sita Paramita Syntia Nusanti Tri Rahayu Yeni Dwi Lestari