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PERBEDAAN KADAR IL-6 PADA HUVECs NORMAL DENGAN HUVECs NORMAL YANG DIPAPAR PLASMA HAMIL PENDERITA PREEKLAMPSIA Rahayu, Budi; Nurdiana; Windu Baktiyani, Siti Candra
MEDIA ILMU KESEHATAN Vol 4 No 3 (2015): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.957 KB)

Abstract

Background : Preeclampsia is a condition where the blood pressure is increasing (≥140/90 mmHg) followed by proteinuria (≥300 mg/24 hour or ≥1+ in stick test) in pregnant women after 20 weeks of pregnancy. Released placenta factor cause the damage in endothelial cells which lead to the excessive increase on pro inflammation factor interleukin 6 (IL-6). Objective: This study aimed to investigate whether level IL-6 on normal HUVECs with normal HUVECs induced by plasma from preeclamptic patients. Research Method: True experimental research using posttest only control group approach, conducted in the laboratory with invitro. HUVECs culture was divided into 5, that were normal HUVECs without treatment (K-); HUVECs preeclampsia model (K+). Measurement on the levels of IL-6 used ELISA (Enzyme-Linked Immunosorbent Assay). Result: Independent sample t-test showed that there were significant differences (p=0.000<α) on the average of IL-6 levels between the negative control group (1.64±0.12 pg/ml) and the positive control group (31.64±11.69 pg/ml). Conclusion: Adding the patient’s preeclampsia plasma into normal HUVECs can increase levels of IL-6. Keyword: Patient’s preeclampsia plasma, HUVECs, and IL-6.
Prevention of dental caries with remineralization in containing Casein Phosphopeptid-Amorphous Calcium Phosphate (CPP-ACP) to students SD Swasta Muhammadiyah – 03 Medan Batubara, Fitri Yunita; M. Zulkarnain; Cut Nurliza; Nurdiana; Dewi Kartika
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.225 KB) | DOI: 10.32734/abdimastalenta.v4i2.4112

Abstract

Dental caries is an infectious disease caused by demineralization of enamel and dentin which is closely related to the consumption of cariogenic foods. Generally children entering school age have a high caries risk, because at this school age children usually like food and drink snacks as they wish. The impact that occurs when since the beginning has experienced caries is in addition to the function of the teeth as chewing that is disrupted, swollen gums, the child will also experience disturbances in carrying out their daily activities, so the child will not eat and consequently malnutrition can occur, this causes the child to be unable to study because of lack of concentration so that it will affect intelligence. The results of the field analysis and preliminary interviews with school leaders as partners in community service obtained data that students in Muhammadiyah Private Elementary School 03 Medan aged 6-8 years experienced dental caries with the characteristics of cavities, porous, and stains / plaques. These characteristics are related to the patterns or behavior of students who like to consume sweet foods like candy, bread, and chocolate. School Dental Health Efforts (UKGS) have also not been implemented in schools. Therefore, community service is needed to be carried out with a form of socialization prevention for early caries in order to provide knowledge of the main causes, ways of spreading, impact, efforts to prevent dental caries, and providing remineralization (dental caries prevention) containing Casein Phosphopeptid-Amorphous Calcium Phosphate (CPP-ACP) to students of grade II Muhammadiyah Primary School 03 Medan. Community service activities were carried out by five service teams from the Faculty of Dentistry, University of North Sumatra on August 27, 2019, involving as many as twenty two USU FKG students who were undergoing clinical clerkship. The socialization and provision of caries prevention materials to 111 students who were in grade II of Muhammadiyah Primary School - 03 Medan.
Prevention of dental caries with remineralization in containing Casein Phosphopeptid-Amorphous Calcium Phosphate (CPP-ACP) to students SD Swasta Muhammadiyah – 03 Medan Batubara, Fitri Yunita; M. Zulkarnain; Cut Nurliza; Nurdiana; Dewi Kartika
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.225 KB) | DOI: 10.32734/abdimastalenta.v4i2.4112

