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Sumadiono
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Mycophenolate Mofetil for a Flare Child Lupus Nephritis: A Case Reports Puspita, Gina; Desy Rusmawatiningtyas; Sumadiono
Archives of The Medicine and Case Reports Vol. 2 No. 1 (2021): Archives of The Medicine and Case Reports
Publisher : Hanif Medisiana Publisher - Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v2i1.21

Abstract

Renal involvement is the most common complication of systemic lupus erythematosus (SLE) and is also an important predictor of patient mortality. The incidence of flares is estimated at 65% each year in patients with lupus nephritis. Therapy in lupus nephritis with flare also uses high doses of steroid agents and strong immunosuppression agent. Mycophenolate mofetil (MMF) as a immunosuppression agent tends to favor for flare in lupus nephritis. We describe a patient who had flare in lupus nephritis that resolved with high-dose steroid and MMF. The combination of immunosuppression agent and high-dose corticosteroid is an effective for control of active diseases. Cyclophosphamide as the steroid sparing agent was discontinued because of adverse effect as well as hematuria. Partial remission was later achieved and maintained with MMF and corticosteroid after five month with protocol treatment. Thus, MMF while maintaining the steroid dose may induce remission for this case.
Co-Authors Desy Rusmawatiningtyas Puspita, Gina