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All Journal Jurnal Farmasi Udayana JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Katalisator Jurnal Teladan: Jurnal Ilmu Pendidikan dan Pembelajaran Jurnal Farmasi Higea Academy of Education Journal Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Pengabdian Harapan Ibu (JPHI)
Deny Sutrisno
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Ilmiah Universitas Batanghari Jambi

 1 
Analisis Interaksi Obat Secara Farmakokinetik dan Farmakodinamik Terhadap Pasien Nefropati Diabetik di Rumah Sakit X Kota Jambi Tahun 2022 Zahratul Farah; Deny Sutrisno; Aisa Dinda Mitra
Jurnal Ilmiah Universitas Batanghari Jambi Vol 24, No 1 (2024): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v24i1.4688

Abstract

Diabetic nephropathy (ND) is a complication of diabetes in the kidney. Nephropathy, or kidney disease, is the leading cause of death and disability in diabetes. The first clinical manifestation of diabetic nephropathy is microalbuminuria. If a patient is diagnosed with microalbuminuria, the development of end-stage renal and cardiovascular disease can be prevented by controlling blood pressure, glucose, and lipids. This study aimed to determine pharmacokinetic and pharmacodynamic drug interactions, determine drug interactions and severity in patients, determine the relationship between age and drug severity and gender relationship with drug severity in patients with diabetic nephropathy at X Hospital Jambi City in 2022. The method used in this research is descriptive method. The data collected in this study came from the medical records of diabetic nephropathy patients at X Hospital Jambi City in 2022. The total population in this study was 67 patients with a total sample of 46 patients. The results showed that the highest prevalence in the sample was female (56.52%), elderly patients aged 46-55 years (47.83%), drugs that interact with lantus ˃˂ novorapid (8.43%), patients experiencing drug interactions (71.74%), pharmacodynamic interactions (92.77%), pharmacokinetic interactions (4.82%), minor (10.84%), moderate (78.31%), and major severity (10.84%). The conclusions drawn from this study were based on the interaction mechanism, namely there were 6 cases (7.23%) of pharmacokinetic interactions and 77 cases of pharmacodynamic interactions (92.77%). Based on interactions with 9 cases of minor severity (10.84%), 65 cases of moderate severity (78.31%), and 9 cases of major severity (10.84%). And there is no relationship between the severity of the drug and age and gender.
Co-Authors Aisa Dinda Mitra Barmi Hartesi Chelisia Putri Badri Deti Florentina Fitri Diana Hairani Hairani Halimatusaa'diyah Halimatussa'diyah Halimatussa'diyah Kharis Marshanda Marshanda Lia Anggresani Marni Septya Damanik Muammar Khadafi Rahmadevi Rasmala Dewi Santi Perawat Wiwit Wulan Safitri Yulianis . Zahratul Farah