Abstract

Dental caries is an infectious disease caused by demineralization of enamel and dentin which is closely related to the consumption of cariogenic foods. Generally children entering school age have a high caries risk, because at this school age children usually like food and drink snacks as they wish. The impact that occurs when since the beginning has experienced caries is in addition to the function of the teeth as chewing that is disrupted, swollen gums, the child will also experience disturbances in carrying out their daily activities, so the child will not eat and consequently malnutrition can occur, this causes the child to be unable to study because of lack of concentration so that it will affect intelligence. The results of the field analysis and preliminary interviews with school leaders as partners in community service obtained data that students in Muhammadiyah Private Elementary School 03 Medan aged 6-8 years experienced dental caries with the characteristics of cavities, porous, and stains / plaques. These characteristics are related to the patterns or behavior of students who like to consume sweet foods like candy, bread, and chocolate. School Dental Health Efforts (UKGS) have also not been implemented in schools. Therefore, community service is needed to be carried out with a form of socialization prevention for early caries in order to provide knowledge of the main causes, ways of spreading, impact, efforts to prevent dental caries, and providing remineralization (dental caries prevention) containing Casein Phosphopeptid-Amorphous Calcium Phosphate (CPP-ACP) to students of grade II Muhammadiyah Primary School 03 Medan. Community service activities were carried out by five service teams from the Faculty of Dentistry, University of North Sumatra on August 27, 2019, involving as many as twenty two USU FKG students who were undergoing clinical clerkship. The socialization and provision of caries prevention materials to 111 students who were in grade II of Muhammadiyah Primary School - 03 Medan.
Disinfection Effect of 10% Ricinus Communis Oil on Candida Albicans Counts of Heat Polymerized Acrylic Resin : Pengaruh Desinfeksi Minyak Ricinus Communis 10% terhadap Jumlah Candida Albicans pada Resin Akrilik Polimerisasi Panas Putri Welda Utami; Nurdiana
Dentika: Dental Journal Vol. 24 No. 1 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i1.5615

Abstract

Dentures is used to replace tooth loss. The most used denture base material is acrylic resin. The biological properties of acrylic resins give microorganisms the ability to colonize. Certain type of microorganism often found at the dentures base is Candida albicans. Denture’s disinfection is usually used to reduce Candida albicans. One of natural source that now is being widely researched is Ricinus communis oil. The purpose of this study was to analyze disinfection effect of Ricinus communis oil 10% on Candida albicans counts on heat polymerized acrylic resin. This research is an experimental laboratory study with a post-test only design. Samples was heat polymerization acrylic resin plates measuring 10 x 10 x 1 mm were made in the Department of Prosthodontic Faculty of Dentistry, Universitas Sumatera Utara with 10 plates for each for 10% Ricinus communis oil group and 0.2% chlorhexidine gluconate group (control). The Candida albicans colonies count was carried out in the Microbiology Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara using colony counter. The data obtained was statistically count with the Kruskal-Wallis Test. The result showed the decrease in Candida albicans count with the highest value in the 10% Ricinus communis oil group is 9 x 100 CFU/ml and the highest value in the 0.2% chlorhexidine gluconate group is 0 x 100 CFU/ml. The Kruskal-Wallis test showed significant results with p value of 0.0001 (p <0.05) indicating there was a disinfection effect of 10% Ricinus communis oil and 0.2% chlorhexidine gluconate on Candida albicans count of heat polymerized acrylic resin. The study concluded that 10% Ricinus communis oil effective at decreasing Candida albicans count.
In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease Kusuma Andriana; Nurdiana; Wisnu Barlianto; I Wayan Arsana Wiayasa; Masruroh Rahayu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14321

Abstract

Background: Alzheimer’s disease (AD), is a chronic neurodegenerative disease which condition ischaracterized by a decline in memory, thinking skills, and the ability to perform basic activities of dailyliving. Study showed that postmenopausal women with AD had a lower aromatase activity (p450 aromatase)in the brain compared to menopausal women without AD. To improve cognitive function in AD patients,Nigella sativa (NS) was found to have a protective effect on memory, and cognitive function. This studytherefore, aimed to investigate in silico prediction of potential compounds of Nigella sativa as aromataseagonists and ability to cross the Blood-Brain Barrier (BBB) for treatment of Alzheimer’s Disease. Methods:The data sets used in this study were collected from databases KnapSack Kanaya, PubChem, and PASSserver Way2Drug. HitPick and Autodock Vina was performed. Additionally, the systematic analysisinvolved ADMET, LMMD, and SWISS ADME. Results and Discussions: In silico test results revealed themost promising constituents in 36 active NS compounds that may have potential to reduce the severity ofthe AD, owing to its anti-inflammatory, cytochrome p450 stimulants, free radical scavengers, antioxidants,and immunomodulators. The ability of NS to cross the BBB was proven by admetSAR LMMD with ananalysis average value of 0.91 (from the highest value of 1). Further, NS can trigger cytochrome P450aromatase activity via Quercetin 3-(6’’ ‘’-feruloylglucosyl)-(1->2)-galactosyl-(1->2)-glucoside which has abetter binding affinity value than its control (androstenedione). NS through oleic acid compounds may bindto peroxisome proliferator-activated receptor gamma (PPRAG), similar to Rosiglitazone which may affecttranscription and activation regulation of PPARG. Conclusion: To be concluded, Nigella sativa could beused as a potential medicinal plant for the treatment of Alzheimer’s disease.
Pendidikan Kesehatan Kader Tentang Pantangan dan Anjuran Makan Selama Kehamilan pada Masyarakat Pesisir Desa Karampuang Kabupaten Mamuju Ashriady Ashriady; Satriani G; Nurdiana
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 5 No 2 (2020): Desember
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-dinamika.v5i2.1494

