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All Journal Biomedical Journal of Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Permana, Adhi
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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CORRELATION OF SERUM SCLEROSTIN LEVELS WITH CAROTID INTIMA MEDIA THICKNESS IN CHRONIC KIDNEY DISEASE HEMODIALYSIS Permana, Adhi; Effendi, Ian; Indrajaya, Taufik
Biomedical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10185

Abstract

Chronic kidney disease is associated with a high mortality rate, especially cardiovascular disease associated with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing the occurrence of vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The aim of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing hemodialysis. In this cross section, the concentration of sclerostin was measured by examination of enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are declared high if above 162 pg / ml there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis duration is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.
Rasionalitas Penggunaan Kortikosteroid pada Terapi Asma Bronkial di Poliklinik Penyakit Dalam Rumah Sakit Muhammadiyah Palembang Fitriani, Nyayu; Permana, Adhi; Diningrum, Aryani
Syifa'Medika Vol 9, No 1 (2018): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v9i1.1340

Abstract

Asma merupakan penyakit yang tidak khas, biasanya merupakan peradangan saluran napas kronis yang ditandai oleh riwayat gejala gangguan pernapasan seperti mengi, sesak napas, dan batuk yang bervariasi intensitasnya dari waktu ke waktu, bersamaan dengan keterbatasan aliran udara saat ekspirasi. Kortikosteroid sebagai pengontrol adalah medikasi asma jangka panjang untuk mengontrol asma. Tujuan penelitian, mengidentifikasi rasionalitas kortikosteroid pada terapi asma di Rumah Sakit Muhammadiyah Palembang. Desain penelitian deskriptif dengansampel penelitian seluruh pasien asma yang berobat di Bagian Poliklinik Penyakit Dalam Rumah Sakit Muhammadiyah Palembang periode Oktober - November 2016 dengan jumlah 39 pasien. Hasil penelitian didapatkan 3 jenis kortikosteroid yangdigunakan, yaitu budesonide 74,4%; flutikason 23%; dan methylprednisolone 2,6%. Penggunaan kortikosteroid yang tepat dosis pada pasien terkontrol baik 17,9%; dan tidak terkontrol 66,7%. Tepat cara pemberian pada pasien terkontrol baik 20,5%; dan tidak terkontrol 76,9%. Tepat waktu pemberian pada pasien terkontrol baik 20,5%; dan tidak terkontrol 79,5%. Simpulan, sebanyak 82% penggunaan kortikosteroid pada terapi asma di Rumah Sakit Muhammadiyah Palembang periode Oktober-November 2016 masih rasional.
Co-Authors Diningrum, Aryani Effendi, Ian Fitriani, Nyayu Indrajaya, Taufik