Dewi, Bernadette Dian Novita
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The Comparison Of Antibacterial Effects On Cinnamomum Burmannii Water Extract With Penicillin Against Staphylococcus Aureus In Vitro Halim, Felicia; Dewi, Bernadette Dian Novita; Sutandhio, Silvia
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 1 (2020): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1112.866 KB) | DOI: 10.33508/jwmj.v2i1.2335

Abstract

Introduction: Along with the development of science, many varieties of microorganisms are resistant to antibiotics. To avoid cases of resistance grew severe, researchers developed alternative medicines as a substitute for antibiotics. One of the ingredients of herbs researched that has antibacterial activity is Cinnamon (Cinnamomum burmannii). Aim: This study aimed to compare antibacterial effects water extract of Cinnamomum burmannii with penicillin against Staphylococcus aureus Methods: This an experimental studies witd non-equivalent control group design. Research using the bacteria S. aureus are divided into two groups, the control group and experimental group. The concentration of Cinnamomum burmannii and penicillin are used that is 80- 150mg/L. Antibacterial test used dilution method and a microplate reader for reading absorbance. This research conducted in the laboratory of Microbiology, Faculty of Pharmacy Widya Mandala Catholic University Surabaya for 2 weeks. Result: Based on visual observations, Cinnamomum burmannii’s MIC is located at concentration 320- 600 mg/L while penicillin’s MIC is located at concentration 160- 300 mg/L. Based on the results of microdilution test, Cinnamomum burmannii’s MIC is located at concentration 160- 300 mg/L while penicillin’s MIC is located at concentration 640- 1200 mg/L. Conclusion: The conclusion of this research is giving Cinnamomum burmannii water extract in Staphylococcus aureus has efficacy or inhibitory that is not significantly different with penicillin.
DEMOGRAPHIC FACTORS AFFECTS THERAPEUTIC COMPLIANCE OF PATIENTS WITH CHRONIC MYELOCYTIC LEUKEMIA IN SURABAYA Puspitadewi, Selly Andriani; Muliono, Ari Christy; Dewi, Bernadette Dian Novita
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 4, No 2 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v4i2.3792

Abstract

Background: Leukemia is a hematologic malignancy that can affect all ages. In 2018, the death rate of leukemia in Indonesia reached 11,314 people. Imatinib is the first-line treatment for chronic myelocytic leukemia, which works by inhibiting the tyrosine kinase in the oncoprotein BCR-ABL. In Indonesia, the drug is the preferred therapy provided in hospitals and covered by the Social Security Administrator (BPJS). The side effects of these drugs are different from person to person, such as nausea, vomiting, headaches, indigestion, and joint pain. Compliance with taking medication is a determinant in the success of therapy, but several factors that influence compliance include age, gender, education level, and total income each monthPurpose: To compare the demographic factors that affect patients with chronic myelocytic leukemia in taking drugs in the Gist and Leukemia Community Surabaya.Method: This study used a Cross-Sectional Analytic research design. This research was conducted in September-November 2020 at the Gist and Leukemia Community Surabaya. The Gist and Leukemia Community in Surabaya is a community formed for sufferers of Chronic Myelocytic Leukemia and Gist (Tumors in the Stomach). The sample size required in the study, according to the Slovin formula, is 67 respondents. The sampling technique in this study is non-probability sampling so that this figure is met. Retrieval of patient demographic data and filling out the MMAS-8 questionnaire was done by filling in the form provided by the researcher in the form of a link on the google form. After that, short structured interviews were conducted with several respondents by telephone.Result: Based on the research that has been conducted, the results obtained are 67 respondents with high levels of compliance as many as 28 respondents, 22 respondents with moderate compliance, and 17 respondents with low compliance. With the number of male sex more than female, namely 40 men and 27 women. In addition, 20 respondents were aged 50-60 years, 22 respondents were aged 40-49 years old, 17 respondents were aged 30-39 years old, and eight respondents were aged 20-29 years old. In this study, the results obtained were 28 respondents with education levels of D3 / S1 / S2 / S3, 25 respondents with education levels of high school students, and 14 respondents with education levels of junior high school students. Also obtained the results of respondents with a monthly income of less than Rp 4,200,000 more, namely as many as 44 people compared to respondents with a monthly income, more than Rp 4,200,000 as many as 23 people. After obtaining the research data, the results of hypothesis testing using the Chi-Square test with sig. p <0.05. Results sig. p <0.05 means that the variable affects medication compliance in the respondent during sig. p> 0.05 means that the variable does not affect medication compliance among respondents. The results show that the factor influencing medication compliance in patients with chronic myelocytic leukemia is the monthly income with a sig. 0.025. Meanwhile, other factors such as gender, age, and education level do not affect medication compliance in patients with chronic myelocytic leukemia with sig. > 0.05.Conclusion: In the research that has been conducted with a total of 67 respondents, it can be concluded that Chronic Myelocytic Leukemia patients who are members of the Surabaya Gist and Leukemia Community for the period September-November 2020 are still in the category of obedience in consuming Imatinib drugs. The demographic factor that affects respondents' compliance with medication is the amount of income per month.