Abstract

Kondisi Desa Karampuang sebagai daerah pesisir memungkinkan masyarakat memenuhi kebutuhan dari protein hewani; ikan, udang, kepiting, cumi dan lain-lain. Berdasarkan Informasi yang diperoleh dari kader Posyandu, masih ada anggapan sebagian dari masyarakat tidak mau mengkonsumsi jenis ikan tertentu karena adanya mitos bahwa akan mempengaruhi kondisi janin setelah lahir. Selain itu, diperoleh informasi bahwa selama kehamilan ditemukan beberapa masyarakat tidak mau mengkonsumsi obat, misalnya tablet Fe karena dianggap akan memperbesar janin dalam kandungan sehingga akan mempersulit proses persalinan. Berdasarkan hal tersebut perlu melakukan pengabdian masyarakat untuk memberikan informasi yang benar kepada masyarakat dengan memanfaatkan peran kader. Metode yang digunakan adalah community relation melalui pertemuan dengan ibu hamil dan pelatihan kader kesehatan. Pertemuan dengan ibu hamil dilakukan dengan suasana yang santai melalui metode curah pendapat (brainstorming). Dalam Pertemuan ini menunjukkan keterbukaan para ibu hamil menyampaikan informasi seputar pantangan dan anjuran makan selama kehamilan. Kegiatan pelatihan kader dilakukan selama sehari, materi yang disusun terkait dengan masalah pantangan dan anjuran makan selama kehamilan, diperoleh dari pertemuan dengan ibu hamil. Materi yang diberikan tentang faktor-faktor yang mempengaruhi kehamilan, gizi pada ibu hamil, dan persiapan persalinan. Selain itu, juga dilakukan demonstrasi dengan menggunakan food model agar dapat meningkatkan pemahaman peserta. Pemberian handout materi dapat menjadi sumber belajar yang lebih selain yang disampaikan oleh pembicara dan dapat dibaca kembali di rumah. Pengabdian masyarakat ini banyak memberikan manfaat bagi ibu hamil dan kader kesehatan. Bentuk nyatanya adalah adanya peningkatan pengetahuan kader dan dan diharapkan dapat terjadi transfer knowledge dari kader kesehatan terhadap ibu hamil dan keluarganya
Pendidikan Kesehatan tentang Infeksi Saluran Kemih (ISK) pada Ibu Hamil di Kabupaten Mamuju Ashriady; Abbas Mahmud; Nurdiana
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 7 No 1 (2022): April
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-dinamika.v7i1.3023

Abstract

Ibu hamil lebih berisiko menderita Infeksi Saluran Kemih (ISK) disebabkan salah satunya oleh pengaruh hormonal, selain itu Juga dikarenakan kondisi kehamilan yang semakin membesar. Kondisi rahim dapat menekan saluran kemih, yang membuat sering buang air kecil juga dapat meningkatkan risiko infeksi ini. Salah satu bidang yang sangat berpengaruh terhadap peningkatan pengetahuan kesehatan Ibu dan Anak adalah para kader posyandu. Kader-kader posyandu ini merupakan perpanjangan tangan pelayanan untuk kesehatan Ibu dan Anak di masyarakat. Metode pengabdian masyarakat yang dilakukan adalah memberikan materi melalui pendidikan kesehatan kader dan diskusi interaktif. Kegiatan dimulai dengan melakukan koordinasi dengan Bidan, Kepala Desa dan Kepala Dusun serta kader Posyandu. Setelah pemberian edukasi kepada kader tentang ISK pada ibu hamil, selanjutnya dilakukan pendampingan kepada kader agar dapat mengaplikasikan ilmu yang diterima kepada ibu hamil di lingkungan sekitarnya. Para kader diharapkan melakukan transfer of knowledge (transfer ilmu pengetahuan) atau bahkan melakukan transformasi (melakukan sebelum menyampaikan) dari kader kepada ibu hamil dan keluarganya terkait dengan aspek pencegahan ISK pada ibu hamil. Sebagai tind lanjut dari kegiatan ini, diharapkan pendampingan dari petugas kesehatan khususnya bidan terhadap kader yang telah diberikan edukasi sehingga proses transfer knowledge (transfer ilmu pengetahuan) dari kader kepada ibu hamil dan keluarganya dapat berjalan sebagaimana yang diharapkan.
PENGGUNAAN MODEL SENTRA IMTAQ DALAM MENGEMBANGKAN NILAI-NILAI AGAMA MORAL ANAK USIA 5-6 TAHUN Nurdiana
Jurnal Talenta : Journal of Early Childhood Education Vol. 7 No. 1 (2016): JURNAL TALENTA VOL.VII NO.1 JUNI 2016
Publisher : P3M STKIP ÁISYIYAH RIAU

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Abstract

Penelitian ini dilatar belakangi oleh pentingnya keberadaan pendidikan nilai-nilai keagamaan yang merupakan pondasi yang kokoh, dan jika hal itu telah tertanam dalam diri anak sejak dini, hal ini merupakan awal yang baik bagi pendidikan anak bangsa untuk menjalani jenjang pendidikan selanjutnya. untuk mengembangkan aspek tersebut tentunya di butuhkan strategi maupun model pembelajaran yang tepat di sekolah. Tujuan dari penelitian ini adalah untuk mengetahui gambaran tentang penggunaan model sentra imtaq dalam mengembangkan Agama moral anak usia 5-6 tahun di Tk Negeri Pembina 2 pekanbaru. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan pengumpulan data melalui observasi,wawancara,dokumentasi dan cara pengolahannya dengan Reduksi data,penyajian data,dan penarikan kesimpulan. Subjek dalam penelitian ini adalah Kepala sekolah, Guru,dan anak didik yang berada di kelas sentra imtaq berjumlah 17 orang. Berdasarkan pengolahan data diperoleh hasil sebagai kesimpulan dari penelitian yaitu: penggunaan Model sentra imtaq sudah dapat mengembangkan nilai-nilai Agama moral anak usia 5-6 tahun . Hal ini berarti bahwa penggunaan Model sentra Imtaq sangat berperan penting dalam membentuk nilai-nilai Agama moral anak.
PENGGUNAAN MODEL SENTRA IMTAQ DALAM MENGEMBANGKAN NILAI-NILAI AGAMA MORAL ANAK USIA 5-6 TAHUN Nurdiana
Jurnal Talenta : Journal of Early Childhood Education Vol. 6 No. 1 (2015): JURNAL TALENTA VOL. VI NO. 1 JUNI 2015
Publisher : P3M STKIP ÁISYIYAH RIAU

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Abstract

Penelitian ini dilatar belakangi oleh pentingnya keberadaan pendidikan nilai-nilai keagamaan yang merupakan pondasi yang kokoh, dan jika hal itu telah tertanam dalam diri anak sejak dini, hal ini merupakan awal yang baik bagi pendidikan anak bangsa untuk menjalani jenjang pendidikan selanjutnya. untuk mengembangkan aspek tersebut tentunya di butuhkan strategi maupun model pembelajaran yang tepat di sekolah. Tujuan dari penelitian ini adalah untuk mengetahui gambaran tentang penggunaan model sentra imtaq dalam mengembangkan Agama moral anak usia 5-6 tahun di Tk Negeri Pembina 2 pekanbaru. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan pengumpulan data melalui observasi,wawancara,dokumentasi dan cara pengolahannya dengan Reduksi data,penyajian data,dan penarikan kesimpulan. Subjek dalam penelitian ini adalah Kepala sekolah, Guru,dan anak didik yang berada di kelas sentra imtaq berjumlah 17 orang. Berdasarkan pengolahan data diperoleh hasil sebagai kesimpulan dari penelitian yaitu: penggunaan Model sentra imtaq sudah dapat mengembangkan nilai-nilai Agama moral anak usia 5-6 tahun . Hal ini berarti bahwa penggunaan Model sentra Imtaq sangat berperan penting dalam membentuk nilai-nilai Agama moral anak.
THE TRACING THE INTERNALIZATION OF ADAB IN ISLAMIC EDUCATION PERSPECTIVE OF SYED MUHAMMAD NAQUIB AL ATTAS Aida Hayani; Nurdiana; Ahmad Zulfikar Habibullah; Ahmad Salim
Sunan Kalijaga International Journal on Islamic Educational Research Vol 6 No 1 (2022)
Publisher : Pascasarjana Fakultas Ilmu Tarbiyah dan Keguruan UIN Sunan Kalijaga

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Abstract

Islam is veiled by the behavior of Muslims themselves). However, the Islamic world today, due to historical reasons in the last few centuries which is understandable, does indeed give a lot of negative impressions in the minds of non-Muslims, such as authoritarian and anti-democratic, anti-Western and progress, tendencies towards violence, corruption, and poverty. , and retarded. All the problems that have been described above are directly or indirectly related to the quality or product of education. Referring to the goals of Indonesian National Education; The method in this research is literature study. The results showed thatThe word Ta'dib according to Naquib Al-Attas is a term that is closer to the understanding of science. Or in other words, Ta'dib is understood as an educational term that emphasizes knowledge (science). In its conceptual structure, ta'dib includes elements, knowledge (science), teaching (ta'lim) and good parenting (tarbiyah). Therefore, it is no longer necessary to refer to the concept of education in Islam as tarbiyah, ta'lim and ta'dib all at once. Therefore, ta'dib is the most appropriate and accurate term for the term education in the Islamic sense.